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Decreased Frequency and Function of Circulating Plasmocytoid Dendritic Cells (pDC) in Hepatitis B Virus Infected Humans

  • Published: November 2004
  • Volume 24, pages 637–646, (2004)
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Journal of Clinical Immunology Aims and scope Submit manuscript
Decreased Frequency and Function of Circulating Plasmocytoid Dendritic Cells (pDC) in Hepatitis B Virus Infected Humans
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  • XUE-ZHANG DUAN1,2,
  • MIN WANG1,
  • HAN-WEI LI1,
  • HUI ZHUANG2,
  • DONGPING XU1 &
  • …
  • FU-SHENG WANG1 

  • 507 Accesses

  • Explore all metrics

Abstract

The Type 2 precusor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity. To understand the function of pDC during hepatitis B virus infection, the frequency and function of circulating pDC were analyzed by flow cytometric analysis, and IFN-α secretion of total PBMCs was determined by ELISA assay in 25 healthy subjects and 116 patients at various stages of chronic hepatitis B virus infection (CHB). The number of circulating pDC was found to be significantly lower in patients with CHB and associated liver cirrhosis (LC). The ability of PBMCs to secrete IFN-α also decreased significantly. There was a corresponding decrease of circulating NK cells and CD8+ T cells. We observed that lamuvidine antiviral therapy restored the number of circulating pDC and there was a reversal of pDC frequency with the control of HBV replication in chronic HBV patients, indicating these subjects are unlikely to be totally immunecompromised. The decrease of pDC was found to be related to nosocomial infections in LC patients. Our results suggest that CHB patients probably have a quantitative and qualitative impairment of circulating pDC or NK cells, which may be associated with HBV persistent infection as well as the nosocomial infections that arise in LC patients.

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Author information

Authors and Affiliations

  1. Research Centre of Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, People’s Republic of China

    XUE-ZHANG DUAN, MIN WANG, HAN-WEI LI, DONGPING XU & FU-SHENG WANG

  2. Department of Microbiology, Peking University Health Science Center, Beijing, People’s Republic of China

    XUE-ZHANG DUAN & HUI ZHUANG

Authors
  1. XUE-ZHANG DUAN
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  2. MIN WANG
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  3. HAN-WEI LI
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  4. HUI ZHUANG
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  5. DONGPING XU
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  6. FU-SHENG WANG
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Corresponding authors

Correspondence to HUI ZHUANG or FU-SHENG WANG.

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DUAN, XZ., WANG, M., LI, HW. et al. Decreased Frequency and Function of Circulating Plasmocytoid Dendritic Cells (pDC) in Hepatitis B Virus Infected Humans. J Clin Immunol 24, 637–646 (2004). https://doi.org/10.1007/s10875-004-6249-y

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  • Issue Date: November 2004

  • DOI: https://doi.org/10.1007/s10875-004-6249-y

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  • chronic hepatitis
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  • liver cirrhosis
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