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Tyrosine derived polycarbonate membrane is useful for guided bone regeneration in rabbit mandibular defects

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Abstract

Standardized bilateral through-and-through defects (12 × 6 mm) were created extraorally in the mandibular angle of 18 New Zealand White rabbits. Animals were divided in to three groups (n = 6) according to the intended healing time. On the left side, defects were covered with a poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane wrapped around the inferior border of the mandible and fixed with bioabsorbable sutures. On the right side, the defects were filled with a mesh made of bioactive glass 13–93 and 3 wt% chitosan. The defects were covered with the same membranes. Periosteal flap was sutured over the membrane. Radiographically, bone ingrowth was seen in all specimens at 12 weeks postoperatively. At 24 weeks, completely ossified area remained approximately at the same level as at 12 weeks, but the non-ossified area decreased to almost zero. However, the bioactive glass mesh did not improve the results. Nevertheless, enveloping the defect with PDTE carbonate membrane seemed to play a crucial role in new bone formation. Based on these results, we conclude that tyrosine polycarbonate is a promising new material for guided bone regeneration.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki, Finland

    A. J. Asikainen, J. Noponen, C. Lindqvist & R. Suuronen

  2. Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Helsinki, Finland

    K. Mesimäki, J. Peltola, C. Lindqvist & R. Suuronen

  3. Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

    O. Laitinen

  4. Institute of Biomaterials, Tampere University of Technology, Tampere, Finland

    M. Pelto, M. Kellomäki & N. Ashammakhi

  5. Department of Oral Radiology, University of Helsinki, Helsinki, Finland

    J. Peltola

  6. Department of Surgery, Oulu University Hospital, Oulu, Finland

    N. Ashammakhi

  7. Institute for Regenerative Medicine, Tampere University and University Hospital, Tampere, Finland

    N. Ashammakhi & R. Suuronen

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  1. A. J. Asikainen
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  2. J. Noponen
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  3. K. Mesimäki
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  4. O. Laitinen
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  5. J. Peltola
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  6. M. Pelto
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  7. M. Kellomäki
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  8. N. Ashammakhi
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  9. C. Lindqvist
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  10. R. Suuronen
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Asikainen, A.J., Noponen, J., Mesimäki, K. et al. Tyrosine derived polycarbonate membrane is useful for guided bone regeneration in rabbit mandibular defects. J Mater Sci: Mater Med 16, 753–758 (2005). https://doi.org/10.1007/s10856-005-2613-6

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  • DOI: https://doi.org/10.1007/s10856-005-2613-6

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