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Biomedical electrosurgery devices containing nanostructure for minimally invasive surgery: reduction of thermal injury and acceleration of wound healing for liver cancer

  • Clinical Applications of Biomaterials
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Abstract

The aim of the present study was to investigate the thermal injury in the liver after a minimally invasive electrosurgery technique with a copper-doped diamond-like carbon (DLC-Cu) surface coating. To effectively utilize electrosurgery in a clinical caner setting, it is necessary to suppress the thermal injury to adjacent tissues. The surface morphologies of DLC-Cu thin films were characterized using scanning electron microscopy and transmission electron microscopy. Three-dimensional liver models were reconstructed using magnetic resonance imaging to simulate the electrosurgical procedure. Our results indicated that the temperature decreased significantly when minimally electrosurgery with nanostructured DLC-Cu thin films was used, and that it continued to decrease with increasing film thickness. In an animal model, thermography revealed that the surgical temperature was significantly lower in the minimally invasive electrosurgery with DLC-Cu thin film (DLC-Cu-SS) compared to untreated electrosurgery. In addition, DLC-Cu-SS created a relatively small thermal injury area and lateral thermal effect. These results indicated that the biomedical nanostructure coating reduced excessive thermal injury, and uniformly distributed temperature in the liver.

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Acknowledgments

The authors would like to thank the Department of Health, Executive Yuan, Taiwan for financially supporting this research under contract No. MOHW103-TDU-N-211-133001 and No. MOHW103-TD-B-111-01 (Health and welfare surcharge of tobacco products). The authors would also like to thank the International Congress of Oral Implantologists under contract No. A-101-057 for financially supporting this research.

Conflict of interest

The author declared that they have no conflict of interests.

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, Taipei Medical University Hospital, Taipei, 110, Taiwan

    Wen-Tien Hsiao

  2. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan

    Wen-Tien Hsiao & Li-Hsiang Lin

  3. Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan

    Wen-Tien Hsiao, Li-Hsiang Lin, Hsi-Jen Chiang, Keng-Liang Ou & Han-Yi Cheng

  4. School of Dental Technology, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei, 110, Taiwan

    Hsi-Jen Chiang

  5. Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Taipei, 235, Taiwan

    Hsi-Jen Chiang & Keng-Liang Ou

  6. Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, 110, Taiwan

    Keng-Liang Ou & Han-Yi Cheng

  7. Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, 110, Taiwan

    Keng-Liang Ou & Han-Yi Cheng

Authors
  1. Wen-Tien Hsiao
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  2. Li-Hsiang Lin
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  3. Hsi-Jen Chiang
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  4. Keng-Liang Ou
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  5. Han-Yi Cheng
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Corresponding authors

Correspondence to Keng-Liang Ou or Han-Yi Cheng.

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Li-Hsiang Lin is Co-first author.

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Hsiao, WT., Lin, LH., Chiang, HJ. et al. Biomedical electrosurgery devices containing nanostructure for minimally invasive surgery: reduction of thermal injury and acceleration of wound healing for liver cancer. J Mater Sci: Mater Med 26, 77 (2015). https://doi.org/10.1007/s10856-015-5416-4

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  • DOI: https://doi.org/10.1007/s10856-015-5416-4

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