Abbreviations
- SH3:
-
Src-homology 3 domain
- SH2:
-
Src-homology 2 domain
- NMR:
-
Nuclear magnetic resonance
- NOE:
-
Nuclear overhauser effect
- NOESY:
-
Nuclear overhauser enhancement spectroscopy
- TOCSY:
-
Total correlation spectroscopy
- Itk:
-
Interleukin-2 tyrosine kinase
- Btk:
-
Bruton’s tyrosine kinase
- RDC:
-
Residual dipolar coupling
References
Agrawal V, Kishan KV (2002) Promiscuous binding nature of SH3 domains to their target proteins. Protein Pept Lett 9:185–193
Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL (1997) Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 385:93–97
Berg LJ (2007) Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol 7:479–485
Berjanskii MV, Neal S, Wishart DS (2006) PREDITOR: a web server for predicting protein torsion angle restraints. Nucleic Acids Res 34:W63–W69
Boggon TJ, Eck MJ (2004) Structure and regulation of Src family kinases. Oncogene 23:7918–7927
Brazin KN, Fulton DB, Andreotti AH (2000) A specific intermolecular association between the regulatory domains of a Tec family kinase. J Mol Biol 302:607–623
Breheny PJ, Laederach A, Fulton DB, Andreotti AH (2003) Ligand specificity modulated by prolyl imide bond cis/trans isomerization in the Itk SH2 domain: a quantitative NMR study. J Am Chem Soc 125:15706–15707
Cavanagh J Fairbrother WJ, Palmer AG, Rance M, Skelton NJ (2007) Protein NMR principles and practice. Elsevier, Burlington
Cordier F, Barfield M, Grzesiek S (2003) Direct observation of Calpha-Halpha.O=C hydrogen bonds in proteins by interresidue h3JCalphaC’ scalar couplings. J Am Chem Soc 125:15750–15751
DeLano WL (2002) The PyMOL molecular graphics system. DeLano Scientific, San Carlos
Hansen MR, Mueller L, Pardi A (1998) Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions. Nat Struct Biol 5:1065–1074
Hansson H, Mattsson PT, Allard P, Haapaniemi P, Vihinen M, Smith CI, Hard T (1998) Solution structure of the SH3 domain from Bruton’s tyrosine kinase. Biochemistry 37:2912–2924
Hooft RW, Vriend G, Sander C, Abola EE (1996) Errors in protein structures. Nature 381:272
Keller R (2005) Optimizing the process of nuclear magnetic resonance spectrum analysis and computer aided resonance assignment. Biology. Diss. ETH Zurich NO. 15947, Zurich
Laederach A, Cradic KW, Fulton DB, Andreotti AH (2003) Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk. J Mol Biol 329:1011–1020
Laskowski RA, Rullmannn JA, MacArthur MW, Kaptein R, Thornton JM (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8:477–486
McCoy MA, Wyss DF (2002) Structures of protein-protein complexes are docked using only NMR restraints from residual dipolar coupling and chemical shift perturbations. J Am Chem Soc 124:2104–2105
Schwartzberg PL, Finkelstein LD, Readinger JA (2005) TEC-family kinases: regulators of T-helper-cell differentiation. Nat Rev Immunol 5:284–295
Schwieters CD, Kuszewski JJ, Tjandra N, Clore GM (2003) The Xplor-NIH NMR molecular structure determination package. J Magn Reson 160:65–73
Zweckstetter M, Bax A (2001) Characterization of molecular alignment in aqueous suspensions of Pf1 bacteriophage. J Biomol NMR 20:365–377
Acknowledgments
This work is supported by grants from the National Institutes of Health (NIAID, AI43957) and a Roy J. Carver Charitable Trust graduate fellowship to A.S.
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Severin, A., Fulton, D.B. & Andreotti, A.H. Murine Itk SH3 domain. J Biomol NMR 40, 285–290 (2008). https://doi.org/10.1007/s10858-008-9231-9
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DOI: https://doi.org/10.1007/s10858-008-9231-9