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Synthesis and X-ray Crystallographic Analysis of Pharmaceutical Model Rac-Ibuprofen Cocrystal

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Abstract

The hydrogen bonded cocrystals of rac-ibuprofen with cocrystal former 2-aminopyrimidine was synthesized and characterized in term of crystal engineering and supramolecular chemistry. Pharmaceutical cocrystal (PCC) of rac-ibuprofen was prepared by solvent-free grinding and suitable crystals grown from solution and characterized by single crystal X-ray crystallography. The structure adopted both supramolecular heterosynthons and homosynthons in addition to some other non–covalent motifs.

Graphical Abstract

The hydrogen bonded cocrystals of rac-ibuprofen with cocrystal former 2-aminopyrimidine 1 was synthesized and characterized in term of crystal engineering and supramolecular chemistry. Pharmaceutical cocrystal (PCC) of rac-ibuprofen was prepared by solvent-free grinding and suitable crystals grown from solution and characterized by single crystal X-ray crystallography. The structure adopted both supramolecular heterosynthons and homosynthons in addition to some other non-covalent motifs

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Acknowledgments

The author thanks Mutah University for support needed to finish this work. Special thanks to Prof. Koh Lip Lin and Ms. Geok Kheng Tan (the National University of Singapore) for running the X-ray experiment. Finally, great thanks to Prof. Mike Zaworotko (University of South Florida) for his great support and valuable comments.

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Authors and Affiliations

  1. Department of Chemistry, Mutah University, P.O. Box 7, Mutah 61710, Al Karak, Jordan

    Solhe F. Alshahateet

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  1. Solhe F. Alshahateet
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Correspondence to Solhe F. Alshahateet.

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Alshahateet, S.F. Synthesis and X-ray Crystallographic Analysis of Pharmaceutical Model Rac-Ibuprofen Cocrystal. J Chem Crystallogr 41, 276–279 (2011). https://doi.org/10.1007/s10870-010-9872-x

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  • DOI: https://doi.org/10.1007/s10870-010-9872-x

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