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Cytocompatibility of calcium phosphate coatings deposited by an ArF pulsed laser

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Abstract

In the current studies, we deposited ultra-thin hydroxyapatite films on a pure titanium substrate by pulsed laser deposition, and we examined the effects of these surfaces on rat bone marrow (RBM) cells. This method allowed deposition of 500-, 2,000-, and 5,000-Å-thick hydroxyapatite films. X-ray diffraction showed that the amorphous films recrystallized to a hydroxyapatite crystal structure after annealing. The proliferation of RBM cells was unaffected by the hydroxyapatite films, but osteocalsin and alkaline phosphatase mRNA and protein levels were elevated in cells grown on 2,000- and 5,000-Å-thick films. These results indicate that ultra-thin hydroxyapatite films generated by pulsed laser deposition are better at promoting osteogenesis than pure titanium surfaces.

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Acknowledgements

This study was supported by a grant from the Wakayama Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence of the Japan Science and Technology Agency and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Authors and Affiliations

  1. Department of Biomaterials, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata-shi, Osaka, 5731121, Japan

    Y. Hashimoto & M. Nakamura

  2. Department of Electronic System and Information Engineering, School of Biology-Oriented Science and Technology, Kinki University, 930 Nishimitani, Uchita-cho, Naga-gun, Wakayama, 6496493, Japan

    M. Kawashima, R. Hatanaka, M. Kusunoki, H. Nishikawa & S. Hontsu

Authors
  1. Y. Hashimoto
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  2. M. Kawashima
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  3. R. Hatanaka
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  4. M. Kusunoki
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  5. H. Nishikawa
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  6. S. Hontsu
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  7. M. Nakamura
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Correspondence to Y. Hashimoto.

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Hashimoto, Y., Kawashima, M., Hatanaka, R. et al. Cytocompatibility of calcium phosphate coatings deposited by an ArF pulsed laser. J Mater Sci: Mater Med 19, 327–333 (2008). https://doi.org/10.1007/s10856-006-0107-9

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  • DOI: https://doi.org/10.1007/s10856-006-0107-9

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