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Mesoporous silica nanoparticles in nanomedicine applications

  • Special Issue: ESB 2017
  • Review Article
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Abstract

In the last few years mesoporous silica nanoparticles (MSNs) have gained the attention of the nanomedicine research community, especially for the potential treatment of cancer. Although this topic has been reviewed before, periodic updates on such a hot topic are necessary due to the dynamic character of this field. The reasons that make MSNs so attractive for designing controlled drug delivery systems lie beneath their physico-chemical stability, easy functionalisation, low toxicity and their great loading capacity of many different types of therapeutic agents. The present brief overview tries to cover some of the recent findings on stimuli-responsive mesoporous silica nanocarriers together with the efforts to design targeted nanosystems using that platform. The versatility of those smart nanocarriers has promoted them as very promising candidates to be used in the clinic in the near future to overcome some of the pitfalls of conventional medicine.

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Acknowledgements

This work was supported by the European Research Council, ERC-2015-AdG (VERDI), Proposal no. 694160 and Ministerio de Economía y Competitividad (MINECO) (MAT2015-64831-R grant).

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  1. Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, Madrid, 28040, Spain

    Miguel Manzano & María Vallet-Regí

  2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

    Miguel Manzano & María Vallet-Regí

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  1. Miguel Manzano
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Correspondence to María Vallet-Regí.

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Manzano, M., Vallet-Regí, M. Mesoporous silica nanoparticles in nanomedicine applications. J Mater Sci: Mater Med 29, 65 (2018). https://doi.org/10.1007/s10856-018-6069-x

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