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Experimental maxillary sinus augmentation using a highly bioactive glass ceramic

  • Clinical Applications of Biomaterials
  • Original Research
  • Published:
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Abstract

Physicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO—particulate bovine HA Bio-Oss® (BO), BO+G—particulate bovine HA + particulate autogenous bone graft (G), BS—particulate glass ceramic (180–212 μm) Biosilicate® (BS), and BS+G—particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (μCT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and μCT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate® are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation.

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Acknowledgments

The authors are grateful to Maira Cristina Rondina Couto for histology and imunohistochemical assistance. This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP/SP), Grant Numbers 2008/11485-8; 2009/17294-1.

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Authors and Affiliations

  1. Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil

    Rodrigo Ricci Vivan, Bruno Cavalini Cavenago & Marco Húngaro Duarte

  2. Oral Biology Master’s Program, Sagrado Coração University – USC, Rua Irmã Arminda 10-50, Baur, SP, 17011-160, Brazil

    Carlos Eduardo Mecca

  3. Oral Biology Doctoral’s Program, Bauru School of Dentistry, University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil

    Claudia Cristina Biguetti

  4. Department of Bioscience, Federal University of Sao Paulo, Campus Baixada Santista – UNIFESP, Avenida Ana Costa, 95, Santos, SP, 11060-001, Brazil

    Ana Claudia Muniz Rennó

  5. Department of Basic Sciences, Araçatuba School of Dentistry, São Paulo State University, FOA/UNESP, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil

    Roberta Okamoto & Mariza Akemi Matsumoto

  6. Oral Biology Doctoral’s Program, Sagrado Coração University, USC, Bauru, Brazil

    Mariza Akemi Matsumoto

  7. CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Brasília, Brazil

    Roberta Okamoto

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  1. Rodrigo Ricci Vivan
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  2. Carlos Eduardo Mecca
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  3. Claudia Cristina Biguetti
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  4. Ana Claudia Muniz Rennó
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Correspondence to Mariza Akemi Matsumoto.

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Vivan, R.R., Mecca, C.E., Biguetti, C.C. et al. Experimental maxillary sinus augmentation using a highly bioactive glass ceramic. J Mater Sci: Mater Med 27, 41 (2016). https://doi.org/10.1007/s10856-015-5652-7

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  • DOI: https://doi.org/10.1007/s10856-015-5652-7

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