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HLA Class II (DRB, DQA1 and DQB1) Allele and Haplotype Frequencies in the Patients with Pemphigus Vulgaris

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Abstract

Introduction

Pemphigus vulgaris (PV), an autoimmune disease affecting the skin and mucous membranes, is associated with some human leukocyte antigen (HLA) class II alleles and haplotypes.

Materials and Methods

In order to evaluate the association of HLA-DR and DQ alleles and haplotypes in Iranian non-Jewish patients with PV, 52 patients with PV and 180 normal subjects as control group were investigated in this study.

Results and Discussion

HLA-DRB1*04, -DRB1*1401, -DRB4, -DQA1*0104, -DQA1*03011, -DQB1*0302, and -DQB1*0502 alleles have been significantly increased in our patients group. Moreover, the haplotypes HLA-DRB1*04/-DQA1*03011/-DQB1*0302 and HLA-DRB1*1401/-DQA1*0104/-DQB1*0502 increased significantly in our patients. In contrast, the following alleles decreased significantly in our patients: HLA-DRB1*15, -DRB1*0301, -DRB1*07, -DRB1*11, -DRB5, -DQA1*0101, -DQA1*0103, -DQA1*201, -DQA1*05, -DQB1*0201, -DQB1*0301, -DQB1*06011, and -DQB1*0602. In addition, HLA-DRB1*15/-DQA1*0103/-DQB1*06011, HLA-DRB1*0301/-DQA1*05011/-DQB1*0201, HLA-DRB1*07/-DQA1*0201/-DQB1*0201, and HLA-DRB1*11/-DQA1*05/-DQB1*03011 decreased significantly in our patients. Genetic factors are involved in the occurrence of PV; HLA-DRB1*04 and -DRB1*1401 alleles and the related haplotypes are suggestive to be two major PV susceptibility factors in our population study.

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Authors and Affiliations

  1. Department of Dermatology, Razi Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Sheida Shams & Maryam Yousefi

  2. Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Ali Akbar Amirzargar, Ghasem Solgi, Farideh Khosravi, Bita Ansaripour, Batoul Moradi & Behrouz Nikbin

  3. Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Ali Akbar Amirzargar & Behrouz Nikbin

  4. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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  1. Sheida Shams
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  2. Ali Akbar Amirzargar
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Correspondence to Ali Akbar Amirzargar.

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Shams, S., Amirzargar, A.A., Yousefi, M. et al. HLA Class II (DRB, DQA1 and DQB1) Allele and Haplotype Frequencies in the Patients with Pemphigus Vulgaris. J Clin Immunol 29, 175–179 (2009). https://doi.org/10.1007/s10875-008-9244-x

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  • DOI: https://doi.org/10.1007/s10875-008-9244-x

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