Data Availability
All available data was included directly within the manuscript or within supplementary tables available online at the time of publication.
References
Kernan KF, Ghaloul-Gonzalez L, Vockley J, Lamb J, Hollingshead D, Chandran U, et al. Prevalence of pathogenic and potentially pathogenic inborn error of immunity associated variants in children with severe sepsis. J Clin Immunol. 2022;42(2):350–64.
Chinn IK, Orange JS. A 2020 update on the use of genetic testing for patients with primary immunodeficiency. Expert Rev Clin Immunol. 2020;16(9):897–909.
Boussaroque A, Bergougnoux A, Raynal C, Audrézet MP, Sasorith S, Férec C, Bienvenu T, Girodon E. Pitfalls in the interpretation of CFTR variants in the context of incidental findings. Hum Mutat. 2019;40(12):2239–46. https://doi.org/10.1002/humu.23884.
Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17(5):405–24.
Zhang D, Zhao L, Li B, He Z, Wang GT, Liu DJ, et al. SEQSpark: a complete analysis tool for large-scale rare variant association studies using whole-genome and exome sequence data. Am J Hum Genet. 2017;101(1):115–22.
Author information
Authors and Affiliations
Contributions
All authors contributed in a substantive and intellectual manner to the manuscript.
Corresponding author
Ethics declarations
Ethical Approval
Not applicable.
Consent to Participate
Not applicable.
Consent for Publication
All authors have consented to the publication of this manuscript.
Competing Interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Prince, B.T., Varga, E.A. & McBride, K.L. Germline Variant Interpretation in Children with Severe Sepsis. J Clin Immunol 43, 312–314 (2023). https://doi.org/10.1007/s10875-022-01388-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10875-022-01388-1