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Biocompatibility of antibacterial Ti–Cu sintered alloy: in vivo bone response

  • Biocompatibility Studies
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Abstract

Ti–10Cu sintered alloy has shown very strong in vitro and in vivo antibacterial property and in vitro cell compatibility. In this paper, Ti–10Cu implant (Ti–Cu group) and commercial pure Ti implant (cp-Ti group) were implanted in rabbit femurs to investigate in vivo bone response to the Ti–10Cu alloy. X-ray photo, fluorescent microscopy, routine pathological examination and immunohistochemistry have been used to analyze bone growth, mineral apposition rate (MAR), bone implant contact (BIC), BMP-2 expression and TGF-β1 expression. In both Ti–Cu and cp-Ti groups, new bone tissue was found at bone/implant interfaces 4 weeks postimplantation and completely filled the interfaces gap bone 12 weeks postimplantation. A significant MOD value in BMP-2 expression was observed at week 1 and week 4 in the Ti–Cu group with lower values of week 2 and 3 in both groups, which indicated strong positive activity. MOD value in TGF-β1 expression decreased with the extension of implantation. However, no difference can be found in MAR, BIC and TGF-β1 expression between the two groups at all intervals. It was deduced that Ti–Cu alloy exhibited as good bone response as cp-Ti. The good bone compatibility suggests that Ti–10Cu alloy might have potential application in orthopedic surgery and dental implant.

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Acknowledgments

The authors would like to acknowledge the financial support from National Natural Science Foundation (81071262, 31271024, 31470930), Foundation for Key Program of Ministry of Education, China (313014), and Funding from Northeastern University (985 program and N141008001, LZ2014018), China.

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Authors and Affiliations

  1. Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang, 110001, People’s Republic of China

    Bing Bai

  2. Key Laboratory for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, P. O. Box 350, Shenyang, 110819, People’s Republic of China

    Erlin Zhang

  3. Jiamusi University, Jiamusi, 154007, People’s Republic of China

    Hui Dong & Jie Liu

  4. Department of Prosthodontics, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, People’s Republic of China

    Jie Liu

Authors
  1. Bing Bai
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  2. Erlin Zhang
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  3. Hui Dong
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  4. Jie Liu
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Correspondence to Bing Bai or Erlin Zhang.

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Bai, B., Zhang, E., Dong, H. et al. Biocompatibility of antibacterial Ti–Cu sintered alloy: in vivo bone response. J Mater Sci: Mater Med 26, 265 (2015). https://doi.org/10.1007/s10856-015-5600-6

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  • DOI: https://doi.org/10.1007/s10856-015-5600-6

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