Skip to main content

Advertisement

Springer Nature Link
Log in

Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice

  • Key Review Article
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

Abstract

During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that although the basic roadmap of blood development is generally conserved across mammals, evolutionary pressures have generated many differences between the species that have important biological and translational implications. To enhance the utility of the mouse as a model organism, it is more important than ever that research data are presented with regard to how they might be influenced by the species of origin as well as the developmental source of the hematopoietic tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Silver LM. Mouse genetics, Concepts and Applications. New York: Oxford University Press; 1995.

    Google Scholar 

  2. Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963;197:452–4.

    Article  PubMed  CAS  Google Scholar 

  3. Case SS, et al. Stable transduction of quiescent CD34(+)CD38(−) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A. 1999;96:2988–93.

    Article  PubMed  CAS  Google Scholar 

  4. Ishikawa F, et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor gamma chain(null) mice. Blood. 2005;106:1565–73.

    Article  PubMed  CAS  Google Scholar 

  5. Kiel MJ, Yilmaz OH, Iwashita T, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121:1109–21.

    Article  PubMed  CAS  Google Scholar 

  6. Sintes J, Romero X, Marin P, Terhorst C, Engel P. Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells. Exp Hematol. 2008;36:1199–204.

    Article  PubMed  CAS  Google Scholar 

  7. Doulatov S, Notta F, Laurenti E, Dick JE. Hematopoiesis: a human perspective. Cell Stem Cell. 2012;10:120–36.

    Google Scholar 

  8. Sitnicka E, et al. Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells. Blood. 2003;102:881–6.

    Article  PubMed  CAS  Google Scholar 

  9. Kohn LA, Hao Q-L, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HKA, Crooks GM. Lymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin, Nat Immunol. 2012;13(10):963–71

    Google Scholar 

  10. Randall TD, Lund FE, Howard MC, Weissman IL. Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood. 1996;87:4057–67.

    PubMed  CAS  Google Scholar 

  11. Weksberg DC, Chambers SM, Boles NC, Goodell MA. CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood. 2008;111:2444–51.

    Article  PubMed  CAS  Google Scholar 

  12. Sitnicka E, et al. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity. 2002;17:463–72.

    Article  PubMed  CAS  Google Scholar 

  13. Adolfsson J, et al. Upregulation of Flt3 expression within the bone marrow Lin(−)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001;15:659–69.

    Article  PubMed  CAS  Google Scholar 

  14. Mohrin M, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010;7:174–85.

    Google Scholar 

  15. Trobridge GD, Kiem HP. Large animal models of hematopoietic stem cell gene therapy. Gene Ther. 2010;17:939–48.

    Google Scholar 

  16. Rodriguez RM, Lopez-Vazquez A, Lopez-Larrea C. Immune systems evolution. Adv Exp Med Biol. 2012;739:237–51.

    Google Scholar 

  17. Crozat K, et al. Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets. Immunol Rev. 2010;234:177–98.

    Google Scholar 

  18. Block MS, Nevala WK, Leontovich AA, Markovic SN. Differential response of human and mouse dendritic cells to VEGF determines interspecies discrepancies in tumor-mediated TH1/TH2 polarity shift. Clin Cancer Res. 2011;17:1776–83.

    Google Scholar 

  19. Koo GC, Peppard JR. Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma. 1984;3:301–3.

    Article  PubMed  CAS  Google Scholar 

  20. Inngjerdingen M, Kveberg L, Naper C, Vaage JT. Natural killer cell subsets in man and rodents. Tissue Antigens. 2011;78:81–8.

    Google Scholar 

  21. Wu H, et al. Expression patterns and functions of toll-like receptors in mouse sertoli cells. Endocrinology. 2008;149:4402–12.

    Article  PubMed  CAS  Google Scholar 

  22. Roach JC, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A. 2005;102:9577–82.

    Article  PubMed  CAS  Google Scholar 

  23. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17:1–14.

    Article  PubMed  CAS  Google Scholar 

  24. Rehli M. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol. 2002;23:375–8.

    Article  PubMed  CAS  Google Scholar 

  25. Sarvestani ST, Williams BR, Gantier MP. Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing. J Interferon Cytokine Res. 2012;32:350–61.

    Google Scholar 

  26. Schroder K, et al. Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A. 2011;109:E944-53.

    Google Scholar 

  27. Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol. 2004;172:2731–8.

    PubMed  CAS  Google Scholar 

  28. Wun KS, et al. Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex. J Biol Chem. 2012;287:39139–48.

    Google Scholar 

  29. Rothenberg EV, Moore JE, Yui MA. Launching the T-cell-lineage developmental programme. Nat Rev Immunol. 2008;8:9–21.

    Article  PubMed  CAS  Google Scholar 

  30. Plum J, et al. Human intrathymic development: a selective approach. Semin Immunopathol. 2008;30:411–23.

    Article  PubMed  CAS  Google Scholar 

  31. Hao QL, et al. Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Blood. 2008;111:1318–26.

    Article  PubMed  CAS  Google Scholar 

  32. Blom B, et al. TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation. Blood. 1999;93:3033–43.

    PubMed  CAS  Google Scholar 

  33. Bottardi S, Aumont A, Grosveld F, Milot E. Developmental stage-specific epigenetic control of human beta-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation. Blood. 2003;102:3989–97.

    Article  PubMed  CAS  Google Scholar 

  34. Ramkissoon SH, et al. Hematopoietic-specific microRNA expression in human cells. Leuk Res. 2006;30:643–7.

    Article  PubMed  CAS  Google Scholar 

  35. Waterston RH, et al. Initial sequencing and comparative analysis of the mouse genome. Nature. 2002;420:520–62.

    Article  PubMed  CAS  Google Scholar 

  36. de Haan G, Nijhof W, Van Zant G. Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity. Blood. 1997;89:1543–50.

    PubMed  Google Scholar 

  37. Spangrude GJ, Brooks DM. Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood. 1993;82:3327–32.

    PubMed  CAS  Google Scholar 

  38. Schroeder MA, DiPersio JF. Mouse models of graft-versus-host disease: advances and limitations. Dis Model Mech. 2011;4:318–33.

    Google Scholar 

Download references

Acknowledgments

CP is a St. Baldrick’s Foundation Scholar and is the recipient of a St. Baldrick’s scholar award, and a CHLA K12 Child Health Research Career Development Award. This work was also supported by National Institutes of Health (P01 HL073104 and 1P01AI072686) and the California Institute of Regenerative Medicine (RM1-01707) to G.M.C.

Author information

Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Chintan Parekh

  2. Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Chintan Parekh

  3. Department of Pathology & Laboratory Medicine, Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA

    Gay M. Crooks

  4. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA

    Gay M. Crooks

  5. Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA

    Gay M. Crooks

Authors
  1. Chintan Parekh
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Gay M. Crooks
    View author publications

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Gay M. Crooks.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parekh, C., Crooks, G.M. Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice. J Clin Immunol 33, 711–715 (2013). https://doi.org/10.1007/s10875-012-9844-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10875-012-9844-3

Keywords