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Biomimetic CaP coating incorporated with parathyroid hormone improves the osseointegration of titanium implant

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Abstract

Parathyroid hormone (PTH) is a well-known therapeutic agent for osteoporosis treatment, however, the inconvenience of daily administration and side effect from systematic administration severely limits its application in clinic. PTH has been incorporated into a biomimetic calcium phosphate (CaP) coating via a co-precipitation method in a modified simulated body fluid. The aim of the current study is to evaluate the osseointegration response of PTH incorporated CaP coating on titanium implants. Implants with different doses of PTH were inserted into tibiae of mice and evaluated by X-ray, micro-CT, histology and back-scattered scanning electron microscopy. Improved osseointegration of the implants loaded with PTH was observed compared to CaP coating only after 28 days of implantation in mouse tibiae. Micro-CT analysis showed better bone integration around the implant incorporated with PTH. Bone area and bone contact evaluations have demonstrated that peri-implant bone regeneration is highly dependent on the dosage of PTH incorporated. The higher the PTH content, the more bone formed surrounding the implant. Therefore, our results suggest that biomimetic CaP coating could be a useful a carrier for PTH local delivery, which results in improved bone-to-implant integration.

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Acknowledgments

The authors would like to thank Vilmaris Diaz-Doran and Dr. Douglas Adams for their assistance with Micro-CT. We would also like to thank Dr. Manshan Xu for his help for histological samples preparation. This work was supported by the National Science Foundation (BES 0503315).

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Authors and Affiliations

  1. Department of Chemical, Materials & Biomolecular Engineering, University of Connecticut, 97 North Eagleville Road, U-3136, Storrs, CT, 06269, USA

    Xiaohua Yu & Mei Wei

  2. Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA

    Liping Wang, Xi Jiang & David Rowe

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  1. Xiaohua Yu
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Correspondence to Mei Wei.

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Yu, X., Wang, L., Jiang, X. et al. Biomimetic CaP coating incorporated with parathyroid hormone improves the osseointegration of titanium implant. J Mater Sci: Mater Med 23, 2177–2186 (2012). https://doi.org/10.1007/s10856-012-4682-7

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  • DOI: https://doi.org/10.1007/s10856-012-4682-7

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