Skip to main content

Advertisement

SpringerLink
Log in

Oxygen diffusion in marine-derived tissue engineering scaffolds

  • Tissue Engineering Constructs and Cell Substrates
  • Original Research
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

This paper addresses the computation of the effective diffusivity in new bioactive glass (BG) based tissue engineering scaffolds. High diffusivities facilitate the supply of oxygen and nutrients to grown tissue as well as the rapid disposal of toxic waste products. The present study addresses required novel types of bone tissue engineering BG scaffolds that are derived from natural marine sponges. Using the foam replication method, the scaffold geometry is defined by the porous structure of Spongia Agaricina and Spongia Lamella. These sponges present the advantage of attaining scaffolds with higher mechanical properties (2–4 MPa) due to a decrease in porosity (68–76 %). The effective diffusivities of these structures are compared with that of conventional scaffolds based on polyurethane (PU) foam templates, characterised by high porosity (>90 %) and lower mechanical properties (>0.05 MPa). Both the spatial and directional variations of diffusivity are investigated. Furthermore, the effect of scaffold decomposition due to immersion in simulated body fluid (SBF) on the diffusivity is addressed. Scaffolds based on natural marine sponges are characterised by lower oxygen diffusivity due to their lower porosity compared with the PU replica foams, which should enable the best oxygen supply to newly formed bone according the numerical results. The oxygen diffusivity of these new BG scaffolds increases over time as a consequence of the degradation in SBF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F. Bone fracture healing: cell therapy in delayed unions and nonunions. Bone. 2015;70:93–101.

    Article  Google Scholar 

  2. Stevens MM. Biomaterials for bone tissue engineering. Mater Today. 2008;11:18–25.

    Article  Google Scholar 

  3. Mulvana H. New materials and technologies for healthcare. In: Hench LL, Jones JR, Fenn MB, editors. London: Imperial College Press; 2011, p. 520, ISBN: 978-1-84816-558-8; Ultrasound in medicine & biology. vol. 40; 2//2014. p. 457.

  4. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21(24):2529–43.

    Article  Google Scholar 

  5. Gerhardt L-C, Boccaccini AR. Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials. 2010;3:3867–910.

    Article  Google Scholar 

  6. Polak JM, Hench LL, Kemp P. Future strategies for tissue and organ replacement. Singapore: World Scientific Publishing Company; 2002.

    Book  Google Scholar 

  7. Hench LL. The story of bioglass. J Mater Sci Mater Med. 2006;2006(17):967–78.

    Article  Google Scholar 

  8. Jones JR. Review of bioactive glass: from Hench to hybrids. Acta Biomater. 2013;9:4457–86.

    Article  Google Scholar 

  9. Gorustovich AA, Roether JA, Boccaccini AR. Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. Tissue Eng Part B. 2009;16(2):199–207.

    Article  Google Scholar 

  10. Chen QZ, Thompson ID, Boccaccini AR. 45S4 Bioglass-derived glass ceramic scaffolds for bone tissue engineering. Biomaterials. 2006;27:2414–25.

    Article  Google Scholar 

  11. Cunningham E, Dunne N, Clarke S, Choi SY, Walker G, Wilcox R, et al. Comparative characterization of 3-D hydroxyapatite scaffolds developed via replication of synthetic polymer foams and natural marine sponges. J Tissue Sci Eng. 2011. doi:10.4172/2157-7552.S1-001.

    Google Scholar 

  12. Karande TS. Effect of scaffold architecture on diffusion of oxygen in tissue engineering constructs. PhD, The University of Texas at Austin, 2007.

  13. Kang TY, Kang HW, Hwang CM, Leel SJ, Park J, Yoo JJ, et al. The realistic prediction of oxygen transport in a tissue-engineered scaffold by introducing time-varying effective diffusion coefficients. Acta Biomater. 2011;7:3345–53.

    Article  Google Scholar 

  14. Fiedler T, Belova IV, Murch GE, Jones JR, Roether JA, Boccaccini AR. A comparative study of oxygen diffusion in tissue engineering scaffolds. J Mater Sci Mater Med. 2014;25:2573–8.

    Article  Google Scholar 

  15. Pronzato R, Manconi R. Mediterranean commercial sponges: over 5000 years of natural history and cultural heritage. Mar Ecol. 2008;29:146–66.

    Article  Google Scholar 

  16. Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering—traditional factors. Tissue Eng. 2001;7:679–89.

    Article  Google Scholar 

  17. Mastrogiacomo M, Scaglione S, Martinetti R, Dolcini L, Beltrame F, Cancedda R, et al. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials. 2006;27:3230–7.

    Article  Google Scholar 

  18. Boccardi E, Philippart A, Juhasz-Bortuzzo JA, Novajra G, Vitale-Brovarone C, Boccaccini AR. Characterisation of Bioglass®-based foams developed via replication of natural marine sponges. Adv. Appl Ceram. 2015 (accepted for publication).

  19. Hench L, Wilson J. Surface-active biomaterials. Science. 1984;226:630–6.

    Article  Google Scholar 

  20. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 2006;27:2907–15.

    Article  Google Scholar 

  21. Fiedler T, Belova IV, Rawson A, Murch GE. Optimized lattice Monte Carlo for thermal analysis of composite. Comput Mater Sci. 2014;95:207–12.

    Article  Google Scholar 

  22. Belova IV, Murch GE, Fiedler T, Öchsner A. Lattice-based walks and the Monte Carlo method for addressing mass, thermal and elasticity problems. Defect Diffus Forum. 2008;283–286:3–23.

    Google Scholar 

  23. Fiedler T, Belova IV, Murch GE. Theoretical and lattice Monte Carlo analyses on thermal conduction in cellular metals. Comput Mater Sci. 2010;50:503–9.

    Article  Google Scholar 

  24. Fiedler T, Belova IV, Öchsner A, Murch GE. A review on thermal lattice Monte Carlo analysis. In: Delgado JM, editor. Current trends in chemical engineering. Houston: Studium Press LCC; 2010. p. 105–30.

    Google Scholar 

  25. Solorzano E, Reglero JA, Rodríguez-Perez MA, Lehmhus D, Wichmann M, De Saja JA. An experimental study on the thermal conductivity of aluminium foams by using the transient plane source method. Int J Heat Mass Transf. 2008;51:6259–67.

    Article  Google Scholar 

  26. Maxwell JC. A treatise on elasticity and magnetism. Oxford: Clarendon Press; 1892.

    Google Scholar 

  27. Dulnev GN. Heat transfer through solid disperse systems. J Eng Phys. 1965;9:275–9.

    Article  Google Scholar 

  28. Doube M, Kłosowski MM, Arganda-Carreras I, Cordeliéres F, Dougherty RP, Jackson J, et al. BoneJ: free and extensible bone image analysis in ImageJ. Bone. 2010;47:1076–9.

    Article  Google Scholar 

Download references

Acknowledgments

This research was supported under the Australian Research Council Discovery Projects funding scheme (Project Number DP130101377). In addition, this research was carried out in the framework of the EU ITN FP-7 Project “GlaCERCo”. The authors would like to acknowledge its financial support.

Author information

Authors and Affiliations

  1. Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058, Erlangen, Germany

    E. Boccardi & A. R. Boccaccini

  2. School of Engineering, University of Newcastle, Callaghan, NSW, 2287, Australia

    I. V. Belova, G. E. Murch & T. Fiedler

Authors
  1. E. Boccardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Belova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. E. Murch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. R. Boccaccini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Fiedler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Fiedler.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boccardi, E., Belova, I.V., Murch, G.E. et al. Oxygen diffusion in marine-derived tissue engineering scaffolds. J Mater Sci: Mater Med 26, 200 (2015). https://doi.org/10.1007/s10856-015-5531-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10856-015-5531-2

Keywords

Search

Navigation