Abstract
Converging data from epidemiological, ecological, and clinical studies have shown that selenium (Se) can decrease the risk for some types of human cancers. Induction of apoptosis is considered an important cellular event that can account for the cancer preventive effects of Se. Prior to occurrence of apoptosis, Se compounds alter the expression and/or activities of signaling molecules, mitochondria-associated factors, transcriptional factors, tumor suppressor genes, and cellular reduced glutathione. Mechanistic studies have demonstrated that the methylselenol metabolite pool has many desirable attributes of chemoprevention, whereas the hydrogen selenide pool with excess of selenoprotein synthesis can lead to DNA single-strand breaks. To elucidate the effects of Se on cytotoxic events, it should be remembered that the chemical forms and the dose of Se, and the experimental system used, are determinants of its biological activities. This mini-review focuses on elucidation of the molecular mechanisms of cancer prevention by Se with the apoptotic approach.
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References
Allan CB, Lacourciere GM, Stadtman TC (1999) Annu Rev Nutr 19:1–16
Behrend L, Henderson G, Zwacka RM (2003) Biochem Soc Trans 31:1441–1444
Benhar M, Engelberg D, Levitzki A (2002) EMBO Rep 3:420–425
Brown KM, Pickard K, Nicol F, Beckett GJ, Duthie GG, Arthur JR (2000) Clin Sci 98:593–599
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Science 282:1318–1321
Combs GF, Jr, Gray WP (1998) Pharmacol Ther 79:179–192
Coppola S, Ghibelli L (2000) Biochem Soc Trans 28:56–61
Costantini P, Belzacq AS, Vieira HL, Larochette N, de Pablo MA, Zamzami N, Susin SA, Brenner C, Kroemer G (2000) Oncogene 19:307–314
Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C (2003) Can Res 63:52–59
Drake EN (2006) Med Hypotheses 67:318–322
El-Bayoumy K (2001) Mutat Res 475:123–139
Fleming J, Ghose A, Harrison PR (2001) Nutr Can 40:42–49
Ganther HE (1999) Carcinogenesis 20:1657–1666
Hu H, Jiang C, Ip C, Rustum YM, Lu J (2005a) Clin Can Res 11:2379–2388
Hu H, Jiang C, Li G, Lu J (2005b) Carcinogenesis 26:1374–1381
Hu H, Jiang C, Schuster T, Li GX, Daniel PT, Lu J (2006) Mol Can Ther 5:1873–1882
Jackson AL, Loeb LA (2001) Mutat Res 477:7–21
Jiang C, Wang Z, Ganther H, Lu J (2001) Can Res 61:3062–3070
Jiang C, Hu H, Malewicz B, Wang Z, Lu J (2004) Mol Can Ther 3:877–884
Jimbo A, Fujita E, Kouroku Y, Ohnishi J, Inohara N, Kuida K, Sakamaki K, Yonehara S, Momoi T (2003) Exp Cell Res 283:156–166
Karunasinghe N, Ryan J, Tuckey J, Masters J, Jamieson M, Clarke LC, Marshall JR, Ferguson LR (2004) Can Epidemiol Biomarkers Prev 13:391–397
Karp DD (2005) Clin Adv Hematol Oncol 3:313–315
Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali I, Viner JL, Sigman CC (2000) J Nutr 130:467S–471S
Kim TS, Yun BY, Kim IY (2003) Biochem Pharmacol 66:2301–2311
Klein EA, Thompson IM, Lippman SM, Goodman PJ, Albanes D, Taylor PR, Coltman C (2000) Prostate Can Prostatic Dis 3:145–151
Klein EA (2004) Ann NY Acad Sci 1031:234–241
Kowalska E, Narod SA, Huzarski T, Zajaczek S, Huzarska J, Gorski B, Lubinski J (2005) Can Epidemiol Biomarkers Prev 14:1302–1306
Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN (2005) J Biol Chem 280:37839–37845
Li H, Kantoff PW, Giovannucci E, Leitzmann MF, Gaziano JM, Stampfer MJ, Ma J (2005) Can Res 65:2498–2504
Mantovani G, Maccio A, Madeddu C, Mura L, Gramignano G, Lusso MR, Mulas C, Mudu MC, Murgia V, Camboni P, Massa E, Ferreli L, Contu P, Rinaldi A, Sanjust E, Atzei D, Elsener B (2002) Int J Can 98:84–91
Mark SD, Qiao YL, Dawsey SM, Wu YP, Katki H, Gunter EW, Fraumeni JF, Jr, Blot WJ, Dong ZW, Taylor PR (2000) J Natl Can Inst 92:1753–1763
Meuillet E, Stratton S, Prasad CD, Goulet AC, Kagey J, Porterfield B, Nelson MA (2004) J Cell Biochem 91:443–458
Rayman MP (2000) Lancet 356:233–241
Saito Y, Yoshida Y, Akazawa T, Takahashi K, Niki E (2003) J Biol Chem 278:39428–39434
Shen H, Yang C, Liu J, Ong C (2000) Free Radic Biol Med 28:1115–1124
Shen HM, Yang CF, Ding WX, Liu J, Ong CN (2001) Free Radic Biol Med 30:9–21
Shen HM, Ding WX, Ong CN (2002) Free Radic Biol Med 33:552–561
Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y (1996) Biochem Biophy Res Commun 226:561–565
Spallholz JE, Palace VP, Reid TW (2004) Biochem Pharmacol 67:547–554
Spyrou G, Bjornstedt M, Skog S, Holmgren A (1996) Can Res 56:4407–4412
Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, Lambeth JD (1999) Nature 401:79–82
Takahashi M, Sato T, Shinohara F, Echigo S, Rikiishi H (2005) Int J Oncol 27:489–495
Tapiero H, Townsend DM, Tew KD (2003) Biomed Pharmacother 57:134–144
Terada A, Yoshida M, Seko Y, Kobayashi T, Yoshida K, Nakada M, Nakada K, Echizen H, Ogata H, Rikihisa T (1999) Nutrition 15:651–655
Wang X (2001) Genes Dev 15:2922–2933
Waters DJ, Shen S, Glickman LT, Cooley DM, Bostwick DG, Qian J, Combs GF, Jr, Morris JS (2005) Carcinogenesis 26:1256–1262
Wojtczak L, Wieckowski MR, Schonfeld P (1998) Arch Biochem Biophys 357:76–84
Yamaguchi K, Uzzo RG, Pimkina J, Makhov P, Golovine K, Crispen P, Kolenko VM (2005) Oncogene 24:5868–5877
Zhao R, Xiang N, Domann FE, Zhong W (2006) Can Res 66:2296–2304
Zhou N, Xiao H, Li TK, Nur EKA, Liu LF (2003) J Biol Chem 278:29532–29537
Zu K, Ip C (2003) Can Res 63:6988–6995
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Rikiishi, H. Apoptotic cellular events for selenium compounds involved in cancer prevention. J Bioenerg Biomembr 39, 91–98 (2007). https://doi.org/10.1007/s10863-006-9065-7
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DOI: https://doi.org/10.1007/s10863-006-9065-7