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Recent advances in electrochemical nonenzymatic hydrogen peroxide sensors based on nanomaterials: a review

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Abstract

The development of efficient electrochemical hydrogen peroxide (H2O2) sensors has received great attention due to the significance of H2O2 in biological systems and its practical applications in various fields. With the new class of H2O2 sensors, the nonenzymatic detection of the target can provide many attractive characteristics, such as simple fabrication, ultrahigh sensitivity, and excellent stability. Considering the rapid expansion of nonenzymatic H2O2 detection using advanced nanomaterials, an overview of the current state of methods for electrochemical nonenzymatic H2O2 sensors is presented (with 399 refs.). The first part of the review covers the sensors based on the use of nanoparticles consisting of metals, metal oxides/sulfides, and bimetallic nanoparticles/alloys. The next major section discusses sensors that make use of carbon nanomaterials, such as carbon nanotubes, graphene, graphene oxide, carbon dots, and of other carbonaceous materials. Advantages and the intrinsic drawbacks of employing various nanomaterials to detect H2O2 are emphasized.

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References

  1. Giorgio M et al (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 8(9):722–728

    Google Scholar 

  2. Buczyński A et al (1993) Changes in antioxidant enzymes activities, aggregability and malonyldialdehyde concentration in blood platelets from patients with coronary heart disease. Atherosclerosis 100(2):223–228

    Google Scholar 

  3. Glaser R, Kiecolt-Glaser JK (1998) Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome. Am J Med 105(3):35S–42S

    Google Scholar 

  4. Jenner P, Jenner P (1991) Oxidative stress as a cause of Parkinson’s disease. Acta Neurol Scand 84(S136):6–15

    Google Scholar 

  5. Jenner P et al (1992) Oxidative stress as a cause of nigral cell death in Parkinson’s disease and incidental Lewy body disease. Ann Neurol 32(S1):S82–S87

    Google Scholar 

  6. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40(4):405–412

    Google Scholar 

  7. Szatrowski TP, Nathan CF (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Can Res 51(3):794–798

    Google Scholar 

  8. Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239–247

    Google Scholar 

  9. Kojda G, Harrison D (1999) Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 43(3):652–671

    Google Scholar 

  10. Wilson R, Turner A (1992) Glucose oxidase: an ideal enzyme. Biosens Bioelectron 7(3):165–185

    Google Scholar 

  11. Seki M et al (2004) Hydrogen peroxide production in Streptococcus pyogenes: involvement of lactate oxidase and coupling with aerobic utilization of lactate. J Bacteriol 186(7):2046–2051

    Google Scholar 

  12. Hurdis E, Romeyn H (1954) Accuracy of determination of hydrogen peroxide by cerate oxidimetry. Anal Chem 26(2):320–325

    Google Scholar 

  13. Klassen NV, Marchington D, McGowan HC (1994) H2O2 determination by the I3-method and by KMnO4 titration. Anal Chem 66(18):2921–2925

    Google Scholar 

  14. Eisenberg G (1943) Colorimetric determination of hydrogen peroxide. Ind Eng Chem Anal Ed 15(5):327–328

    Google Scholar 

  15. Tsuda M, Tatano T (1981) Method and reagent for the quantitative determination of hydrogen peroxide and precursors thereof. Google Patents

  16. Gubitz G et al (1985) Immobilized fluorophores in dynamic chemiluminescence detection of hydrogen peroxide. Anal Chem 57(11):2071–2074

    Google Scholar 

  17. Tahirović A et al (2007) A chemiluminescence sensor for the determination of hydrogen peroxide. Talanta 72(4):1378–1385

    Google Scholar 

  18. Beers RF, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195(1):133–140

    Google Scholar 

  19. Nogueira RFP, Oliveira MC, Paterlini WC (2005) Simple and fast spectrophotometric determination of H2O2 in photo-Fenton reactions using metavanadate. Talanta 66(1):86–91

    Google Scholar 

  20. Pinkernell U, Effkemann S, Karst U (1997) Simultaneous HPLC determination of peroxyacetic acid and hydrogen peroxide. Anal Chem 69(17):3623–3627

    Google Scholar 

  21. Khan SS et al (2000) A fluorescence-based imaging-fiber electrode chemical sensor for hydrogen peroxide. Anal Chim Acta 404(2):213–221

    Google Scholar 

  22. Oh W-K et al (2012) Fluorescent polymer nanoparticle for selective sensing of intracellular hydrogen peroxide. ACS Nano 6(10):8516–8524

    Google Scholar 

  23. Matsubara C, Kawamoto N, Takamura K (1992) Oxo [5, 10, 15, 20-tetra (4-pyridyl) porphyrinato] titanium(IV): an ultra-high sensitivity spectrophotometric reagent for hydrogen peroxide. Analyst 117(11):1781–1784

    Google Scholar 

  24. Yang C et al (2015) Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: a review. Anal Chim Acta 887:17–37

    Google Scholar 

  25. Song Y et al (2016) Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials. Biosens Bioelectron 76:195–212

    Google Scholar 

  26. Wang Z, Dai Z (2015) Carbon nanomaterial-based electrochemical biosensors: an overview. Nanoscale 7(15):6420–6431

    Google Scholar 

  27. Kuila T et al (2011) Recent advances in graphene-based biosensors. Biosens Bioelectron 26(12):4637–4648

    Google Scholar 

  28. Lawal AT (2015) Synthesis and utilisation of graphene for fabrication of electrochemical sensors. Talanta 131:424–443

    Google Scholar 

  29. Vashist SK, Luong JHT (2015) Recent advances in electrochemical biosensing schemes using graphene and graphene-based nanocomposites. Carbon 84:519–550

    Google Scholar 

  30. Wu S et al (2013) Graphene-based electrochemical sensors. Small 9(8):1160–1172

    Google Scholar 

  31. Chen W et al (2012) Recent advances in electrochemical sensing for hydrogen peroxide: a review. Analyst 137(1):49–58

    Google Scholar 

  32. Chen S et al (2013) Electrochemical sensing of hydrogen peroxide using metal nanoparticles: a review. Microchim Acta 180(1):15–32

    Google Scholar 

  33. Zhang R, Chen W (2017) Recent advances in graphene-based nanomaterials for fabricating electrochemical hydrogen peroxide sensors. Biosens Bioelectron 89:249–268

    Google Scholar 

  34. Wang J, Lin Y, Chen L (1993) Organic-phase biosensors for monitoring phenol and hydrogen peroxide in pharmaceutical antibacterial products. Analyst 118(3):277–280

    Google Scholar 

  35. Usui Y, Sato K, Tanaka M (2003) Catalytic dihydroxylation of olefins with hydrogen peroxide: an organic-solvent-and metal-free system. Angew Chem Int Ed 42(45):5623–5625

    Google Scholar 

  36. Lindgren A et al (2000) Biosensors based on novel peroxidases with improved properties in direct and mediated electron transfer. Biosens Bioelectron 15(9–10):491–497

    Google Scholar 

  37. Tatsuma T, Okawa Y, Watanabe T (1989) Enzyme monolayer-and bilayer-modified tin oxide electrodes for the determination of hydrogen peroxide and glucose. Anal Chem 61(21):2352–2355

    Google Scholar 

  38. Tao W et al (2005) An amperometric hydrogen peroxide sensor based on immobilization of hemoglobin in poly (o-aminophenol) film at iron–cobalt hexacyanoferrate-modified gold electrode. Anal Biochem 338(2):332–340

    Google Scholar 

  39. Qian J et al (1995) Characterization of regenerated silk fibroin membrane for immobilizing peroxidase and construction of an amperometric hydrogen peroxide sensor employing phenazine methosulphate as electron shuttle. J Electroanal Chem 397(1–2):157–162

    Google Scholar 

  40. Liu H et al (1997) Reagentless amperometric biosensors highly sensitive to hydrogen peroxide, glucose and lactose based on N-methyl phenazine methosulfate incorporated in a Nafion film as an electron transfer mediator between horseradish peroxidase and an electrode. Anal Chim Acta 344(3):187–199

    Google Scholar 

  41. Wendzinski F et al (1997) Highly sensitive determination of hydrogen peroxide and peroxidase with tetrathiafulvalene-based electrodes and the application in immunosensing. Biosens Bioelectron 12(1):43–52

    Google Scholar 

  42. Cao Z et al (2008) A third-generation hydrogen peroxide biosensor based on horseradish peroxidase immobilized in a tetrathiafulvalene–tetracyanoquinodimethane/multiwalled carbon nanotubes film. Biosens Bioelectron 24(2):222–227

    Google Scholar 

  43. Nakabayashi Y, Yoshikawa H (2000) Amperometric biosensors for sensing of hydrogen peroxide based on electron transfer between horseradish peroxidase and ferrocene as a mediator. Anal Sci 16(6):609–613

    Google Scholar 

  44. Şenel M, Çevik E, Abasıyanık MF (2010) Amperometric hydrogen peroxide biosensor based on covalent immobilization of horseradish peroxidase on ferrocene containing polymeric mediator. Sens Actuators B Chem 145(1):444–450

    Google Scholar 

  45. Wang L, Wang E (2004) A novel hydrogen peroxide sensor based on horseradish peroxidase immobilized on colloidal Au modified ITO electrode. Electrochem Commun 6(2):225–229

    Google Scholar 

  46. Gooding JJ (2005) Nanostructuring electrodes with carbon nanotubes: a review on electrochemistry and applications for sensing. Electrochim Acta 50(15):3049–3060

    Google Scholar 

  47. Hosseini H et al (2014) Nonenzymatic glucose and hydrogen peroxide sensors based on catalytic properties of palladium nanoparticles/poly(3, 4-ethylenedioxythiophene) nanofibers. Sens Actuators B Chem 195:85–91

    Google Scholar 

  48. Maduraiveeran G, Ramaraj R (2007) Gold nanoparticles embedded in silica sol–gel matrix as an amperometric sensor for hydrogen peroxide. J Electroanal Chem 608(1):52–58

    Google Scholar 

  49. Xuan J, Jiang L-P, Zhu J-J (2010) Nonenzymatic hydrogen peroxide sensor based on three-dimensional ordered macroporous gold film modified electrode. Chin J Anal Chem 38:513–516

    Google Scholar 

  50. Hall SB, Khudaish EA, Hart AL (1998) Electrochemical oxidation of hydrogen peroxide at platinum electrodes. Part 1. An adsorption-controlled mechanism. Electrochim Acta 43(5–6):579–588

    Google Scholar 

  51. Liu Z-M et al (2005) A hydrogen peroxide biosensor based on nano-Au/PAMAM dendrimer/cystamine modified gold electrode. Sens Actuators B Chem 106(1):394–400

    Google Scholar 

  52. Guascito MR et al (2008) A new amperometric nanostructured sensor for the analytical determination of hydrogen peroxide. Biosens Bioelectron 24(4):1057–1063

    Google Scholar 

  53. Gutes A et al (2010) Palladium nanostructures from galvanic displacement as hydrogen peroxide sensor. Sens Actuators B Chem 147(2):681–686

    Google Scholar 

  54. Batchelor-McAuley C et al (2008) The use of copper(II) oxide nanorod bundles for the non-enzymatic voltammetric sensing of carbohydrates and hydrogen peroxide. Sens Actuators B Chem 135(1):230–235

    Google Scholar 

  55. Yan Q et al (2012) Nickel hydroxide modified silicon nanowires electrode for hydrogen peroxide sensor applications. Electrochim Acta 61:148–153

    Google Scholar 

  56. Pang P et al (2014) Nonenzymatic amperometric determination of hydrogen peroxide by graphene and gold nanorods nanocomposite modified electrode. J Electroanal Chem 727:27–33

    Google Scholar 

  57. Lee K-S, El-Sayed MA (2006) Gold and silver nanoparticles in sensing and imaging: sensitivity of plasmon response to size, shape, and metal composition. J Phys Chem B 110(39):19220–19225

    Google Scholar 

  58. Jain PK et al (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110(14):7238–7248

    Google Scholar 

  59. Daniel M-C, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1):293–346

    Google Scholar 

  60. Yang Y et al (2014) Enhanced charge transfer by gold nanoparticle at DNA modified electrode and its application to label-free DNA detection. ACS Appl Mater Interfaces 6(10):7579–7584

    Google Scholar 

  61. Bernalte E et al (2013) Characterisation of screen-printed gold and gold nanoparticle-modified carbon sensors by electrochemical impedance spectroscopy. J Electroanal Chem 709:70–76

    Google Scholar 

  62. Thenmozhi K, Narayanan SS (2007) Electrochemical sensor for H2O2 based on thionin immobilized 3-aminopropyltrimethoxy silane derived sol–gel thin film electrode. Sens Actuators B Chem 125(1):195–201

    Google Scholar 

  63. Ni P et al (2013) Facile synthesis of Prussian blue@ gold nanocomposite for nonenzymatic detection of hydrogen peroxide. RSC Adv 3(36):15987–15992

    Google Scholar 

  64. Banerjee S, Sarkar P, Turner AP (2013) Amperometric biosensor based on Prussian Blue nanoparticle-modified screen-printed electrode for estimation of glucose-6-phosphate. Anal Biochem 439(2):194–200

    Google Scholar 

  65. Janyasupab M et al (2011) Bimetallic Pt–Ru nanoparticle catalyst for hydrogen peroxide detection. J Nanotechnol 2011:1–6

    Google Scholar 

  66. Zhang Y et al (2012) Improvement of amperometric biosensor performance for H2O2 detection based on bimetallic PtM (M = Ru, Au, and Ir) nanoparticles. Int J Electrochem 2012:1–8

    Google Scholar 

  67. Wang J et al (2014) Nanoporous PtAu alloy as an electrochemical sensor for glucose and hydrogen peroxide. Sens Actuators B Chem 191:612–618

    Google Scholar 

  68. Manivannan S, Ramaraj R (2009) Core-shell Au/Ag nanoparticles embedded in silicate sol–gel network for sensor application towards hydrogen peroxide. J Chem Sci 121(5):735–743

    Google Scholar 

  69. Miao Y-E et al (2013) A novel hydrogen peroxide sensor based on Ag/SnO2 composite nanotubes by electrospinning. Electrochim Acta 99:117–123

    Google Scholar 

  70. Lu X et al (2014) A novel nonenzymatic hydrogen peroxide sensor based on three-dimensional porous Ni foam modified with a Pt electrocatalyst. Anal Methods 6(1):235–241

    Google Scholar 

  71. Han J-H et al (2006) Electrochemical oxidation of hydrogen peroxide at nanoporous platinum electrodes and the application to glutamate microsensor. Electrochim Acta 52(4):1788–1791

    Google Scholar 

  72. Cui X et al (2008) Low-potential sensitive hydrogen peroxide detection based on nanotubular TiO2 and platinum composite electrode. Electroanal Int J Devoted Fundam Pract Asp Electroanal 20(9):970–975

    Google Scholar 

  73. Li J et al (2010) Direct electrocatalytic reduction of hydrogen peroxide at a glassy carbon electrode modified with polypyrrole nanowires and platinum hollow nanospheres. Microchim Acta 171(1):125–131

    Google Scholar 

  74. Wan J et al (2012) Nonenzymatic H2O2 sensor based on Pt nanoflower electrode. J Cluster Sci 23(4):1061–1068

    Google Scholar 

  75. Heli H et al (2014) Enhanced electrocatalytic reduction and highly sensitive nonenzymatic detection of hydrogen peroxide using platinum hierarchical nanoflowers. Sens Actuators B Chem 192:310–316

    Google Scholar 

  76. Katsounaros I et al (2012) Hydrogen peroxide electrochemistry on platinum: towards understanding the oxygen reduction reaction mechanism. Phys Chem Chem Phys 14(20):7384–7391

    Google Scholar 

  77. Welch CM et al (2005) Silver nanoparticle assemblies supported on glassy-carbon electrodes for the electro-analytical detection of hydrogen peroxide. Anal Bioanal Chem 382(1):12–21

    Google Scholar 

  78. Song Y et al (2009) The electrodeposition of Ag nanoparticles on a type I collagen-modified glassy carbon electrode and their applications as a hydrogen peroxide sensor. Nanotechnology 20(10):105501

    Google Scholar 

  79. Zhao B et al (2009) Silver microspheres for application as hydrogen peroxide sensor. Electrochem Commun 11(8):1707–1710

    Google Scholar 

  80. Lian W et al (2009) A hydrogen peroxide sensor based on electrochemically roughened silver electrodes. Electrochim Acta 54(18):4334–4339

    Google Scholar 

  81. Tian J, Liu S, Sun X (2010) Supramolecular microfibrils of o-phenylenediamine dimers: oxidation-induced morphology change and the spontaneous formation of Ag nanoparticle decorated nanofibers. Langmuir 26(19):15112–15116

    Google Scholar 

  82. Lu W et al (2012) Supramolecular microfibrils of o-phenylenediamine dimers: oxidation-induced formation of Au nanoparticle-decorated nanoplates for H2O2 detection. Current Nanoscience 8(2):221–225

    Google Scholar 

  83. Ning R et al (2012) A novel strategy to synthesize Au nanoplates and their application for enzymeless H2O2 detection. Electrochim Acta 60:13–16

    Google Scholar 

  84. Zhang M-R, Chen X-Q, Pan G-B (2017) Electrosynthesis of gold nanoparticles/porous GaN electrode for non-enzymatic hydrogen peroxide detection. Sens Actuators B Chem 240:142–147

    Google Scholar 

  85. Pournaghi-Azar MH, Ahour F, Pournaghi-Azar F (2010) Simple and rapid amperometric monitoring of hydrogen peroxide in salivary samples of dentistry patients exploiting its electro-reduction on the modified/palladized aluminum electrode as an improved electrocatalyst. Sen Actuators B Chem 145(1):334–339

    Google Scholar 

  86. Jiang F et al (2013) A one-pot ‘green’ synthesis of Pd-decorated PEDOT nanospheres for nonenzymatic hydrogen peroxide sensing. Biosens Bioelectron 44:127–131

    Google Scholar 

  87. Patella B et al (2017) A nanostructured sensor of hydrogen peroxide. Sens Actuators B Chem 245:44–54

    Google Scholar 

  88. Yang X et al (2013) A sensitive hydrogen peroxide and glucose biosensor based on gold/silver core–shell nanorods. Electrochim Acta 108:39–44

    Google Scholar 

  89. Li X et al (2014) A nonenzymatic hydrogen peroxide sensor based on Au–Ag nanotubes and chitosan film. J Electroanal Chem 735:19–23

    Google Scholar 

  90. Li Z, Zheng X, Zheng J (2016) A non-enzymatic sensor based on Au@ Ag nanoparticles with good stability for sensitive detection of H2O2. New J Chem 40(3):2115–2120

    Google Scholar 

  91. Lin C-Y et al (2010) Electrode modified with a composite film of ZnO nanorods and Ag nanoparticles as a sensor for hydrogen peroxide. Talanta 82(1):340–347

    Google Scholar 

  92. Xu C et al (2011) Nanoporous PtAg and PtCu alloys with hollow ligaments for enhanced electrocatalysis and glucose biosensing. Biosens Bioelectron 27(1):160–166

    Google Scholar 

  93. Evans SA et al (2002) Detection of hydrogen peroxide at mesoporous platinum microelectrodes. Anal Chem 74(6):1322–1326

    Google Scholar 

  94. You T et al (2003) Characterization of platinum nanoparticle-embedded carbon film electrode and its detection of hydrogen peroxide. Anal Chem 75(9):2080–2085

    Google Scholar 

  95. Karam P, Halaoui LI (2008) Sensing of H2O2 at low surface density assemblies of Pt nanoparticles in polyelectrolyte. Anal Chem 80(14):5441–5448

    Google Scholar 

  96. Cui K et al (2008) A novel hydrogen peroxide sensor based on Ag nanoparticles electrodeposited on DNA-networks modified glassy carbon electrode. Electrochem Commun 10(4):663–667

    Google Scholar 

  97. Li Y et al (2010) Fabrication of a novel nonenzymatic hydrogen peroxide sensor based on Se/Pt nanocomposites. Electrochem Commun 12(6):777–780

    Google Scholar 

  98. Kumar SA, Wang S-F, Chang Y-T (2010) Poly(BCB)/Au-nanoparticles hybrid film modified electrode: preparation, characterization and its application as a non-enzymatic sensor. Thin Solid Films 518(20):5832–5838

    Google Scholar 

  99. Qin X et al (2011) Synthesis of dendritic silver nanostructures and their application in hydrogen peroxide electroreduction. Electrochim Acta 56(9):3170–3174

    Google Scholar 

  100. Lu W et al (2011) Hydrothermal synthesis of well-stable silver nanoparticles and their application for enzymeless hydrogen peroxide detection. Electrochim Acta 56(5):2295–2298

    Google Scholar 

  101. Tian J et al (2011) Preparation of Ag nanoparticle-decorated poly (m-phenylenediamine) microparticles and their application for hydrogen peroxide detection. Analyst 136(9):1806–1809

    Google Scholar 

  102. Chen H et al (2011) A hydrogen peroxide sensor based on Ag nanoparticles electrodeposited on natural nano-structure attapulgite modified glassy carbon electrode. Talanta 86:266–270

    Google Scholar 

  103. Yin J et al (2011) A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated silicon nanowire arrays. Electrochim Acta 56(11):3884–3889

    Google Scholar 

  104. Meng F et al (2011) Nanoporous gold as non-enzymatic sensor for hydrogen peroxide. Electrochim Acta 56(12):4657–4662

    Google Scholar 

  105. Qin X et al (2012) Green photocatalytic synthesis of Ag nanoparticle-decorated TiO2 nanowires for nonenzymatic amperometric H2O2 detection. Electrochim Acta 74:275–279

    Google Scholar 

  106. Liang F, Jia M, Hu J (2012) Pt-implanted indium tin oxide electrodes and their amperometric sensor applications for nitrite and hydrogen peroxide. Electrochim Acta 75:414–419

    Google Scholar 

  107. Yang X et al (2012) Hydrogen peroxide and glucose biosensor based on silver nanowires synthesized by polyol process. Analyst 137(18):4362–4367

    Google Scholar 

  108. Han J, Ma J, Ma Z (2013) One-step synthesis of poly(thionine)-Au nano-network and nanowires and its application for non-enzyme biosensing of hydrogen peroxide. Electrochem Commun 33:47–50

    Google Scholar 

  109. Khan MM et al (2013) Novel Ag@TiO2 nanocomposite synthesized by electrochemically active biofilm for nonenzymatic hydrogen peroxide sensor. Mater Sci Eng C 33(8):4692–4699

    Google Scholar 

  110. Wang Q, Yun Y (2013) Nonenzymatic sensor for hydrogen peroxide based on the electrodeposition of silver nanoparticles on poly(ionic liquid)-stabilized graphene sheets. Microchim Acta 180(3):261–268

    Google Scholar 

  111. Su J et al (2013) A novel 3-D fabrication of platinum nanoparticles decorated micro carbon pillars electrode for high sensitivity detection of hydrogen peroxide. Sens Actuators B Chem 181:57–64

    Google Scholar 

  112. Lu H et al (2013) Nonenzymatic hydrogen peroxide electrochemical sensor based on carbon-coated SnO2 supported Pt nanoparticles. Colloids Surf B 101:106–110

    Google Scholar 

  113. Guascito MR et al (2013) Te oxide nanowires as advanced materials for amperometric nonenzymatic hydrogen peroxide sensing. Talanta 115:863–869

    Google Scholar 

  114. Wang Y et al (2013) High sensitivity hydrogen peroxide and hydrazine sensor based on silver nanocubes with rich 100 facets as an enhanced electrochemical sensing platform. Biosens Bioelectron 43:180–185

    Google Scholar 

  115. Kurowska E et al (2013) Silver nanowire array sensor for sensitive and rapid detection of H2O2. Electrochim Acta 104:439–447

    Google Scholar 

  116. Wang Q-M et al (2014) Facile synthesis of trilaminar core-shell Ag@C@Ag nanospheres and their application for H2O2 detection. Electrochim Acta 127:349–354

    Google Scholar 

  117. Xiong W, Qu Q, Liu S (2014) Self-assembly of ultra-small gold nanoparticles on an indium tin oxide electrode for the enzyme-free detection of hydrogen peroxide. Microchim Acta 181(9):983–989

    Google Scholar 

  118. Zhang Q-L et al (2014) Cytosine-assisted synthesis of gold nanochains and gold nanoflowers for the construction of a microperoxidase-11 based amperometric biosensor for hydrogen peroxide. Microchim Acta 181(11–12):1239–1247

    Google Scholar 

  119. Qin X et al (2015) A novel non-enzyme hydrogen peroxide sensor based on catalytic reduction property of silver nanowires. Talanta 139:56–61

    Google Scholar 

  120. Han T et al (2015) Monodisperse AuM (M = Pd, Rh, Pt) bimetallic nanocrystals for enhanced electrochemical detection of H2O2. Sens Actuators B Chem 207:404–412

    Google Scholar 

  121. Zhang S et al (2015) Novel glucose sensor with Au@Ag heterogeneous nanorods based on electrocatalytic reduction of hydrogen peroxide at negative potential. J Electroanal Chem 742:84–89

    Google Scholar 

  122. Li Y et al (2015) Synthesis of Ag@AgCl nanoboxes, and their application to electrochemical sensing of hydrogen peroxide at very low potential. Microchim Acta 182(1):61–68

    Google Scholar 

  123. Ensafi AA, Rezaloo F, Rezaei B (2016) Electrochemical sensor based on porous silicon/silver nanocomposite for the determination of hydrogen peroxide. Sens Actuators B Chem 231:239–244

    Google Scholar 

  124. Baccarin M et al (2016) Direct electrochemistry of hemoglobin and biosensing for hydrogen peroxide using a film containing silver nanoparticles and poly(amidoamine) dendrimer. Mater Sci Eng, C 58:97–102

    Google Scholar 

  125. Ngamaroonchote A et al (2017) Patterned gold electrode prepared from optical discs display largely enhanced electrochemical sensitivity as exemplified in a sensor for hydrogen peroxide. Microchim Acta 184(1):211–218

    Google Scholar 

  126. Ma B et al (2018) A sensitive electrochemical nonenzymatic biosensor for the detection of H2O2 released from living cells based on ultrathin concave Ag nanosheets. Biosens Bioelectron 106:29–36

    Google Scholar 

  127. Muthurasu A, Kim HY (2018) Facile electrochemical synthesis of three dimensional flowerlike gold microstructure for electrochemical oxidation of hydrogen peroxide. Electrochim Acta 283:1425–1431

    Google Scholar 

  128. Shi L et al (2018) An inkjet printed Ag electrode fabricated on plastic substrate with a chemical sintering approach for the electrochemical sensing of hydrogen peroxide. Sens Actuators B Chem 256:938–945

    Google Scholar 

  129. Liu W et al (2018) Pt and Au bimetallic and monometallic nanostructured amperometric sensors for direct detection of hydrogen peroxide: influences of bimetallic effect and silica support. Sens Actuators B Chem 255:1325–1334

    Google Scholar 

  130. Cheng W, Dong S, Wang E (2002) Gold nanoparticles as fine tuners of electrochemical properties of the electrode/solution interface. Langmuir 18(25):9947–9952

    Google Scholar 

  131. Parlak O, Turner AP, Tiwari A (2014) On/off-switchable zipper-like bioelectronics on a graphene interface. Adv Mater 26(3):482–486

    Google Scholar 

  132. Salimi A et al (2007) Nanomolar detection of hydrogen peroxide on glassy carbon electrode modified with electrodeposited cobalt oxide nanoparticles. Anal Chim Acta 594(1):24–31

    Google Scholar 

  133. Hou C et al (2012) Metal–organic framework templated synthesis of Co3O4 nanoparticles for direct glucose and H2O2 detection. Analyst 137(24):5803–5808

    Google Scholar 

  134. Xia S et al (2014) A model of interface-related enhancement based on the contrast between Co3O4 sphere and cube for electrochemical detection of hydrogen peroxide. Electrochem Commun 40:67–70

    Google Scholar 

  135. Wang M et al (2015) Highly sensitive H2O2 sensor based on Co3O4 hollow sphere prepared via a template-free method. Electrochim Acta 182:613–620

    Google Scholar 

  136. Wu W et al (2017) Synthesis of tremella-like CoS and its application in sensing of hydrogen peroxide and glucose. Mater Sci Eng, C 70:430–437

    Google Scholar 

  137. Miao X-M et al (2008) Direct electrocatalytic reduction of hydrogen peroxide based on Nafion and copper oxide nanoparticles modified Pt electrode. J Electroanal Chem 612(2):157–163

    Google Scholar 

  138. Song M-J, Hwang SW, Whang D (2010) Non-enzymatic electrochemical CuO nanoflowers sensor for hydrogen peroxide detection. Talanta 80(5):1648–1652

    Google Scholar 

  139. Ping J et al (2010) Copper oxide nanoparticles and ionic liquid modified carbon electrode for the non-enzymatic electrochemical sensing of hydrogen peroxide. Microchim Acta 171(1):117–123

    Google Scholar 

  140. Li S et al (2011) Enzyme-free amperometric sensing of hydrogen peroxide and glucose at a hierarchical Cu2O modified electrode. Talanta 85(3):1260–1264

    Google Scholar 

  141. Yang G, Chen F, Yang Z (2012) Electrocatalytic oxidation of hydrogen peroxide based on the shuttlelike nano-CuO-modified electrode. Int J Electrochem 2012:1–6

    Google Scholar 

  142. Gao P, Liu D (2015) Facile synthesis of copper oxide nanostructures and their application in non-enzymatic hydrogen peroxide sensing. Sens Actuators B Chem 208:346–354

    Google Scholar 

  143. Liu M, Liu R, Chen W (2013) Graphene wrapped Cu2O nanocubes: non-enzymatic electrochemical sensors for the detection of glucose and hydrogen peroxide with enhanced stability. Biosens Bioelectron 45:206–212

    Google Scholar 

  144. Dutta AK et al (2014) Non–enzymatic amperometric sensing of hydrogen peroxide at a CuS modified electrode for the determination of urine H2O2. Electrochim Acta 144:282–287

    Google Scholar 

  145. Li Y et al (2015) Carbon quantum dots/octahedral Cu2O nanocomposites for non-enzymatic glucose and hydrogen peroxide amperometric sensor. Sens Actuators B Chem 206:735–743

    Google Scholar 

  146. Kumar JS et al (2018) Novel synthesis of a Cu2O–graphene nanoplatelet composite through a two-step electrodeposition method for selective detection of hydrogen peroxide. New J Chem 42(5):3574–3581

    Google Scholar 

  147. Ojani R, Raoof J-B, Norouzi B (2012) An efficient sensor for determination of concentrated hydrogen peroxide based on nickel oxide modified carbon paste electrode. Int J Electrochem Sci 7:1852–1863

    Google Scholar 

  148. Akhtar N et al (2015) Fabrication of a highly selective nonenzymatic amperometric sensor for hydrogen peroxide based on nickel foam/cytochrome c modified electrode. Sens Actuators B Chem 207:158–166

    Google Scholar 

  149. Salazar P, Rico V, González-Elipe AR (2017) Non-enzymatic hydrogen peroxide detection at NiO nanoporous thin film-electrodes prepared by physical vapor deposition at oblique angles. Electrochim Acta 235:534–542

    Google Scholar 

  150. Achari DS et al (2017) A non-enzymatic sensor for hydrogen peroxide based on the use of α-Fe2O3 nanoparticles deposited on the surface of NiO nanosheets. Microchim Acta 184(9):3223–3229

    Google Scholar 

  151. Babu KJ et al (2014) The influences of shape and structure of MnO2 nanomaterials over the non-enzymatic sensing ability of hydrogen peroxide. J Nanopart Res 16(2):2250

    Google Scholar 

  152. Asif M et al (2015) Real-time tracking of hydrogen peroxide secreted by live cells using MnO2 nanoparticles intercalated layered doubled hydroxide nanohybrids. Anal Chim Acta 898:34–41

    Google Scholar 

  153. Cheng F-Y et al (2005) Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications. Biomaterials 26(7):729–738

    Google Scholar 

  154. Chen J et al (2005) α-Fe2O3 nanotubes in gas sensor and lithium-ion battery applications. Adv Mater 17(5):582–586

    Google Scholar 

  155. Dutta AK et al (2012) Peroxidase-like activity and amperometric sensing of hydrogen peroxide by Fe2O3 and Prussian Blue-modified Fe2O3 nanoparticles. J Mol Catal A Chem 360:71–77

    Google Scholar 

  156. Liu X et al (2013) α-Fe2O3 nanorod arrays for bioanalytical applications: nitrite and hydrogen peroxide detection. RSC Adv 3(22):8489–8494

    Google Scholar 

  157. Yang J et al (2011) A sensitive enzymeless hydrogen-peroxide sensor based on epitaxially-grown Fe3O4 thin film. Anal Chim Acta 708(1):44–51

    Google Scholar 

  158. Cao GS et al (2015) A sensitive nonenzymatic hydrogen peroxide sensor based on Fe3O4–Fe2O3 nanocomposites. Bull Mater Sci 38(1):163–167

    Google Scholar 

  159. Majumder S et al (2016) A highly sensitive non-enzymatic hydrogen peroxide and hydrazine electrochemical sensor based on 3D micro-snowflake architectures of α-Fe2O3. RSC Adv 6(65):59907–59918

    Google Scholar 

  160. Cai J et al (2018) In situ electrodeposition of mesoporous aligned α-Fe2O3 nanoflakes for highly sensitive nonenzymatic H2O2 sensor. Appl Surf Sci 456:302–306

    Google Scholar 

  161. Gu A et al (2010) An unusual H2O2 electrochemical sensor based on Ni(OH)2 nanoplates grown on Cu substrate. Electrochim Acta 55(24):7182–7187

    Google Scholar 

  162. Xu C, Wang J, Zhou J (2013) Nanoporous PtNi alloy as an electrochemical sensor for ethanol and H2O2. Sens Actuators B Chem 182:408–415

    Google Scholar 

  163. Saha B et al (2015) Selective growth of Co-electrodeposited Mn2O3-Au spherical composite network towards enhanced non-enzymatic hydrogen peroxide sensing. Electrochim Acta 174:853–863

    Google Scholar 

  164. Janyasupab M et al (2013) Bimetallic Pt–M (M = Cu, Ni, Pd, and Rh) nanoporous for H2O2 based amperometric biosensors. Sens Actuators B Chem 179:209–214

    Google Scholar 

  165. Zhang Y et al (2013) Nonenzymatic hydrogen peroxide sensor based on a glassy carbon electrode modified with electrospun PdO–NiO composite nanofibers. Microchim Acta 180(11):1085–1091

    Google Scholar 

  166. Chirizzi D et al (2016) A novel nonenzymatic amperometric hydrogen peroxide sensor based on CuO@Cu2O nanowires embedded into poly(vinyl alcohol). Talanta 147:124–131

    Google Scholar 

  167. Tian L et al (2014) Fabrication of cubic PtCu nanocages and their enhanced electrocatalytic activity towards hydrogen peroxide. Nanosc Res Lett 9(1):68–72

    Google Scholar 

  168. Wang Y et al (2009) Peroxidase-like layered double hydroxide nanoflakes for electrocatalytic reduction of H2O2. Electroanalysis 21(19):2125–2132

    Google Scholar 

  169. Jia W et al (2009) Electrocatalytic oxidation and reduction of H2O2 on vertically aligned Co3O4 nanowalls electrode: toward H2O2 detection. J Electroanal Chem 625(1):27–32

    Google Scholar 

  170. Cao X et al (2010) A novel non-enzymatic hydrogen peroxide biosensor based on ultralong manganite MnOOH nanowires. Sens Actuators B Chem 147(2):730–734

    Google Scholar 

  171. Liu Z et al (2010) Novel nonenzymatic hydrogen peroxide sensor based on iron oxide–silver hybrid submicrospheres. Talanta 81(4):1650–1654

    Google Scholar 

  172. Kung C-W et al (2011) Synthesis of Co3O4 thin films by chemical bath deposition in the presence of different anions and application to H2O2 sensing. Procedia Eng 25:847–850

    Google Scholar 

  173. Cui L et al (2011) A mimic peroxidase biosensor based on calcined layered double hydroxide for detection of H2O2. Biosens Bioelectron 26(7):3278–3283

    Google Scholar 

  174. Dutta AK et al (2012) Synthesis of FeS and FeSe nanoparticles from a single source precursor: a study of their photocatalytic activity, peroxidase-like behavior, and electrochemical sensing of H2O2. ACS Appl Mater Interfaces 4(4):1919–1927

    Google Scholar 

  175. Magro M et al (2013) Electrochemical determination of hydrogen peroxide production by isolated mitochondria: a novel nanocomposite carbon–maghemite nanoparticle electrode. Sens Actuators B Chem 176:315–322

    Google Scholar 

  176. Wang Y-H et al (2013) A gold electrode modified with hemoglobin and the chitosan@ Fe3O4 nanocomposite particles for direct electrochemistry of hydrogen peroxide. Microchim Acta 180(7–8):659–667

    Google Scholar 

  177. Lee KK et al (2013) CoOOH nanosheet electrodes: simple fabrication for sensitive electrochemical sensing of hydrogen peroxide and hydrazine. Biosens Bioelectron 39(1):255–260

    Google Scholar 

  178. Xu C et al (2013) Nanoporous platinum–cobalt alloy for electrochemical sensing for ethanol, hydrogen peroxide, and glucose. Anal Chim Acta 780:20–27

    Google Scholar 

  179. Ensafi AA, Abarghoui MM, Rezaei B (2014) Electrochemical determination of hydrogen peroxide using copper/porous silicon based non-enzymatic sensor. Sens Actuators B Chem 196:398–405

    Google Scholar 

  180. Marimuthu T et al (2014) Synthesis and characterization of non-enzymatic hydrogen peroxide sensor of polypyrrole coated cobalt nanocomposites. Sens Actuators B Chem 202:1037–1043

    Google Scholar 

  181. Kuo C-C, Lan W-J, Chen C-H (2014) Redox preparation of mixed-valence cobalt manganese oxide nanostructured materials: highly efficient noble metal-free electrocatalysts for sensing hydrogen peroxide. Nanoscale 6(1):334–341

    Google Scholar 

  182. Cao GS et al (2014) Hydrogen peroxide electrochemical sensor based on Fe3O4 nanoparticles. Micro Nano Lett 9(1):16–18

    Google Scholar 

  183. Wang J et al (2014) Facile fabrication of nanoporous PdFe alloy for nonenzymatic electrochemical sensing of hydrogen peroxide and glucose. Anal Chim Acta 832:34–43

    Google Scholar 

  184. Liu T et al (2015) Non-enzymatic detection of hydrogen peroxide based on Fenton-type reaction on poly(azure A)-chitosan/Cu modified electrode. Electrochim Acta 182:742–750

    Google Scholar 

  185. Gu T-T et al (2015) Novel photoelectrochemical hydrogen peroxide sensor based on hemin sensitized nanoporous NiO based photocathode. J Electroanal Chem 759:27–31

    Google Scholar 

  186. Zhang J, Zheng J (2015) An enzyme-free hydrogen peroxide sensor based on Ag/FeOOH nanocomposites. Anal Methods 7(5):1788–1793

    Google Scholar 

  187. Zhang S, Sheng Q, Zheng J (2015) Synthesis of Ag–HNTs–MnO2 nanocomposites and their application for nonenzymatic hydrogen peroxide electrochemical sensing. RSC Adv 5(34):26878–26885

    Google Scholar 

  188. Song H et al (2015) Electrochemical hydrogen peroxide sensor based on a glassy carbon electrode modified with nanosheets of copper-doped copper(II) oxide. Microchim Acta 182(7):1543–1549

    Google Scholar 

  189. Gao P, Liu D (2015) Petal-like CuO nanostructures prepared by a simple wet chemical method, and their application to non-enzymatic amperometric determination of hydrogen peroxide. Microchim Acta 182(7):1231–1239

    Google Scholar 

  190. Wu W et al (2016) A novel nonenzymatic electrochemical sensor based on 3D flower-like Ni7S6 for hydrogen peroxide and glucose. Sens Actuators B Chem 232:633–641

    Google Scholar 

  191. Mei H et al (2016) Nonenzymatic electrochemical sensor based on Fe@Pt core–shell nanoparticles for hydrogen peroxide, glucose and formaldehyde. Sens Actuators B Chem 223:68–75

    Google Scholar 

  192. Mei L et al (2016) Non-enzymatic sensing of glucose and hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous copper, carbon black and nafion. Microchim Acta 183(4):1359–1365

    Google Scholar 

  193. Du S et al (2016) Vertical α-FeOOH nanowires grown on the carbon fiber paper as a free-standing electrode for sensitive H2O2 detection. Nano Res 9(8):2260–2269

    Google Scholar 

  194. Gao X et al (2016) Single crystal sub-nanometer sized Cu6(SR)6 clusters: structure, photophysical properties, and electrochemical sensing. Adv Sci 3(12):1600126

    Google Scholar 

  195. Li D et al (2017) Hydrogen peroxide sensing using Cu2O nanocubes decorated by Ag–Au alloy nanoparticles. J Alloys Compd 690:1–7

    Google Scholar 

  196. Zhao W et al (2017) Electrochemical hydrogen peroxide sensor based on carbon supported Cu@Pt core-shell nanoparticles. Mater Sci Eng C 78:185–190

    Google Scholar 

  197. Xiong X et al (2017) Ni2P nanosheets array as a novel electrochemical catalyst electrode for non-enzymatic H2O2 sensing. Electrochim Acta 253:517–521

    Google Scholar 

  198. Wu W et al (2017) Sulphides of the cobalt doped Ni7S6 type for glucose, hydrogen peroxide and nitrite sensing platform. Sens Actuators B Chem 250:224–232

    Google Scholar 

  199. Rajendra Kumar Reddy G, Kumar PS (2017) Template electrodeposition of high-performance copper oxide nanosensors for electrochemical analysis of hydrogen peroxide. Mater Sci Eng C 75:1480–1488

    Google Scholar 

  200. Gholivand M-B et al (2017) Introduction of a simple sensing device for monitoring of hydrogen peroxide based on ZnFe2O4 nanoparticles/chitosan modified gold electrode. J Electroanal Chem 796:17–23

    Google Scholar 

  201. Wu Z-L et al (2017) Binary cobalt and manganese oxides: amperometric sensing of hydrogen peroxide. Sens Actuators B Chem 253:949–957

    Google Scholar 

  202. Vasuki K et al (2017) Amperometric hydrogen peroxide sensor based on the use of CoFe2O4 hollow nanostructures. Microchim Acta 184(8):2579–2586

    Google Scholar 

  203. Jin J et al (2017) A glassy carbon electrode modified with FeS nanosheets as a highly sensitive amperometric sensor for hydrogen peroxide. Microchim Acta 184(5):1389–1396

    Google Scholar 

  204. Xu L et al (2017) Amperometric sensing of hydrogen peroxide via an ITO electrode modified with gold nanoparticles electrodeposited on a CoMn-layered double hydroxide. Microchim Acta 184(10):3989–3996

    Google Scholar 

  205. Shu Y et al (2017) Cube-like CoSn(OH)6 nanostructure for sensitive electrochemical detection of H2O2 in human serum sample. Sens Actuators B Chem 241:528–533

    Google Scholar 

  206. Wang L et al (2018) A novel non-enzymatic hydrogen peroxide sensor based on Co: ZnO modified electrodes. Prog Nat Sci Mater Int 28(1):24–27

    Google Scholar 

  207. Ke X et al (2018) Fabrication of Pt-ZnO composite nanotube modified electrodes for the detection of H2O2. J Electroanal Chem 817:176–183

    Google Scholar 

  208. Hooch Antink W et al (2018) Simple synthesis of CuO/Ag nanocomposite electrode using precursor ink for non-enzymatic electrochemical hydrogen peroxide sensing. Sens Actuators B Chem 255:1995–2001

    Google Scholar 

  209. Çelik Kazıcı H et al (2018) Microstructured prealloyed titanium-nickel powder as a novel nonenzymatic hydrogen peroxide sensor. J Colloid Interface Sci 530:353–360

    Google Scholar 

  210. Xie F et al (2018) Cobalt nitride nanowire array as an efficient electrochemical sensor for glucose and H2O2 detection. Sens and Actuators B Chem 255:1254–1261

    Google Scholar 

  211. Tao Y et al (2018) Highly sensitive nonenzymatic H2O2 sensor based on NiFe-layered double hydroxides nanosheets grown on Ni foam. Surf Interfaces 12:102–107

    Google Scholar 

  212. Guler M et al (2018) A novel nonenzymatic hydrogen peroxide amperometric sensor based on Pd@CeO2-NH2 nanocomposites modified glassy carbon electrode. Mater Sci Eng C 90:454–460

    Google Scholar 

  213. Kiani Shahvandi S, Ahmar H, Tabatabaei Rezaei SJ (2018) Palladium nanoparticles immobilized on polymer-functionalized magnetic nanoparticles for the determination of hydrogen peroxide. Surf Interfaces 12:71–77

    Google Scholar 

  214. Dai Y et al (2018) Morphology-dependent electrochemical behavior of 18-facet Cu7S4 nanocrystals based electrochemical sensing platform for hydrogen peroxide and prostate specific antigen. Biosens Bioelectron 112:143–148

    Google Scholar 

  215. Xia H et al (2018) Electrospun porous CuFe2O4 nanotubes on nickel foam for nonenzymatic voltammetric determination of glucose and hydrogen peroxide. J Alloys Compd 739:764–770

    Google Scholar 

  216. Yang K et al (2018) Magnetic Fe3O4 stacked sphere-like nanocomposite and its application as platform for H2O2 sensing. J Electroanal Chem 814:1–6

    Google Scholar 

  217. Xue B et al (2018) Ni foam-supported ZnO nanowires and Co3O4/NiCo2O4 double-shelled nanocages for efficient hydrogen peroxide detection. Sens Actuators B Chem 262:828–836

    Google Scholar 

  218. Ye D et al (2012) A novel nonenzymatic hydrogen peroxide sensor based on LaNi0.5Ti0.5O3/CoFe2O4 modified electrode. Colloids Surf B Biointerfaces 89:10–14

    Google Scholar 

  219. Zhang Z et al (2012) A novel nonenzymatic sensor based on LaNi0.6Co0.4O3 modified electrode for hydrogen peroxide and glucose. Anal Chim Acta 745:112–117

    Google Scholar 

  220. Zhang X et al (2013) Non-enzymatic hydrogen peroxide photoelectrochemical sensor based on WO3 decorated core–shell TiC/C nanofibers electrode. Electrochim Acta 108:491–496

    Google Scholar 

  221. He J et al (2017) High-performance non-enzymatic perovskite sensor for hydrogen peroxide and glucose electrochemical detection. Sens Actuators B Chem 244:482–491

    Google Scholar 

  222. Yu Z et al (2017) Photoelectrochemical sensing of hydrogen peroxide at zero working potential using a fluorine-doped tin oxide electrode modified with BiVO4 microrods. Microchim Acta 184(3):799–806

    Google Scholar 

  223. Kitte SA et al (2018) Determination of concentrated hydrogen peroxide free from oxygen interference at stainless steel electrode. Anal Chem 90:8680–8685

    Google Scholar 

  224. Düzenli D et al (2018) Synthesis and characterization of novel Ti doped hexagonal mesoporous silica catalyst for nonenzymatic hydrogen peroxide oxidation. Microporous Mesoporous Mater 257:92–98

    Google Scholar 

  225. Wang J, Musameh M, Lin Y (2003) Solubilization of carbon nanotubes by Nafion toward the preparation of amperometric biosensors. J Am Chem Soc 125(9):2408–2409

    Google Scholar 

  226. Wang J, Musameh M (2003) Carbon nanotube/teflon composite electrochemical sensors and biosensors. Anal Chem 75(9):2075–2079

    Google Scholar 

  227. Goran JM et al (2015) H2O2 detection at carbon nanotubes and nitrogen-doped carbon nanotubes: oxidation, reduction, or disproportionation? Anal Chem 87(12):5989–5996

    Google Scholar 

  228. Fang Y et al (2012) A non-enzymatic hydrogen peroxide sensor based on poly(vinyl alcohol)–multiwalled carbon nanotubes–platinum nanoparticles hybrids modified glassy carbon electrode. Electrochim Acta 70:266–271

    Google Scholar 

  229. Qu F et al (2005) Amperometric biosensor for choline based on layer-by-layer assembled functionalized carbon nanotube and polyaniline multilayer film. Anal Biochem 344(1):108–114

    Google Scholar 

  230. Santhosh P et al (2006) Fabrication of a new polyaniline grafted multi-wall carbon nanotube modified electrode and its application for electrochemical detection of hydrogen peroxide. Anal Chim Acta 575(1):32–38

    Google Scholar 

  231. Jin E et al (2012) Fabrication of multiwalled carbon nanotubes/polypyrrole/Prussian blue ternary composite nanofibers and their application for enzymeless hydrogen peroxide detection. J Mater Sci 47(10):4326–4331. https://doi.org/10.1007/s10853-012-6283-8

    Google Scholar 

  232. Fang B et al (2009) A novel hydrogen peroxide sensor based on multiwalled carbon nanotubes/poly (pyrocatechol violet)-modified glassy carbon electrode. J Appl Polym Sci 112(6):3488–3493

    Google Scholar 

  233. Lin K-C, Tsai T-H, Chen S-M (2010) Performing enzyme-free H2O2 biosensor and simultaneous determination for AA, DA, and UA by MWCNT–PEDOT film. Biosens Bioelectron 26(2):608–614

    Google Scholar 

  234. Wu Z et al (2007) Preparation and characterization of chitosan-grafted multiwalled carbon nanotubes and their electrochemical properties. Carbon 45(6):1212–1218

    Google Scholar 

  235. Liu Y et al (2005) Decoration of carbon nanotubes with chitosan. Carbon 43(15):3178–3180

    Google Scholar 

  236. Wen Z, Ci S, Li J (2009) Pt nanoparticles inserting in carbon nanotube arrays: nanocomposites for glucose biosensors. J Phys Chem C 113(31):13482–13487

    Google Scholar 

  237. You J-M, Kim D, Jeon S (2012) Electrocatalytic reduction of H2O2 by Pt nanoparticles covalently bonded to thiolated carbon nanostructures. Electrochim Acta 65:288–293

    Google Scholar 

  238. Li X et al (2014) High loading Pt nanoparticles on functionalization of carbon nanotubes for fabricating nonenzyme hydrogen peroxide sensor. Biosens Bioelectron 59:221–226

    Google Scholar 

  239. Zhao W et al (2009) A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode. Talanta 80(2):1029–1033

    Google Scholar 

  240. Pannopard P et al (2015) Size-tailored synthesis of gold nanoparticles and their facile deposition on AAO-templated carbon nanotubes via electrostatic self-assembly: application to H2O2 detection. Carbon 94:836–844

    Google Scholar 

  241. Shamsipur M et al (2012) A novel hydrogen peroxide sensor based on the direct electron transfer of catalase immobilized on nano-sized NiO/MWCNTs composite film. Electroanalysis 24(2):357–367

    Google Scholar 

  242. Chen K-J et al (2012) Bimetallic PtM (M = Pd, Ir) nanoparticle decorated multi-walled carbon nanotube enzyme-free, mediator-less amperometric sensor for H2O2. Biosens Bioelectron 33(1):120–127

    Google Scholar 

  243. Han Y, Zheng J, Dong S (2013) A novel nonenzymatic hydrogen peroxide sensor based on Ag–MnO2–MWCNTs nanocomposites. Electrochim Acta 90:35–43

    Google Scholar 

  244. Baghayeri M, Veisi H (2015) Fabrication of a facile electrochemical biosensor for hydrogen peroxide using efficient catalysis of hemoglobin on the porous Pd@Fe3O4-MWCNT nanocomposite. Biosens Bioelectron 74:190–198

    Google Scholar 

  245. Mei H et al (2015) Ultrasensitive electrochemical assay of hydrogen peroxide and glucose based on PtNi alloy decorated MWCNTs. RSC Adv 5(124):102877–102884

    Google Scholar 

  246. Morozov S et al (2008) Giant intrinsic carrier mobilities in graphene and its bilayer. Phys Rev Lett 100(1):016602

    Google Scholar 

  247. Bolotin KI et al (2008) Ultrahigh electron mobility in suspended graphene. Solid State Commun 146(9):351–355

    Google Scholar 

  248. Geim AK, Novoselov KS (2007) The rise of graphene. Nat Mater 6(3):183–191

    Google Scholar 

  249. Balandin AA et al (2008) Superior thermal conductivity of single-layer graphene. Nano Lett 8(3):902–907

    Google Scholar 

  250. Li D, Kaner RB (2008) Graphene-based materials. Nat Nanotechnol 3:101–105

    Google Scholar 

  251. Nair RR et al (2008) Fine structure constant defines visual transparency of graphene. Science 320(5881):1308

    Google Scholar 

  252. Zhou M, Zhai Y, Dong S (2009) Electrochemical sensing and biosensing platform based on chemically reduced graphene oxide. Anal Chem 81(14):5603–5613

    Google Scholar 

  253. Banks CE, Compton RG (2005) Exploring the electrocatalytic sites of carbon nanotubes for NADH detection: an edge plane pyrolytic graphite electrode study. Analyst 130(9):1232–1239

    Google Scholar 

  254. Banks CE et al (2004) Investigation of modified basal plane pyrolytic graphite electrodes: definitive evidence for the electrocatalytic properties of the ends of carbon nanotubes. Chem Commun 16:1804–1805

    Google Scholar 

  255. Chen C-W et al (2015) Sonoelectrochemical intercalation and exfoliation for the preparation of defective graphene sheets and their application as nonenzymatic H2O2 sensors and oxygen reduction catalysts. RSC Adv 5(28):21988–21998

    Google Scholar 

  256. Mutyala S, Mathiyarasu J (2016) A reagentless non-enzymatic hydrogen peroxide sensor presented using electrochemically reduced graphene oxide modified glassy carbon electrode. Mater Sci Eng C 69:398–406

    Google Scholar 

  257. Xu F et al (2011) Graphene-Pt nanocomposite for nonenzymatic detection of hydrogen peroxide with enhanced sensitivity. Electrochem Commun 13(10):1131–1134

    Google Scholar 

  258. Zhang Y et al (2014) Highly sensitive graphene–Pt nanocomposites amperometric biosensor and its application in living cell H2O2 detection. Anal Chem 86(19):9459–9465

    Google Scholar 

  259. Yuan B et al (2014) Polyethylenimine-bridged graphene oxide–gold film on glassy carbon electrode and its electrocatalytic activity toward nitrite and hydrogen peroxide. Sens Actuators B Chem 198:55–61

    Google Scholar 

  260. Zhang Y et al (2013) Electrochemical behavior of graphene/Nafion/Azure I/Au nanoparticles composites modified glass carbon electrode and its application as nonenzymatic hydrogen peroxide sensor. Electrochim Acta 90:550–555

    Google Scholar 

  261. Dhara K et al (2016) Au nanoparticles decorated reduced graphene oxide for the fabrication of disposable nonenzymatic hydrogen peroxide sensor. J Electroanal Chem 764:64–70

    Google Scholar 

  262. Priya C, Sivasankari G, Sriman Narayanan S (2012) Electrochemical behavior of Azure A/gold nanoclusters modified electrode and its application as non-enzymatic hydrogen peroxide sensor. Colloids Surf B Biointerfaces 97:90–96

    Google Scholar 

  263. Jia N et al (2014) A simple non-enzymatic hydrogen peroxide sensor using gold nanoparticles-graphene-chitosan modified electrode. Sens Actuators B Chem 195:165–170

    Google Scholar 

  264. Tian C et al (2018) Preparation of gold nanoparticles supported on graphene oxide with flagella as the template for nonenzymatic hydrogen peroxide sensing. Anal Bioanal Chem 410:5915–5921

    Google Scholar 

  265. Zhao B et al (2013) Construction of 3D electrochemically reduced graphene oxide–silver nanocomposite film and application as nonenzymatic hydrogen peroxide sensor. Electrochem Commun 27:1–4

    Google Scholar 

  266. Liu S et al (2010) Stable aqueous dispersion of graphene nanosheets: noncovalent functionalization by a polymeric reducing agent and their subsequent decoration with Ag nanoparticles for enzymeless hydrogen peroxide detection. Macromolecules 43(23):10078–10083

    Google Scholar 

  267. Liu S et al (2011) A method for the production of reduced graphene oxide using benzylamine as a reducing and stabilizing agent and its subsequent decoration with Ag nanoparticles for enzymeless hydrogen peroxide detection. Carbon 49(10):3158–3164

    Google Scholar 

  268. Zhong L et al (2013) Electrochemically controlled growth of silver nanocrystals on graphene thin film and applications for efficient nonenzymatic H2O2 biosensor. Electrochim Acta 89:222–228

    Google Scholar 

  269. Babu RS, Prabhu P, Narayanan SS (2014) Enzyme-free selective determination of H2O2 and glucose using functionalized CuNP-modified graphite electrode in room temperature ionic liquid medium. RSC Adv 4(88):47497–47504

    Google Scholar 

  270. Xu F et al (2013) Electrochemical behavior of cuprous oxide–reduced graphene oxide nanocomposites and their application in nonenzymatic hydrogen peroxide sensing. Electrochim Acta 88:59–65

    Google Scholar 

  271. Gao W et al (2014) Highly sensitive nonenzymatic glucose and H2O2 sensor based on Ni(OH)2/electroreduced graphene oxide–multiwalled carbon nanotube film modified glass carbon electrode. Talanta 120:484–490

    Google Scholar 

  272. Li L et al (2010) A novel nonenzymatic hydrogen peroxide sensor based on MnO2/graphene oxide nanocomposite. Talanta 82(5):1637–1641

    Google Scholar 

  273. Karuppiah C et al (2014) A novel enzymatic glucose biosensor and sensitive non-enzymatic hydrogen peroxide sensor based on graphene and cobalt oxide nanoparticles composite modified glassy carbon electrode. Sens Actuators B Chem 196:450–456

    Google Scholar 

  274. Mani V et al (2015) Electrodeposition of copper nanoparticles using pectin scaffold at graphene nanosheets for electrochemical sensing of glucose and hydrogen peroxide. Electrochim Acta 176:804–810

    Google Scholar 

  275. Moozarm Nia P, Woi PM, Alias Y (2017) Facile one-step electrochemical deposition of copper nanoparticles and reduced graphene oxide as nonenzymatic hydrogen peroxide sensor. Appl Surf Sci 413:56–65

    Google Scholar 

  276. Liu W et al (2015) A non-enzymatic hydrogen peroxide sensor based on vertical NiO nanosheets supported on the graphite sheet. J Electroanal Chem 749:62–67

    Google Scholar 

  277. Hao C et al (2016) Preparation and characterization of Fe2O3 nanoparticles by solid-phase method and its hydrogen peroxide sensing properties. ACS Sustain Chem Eng 4(3):1069–1077

    Google Scholar 

  278. Ensafi AA, Jafari-Asl M, Rezaei B (2013) A novel enzyme-free amperometric sensor for hydrogen peroxide based on Nafion/exfoliated graphene oxide–Co3O4 nanocomposite. Talanta 103:322–329

    Google Scholar 

  279. Zhang X et al (2016) Hydrothermal synthesis of cobalt oxide porous nanoribbons anchored with reduced graphene oxide for hydrogen peroxide detection. J Nanopart Res 18(8):232

    Google Scholar 

  280. Ramachandran K et al (2017) MnO2 nanorods grown NGNF nanocomposites for the application of highly sensitive and selective electrochemical detection of hydrogen peroxide. J Ind Eng Chem 46:19–27

    Google Scholar 

  281. Wu Z-L et al (2017) MnO2/reduced graphene oxide nanoribbons: facile hydrothermal preparation and their application in amperometric detection of hydrogen peroxide. Sens Actuators B Chem 239:544–552

    Google Scholar 

  282. Wang L et al (2013) Manganese dioxide based ternary nanocomposite for catalytic reduction and nonenzymatic sensing of hydrogen peroxide. Electrochim Acta 114:416–423

    Google Scholar 

  283. Wang L et al (2015) Highly sensitive electrochemical biosensor for evaluation of oxidative stress based on the nanointerface of graphene nanocomposites blended with gold, Fe3O4, and platinum nanoparticles. ACS Appl Mater Interfaces 7(33):18441–18449

    Google Scholar 

  284. Yang X et al (2016) In situ & controlled preparation of platinum nanoparticles dopping into graphene sheets@cerium oxide nanocomposites sensitized screen printed electrode for nonenzymatic electrochemical sensing of hydrogen peroxide. J Electroanal Chem 777:85–91

    Google Scholar 

  285. Yao Z et al (2016) Synthesis of differently sized silver nanoparticles on a screen-printed electrode sensitized with a nanocomposites consisting of reduced graphene oxide and cerium(IV) oxide for nonenzymatic sensing of hydrogen peroxide. Microchim Acta 183(10):2799–2806

    Google Scholar 

  286. Yang Z et al (2016) Sensing hydrogen peroxide with a glassy carbon electrode modified with silver nanoparticles, AlOOH and reduced graphene oxide. Microchim Acta 183(3):1131–1136

    Google Scholar 

  287. Thanh TD et al (2016) Novel porous gold-palladium nanoalloy network-supported graphene as an advanced catalyst for non-enzymatic hydrogen peroxide sensing. Biosens Bioelectron 85:669–678

    Google Scholar 

  288. Wu Q, Sheng Q, Zheng J (2016) Nonenzymatic amperometric sensing of hydrogen peroxide using a glassy carbon electrode modified with a sandwich-structured nanocomposite consisting of silver nanoparticles, Co3O4 and reduced graphene oxide. Microchim Acta 183(6):1943–1951

    Google Scholar 

  289. Huang Y et al (2018) Non-enzymatic electrochemical hydrogen peroxide biosensor based on reduction graphene oxide-persimmon tannin-platinum nanocomposite. Mater Sci Eng C 92:590–598

    Google Scholar 

  290. Zhai M et al (2015) Nanocomposite of Au nanoparticles/helical carbon nanofibers and application in hydrogen peroxide biosensor. J Nanosci Nanotechnol 15(6):4682–4687

    Google Scholar 

  291. Li C et al (2016) Facile synthesis of electrospinning Mn2O3–Fe2O3 loaded carbon fibers for electrocatalysis of hydrogen peroxide reduction and hydrazine oxidation. Electrochim Acta 211:255–264

    Google Scholar 

  292. Chen J et al (2016) A glassy carbon electrode modified with a nanocomposite consisting of carbon nanohorns and poly(2-aminopyridine) for non-enzymatic amperometric determination of hydrogen peroxide. Microchim Acta 183(12):3237–3242

    Google Scholar 

  293. Liu M, He S, Chen W (2014) Co3O4 nanowires supported on 3D N-doped carbon foam as an electrochemical sensing platform for efficient H2O2 detection. Nanoscale 6(20):11769–11776

    Google Scholar 

  294. Liu S et al (2014) Low temperature thermal treatment of hexamethylenetetramine to synthesize nitrogen-doped carbon for non-enzymatic H2O2 sensing. Sens Actuators B Chem 201:240–245

    Google Scholar 

  295. Lyu Y-P et al (2018) Hydrothermal and plasma nitrided electrospun carbon nanofibers for amperometric sensing of hydrogen peroxide. Microchim Acta 185(8):371

    Google Scholar 

  296. Wu Y-S et al (2018) A comparison of nitrogen-doped sonoelectrochemical and chemical graphene nanosheets as hydrogen peroxide sensors. Ultrason Sonochem 42:659–664

    Google Scholar 

  297. Wang Q, Yun Y, Zheng J (2009) Nonenzymatic hydrogen peroxide sensor based on a polyaniline-single walled carbon nanotubes composite in a room temperature ionic liquid. Microchim Acta 167(3):153–157

    Google Scholar 

  298. Bo X et al (2010) Nonenzymatic amperometric sensor of hydrogen peroxide and glucose based on Pt nanoparticles/ordered mesoporous carbon nanocomposite. Talanta 82(1):85–91

    Google Scholar 

  299. Bo X et al (2010) In situ growth of copper sulfide nanoparticles on ordered mesoporous carbon and their application as nonenzymatic amperometric sensor of hydrogen peroxide. Talanta 81(1):339–345

    Google Scholar 

  300. Haghighi B, Hamidi H, Gorton L (2010) Electrochemical behavior and application of Prussian blue nanoparticle modified graphite electrode. Sens Actuators B Chem 147(1):270–276

    Google Scholar 

  301. Salimi A et al (2011) A novel non-enzymatic hydrogen peroxide sensor based on single walled carbon nanotubes–manganese complex modified glassy carbon electrode. Electrochim Acta 56(9):3387–3394

    Google Scholar 

  302. Shi Y et al (2011) Carbon nanotube decorated with silver nanoparticles via noncovalent interaction for a novel nonenzymatic sensor towards hydrogen peroxide reduction. J Electroanal Chem 656(1):29–33

    Google Scholar 

  303. Lu W et al (2011) Method for effective immobilization of Ag nanoparticles/graphene oxide composites on single-stranded DNA modified gold electrode for enzymeless H2O2 detection. J Mater Sci 46(15):5260–5266. https://doi.org/10.1007/s10853-011-5464-1

    Google Scholar 

  304. Qin X et al (2012) One-step synthesis of Ag nanoparticles-decorated reduced graphene oxide and their application for H2O2 detection. Electrochim Acta 79:46–51

    Google Scholar 

  305. Xiao F et al (2012) Growth of metal–metal oxide nanostructures on freestanding graphene paper for flexible biosensors. Adv Func Mater 22(12):2487–2494

    Google Scholar 

  306. Lata S et al (2012) An amperometric H2O2 biosensor based on cytochrome c immobilized onto nickel oxide nanoparticles/carboxylated multiwalled carbon nanotubes/polyaniline modified gold electrode. Process Biochem 47(6):992–998

    Google Scholar 

  307. Palanisamy S, Cheemalapati S, Chen S-M (2012) Highly sensitive and selective hydrogen peroxide biosensor based on hemoglobin immobilized at multiwalled carbon nanotubes–zinc oxide composite electrode. Anal Biochem 429(2):108–115

    Google Scholar 

  308. Palanisamy S, Chen S-M, Sarawathi R (2012) A novel nonenzymatic hydrogen peroxide sensor based on reduced graphene oxide/ZnO composite modified electrode. Sens Actuators B Chem 166–167:372–377

    Google Scholar 

  309. Niu X et al (2012) Platinum nanoparticle-decorated carbon nanotube clusters on screen-printed gold nanofilm electrode for enhanced electrocatalytic reduction of hydrogen peroxide. Electrochim Acta 65:97–103

    Google Scholar 

  310. Wang Z et al (2012) One-step unipolar pulse electrodeposition of nickel hexacyanoferrate/chitosan/carbon nanotubes film and its application in hydrogen peroxide sensor. Sens Actuators B Chem 162(1):353–360

    Google Scholar 

  311. Han KN et al (2012) Development of Pt/TiO2 nanohybrids-modified SWCNT electrode for sensitive hydrogen peroxide detection. Sens Actuators B Chem 174:406–413

    Google Scholar 

  312. Zhong H et al (2012) Non-enzymatic hydrogen peroxide amperometric sensor based on a glassy carbon electrode modified with an MWCNT/polyaniline composite film and platinum nanoparticles. Microchim Acta 176(3):389–395

    Google Scholar 

  313. Ye Y et al (2012) Enhanced nonenzymatic hydrogen peroxide sensing with reduced graphene oxide/ferroferric oxide nanocomposites. Talanta 89:417–421

    Google Scholar 

  314. Li S-J et al (2012) Electrostatic self-assembly for preparation of sulfonated graphene/gold nanoparticle hybrids and their application for hydrogen peroxide sensing. Electrochim Acta 85:628–635

    Google Scholar 

  315. Zheng L et al (2013) Preparation of cobalt-tetraphenylporphyrin/reduced graphene oxide nanocomposite and its application on hydrogen peroxide biosensor. Anal Chim Acta 768:69–75

    Google Scholar 

  316. Chen X-M et al (2013) Ultrafine palladium nanoparticles grown on graphene nanosheets for enhanced electrochemical sensing of hydrogen peroxide. Electrochim Acta 97:398–403

    Google Scholar 

  317. Golsheikh AM et al (2013) One-step electrodeposition synthesis of silver-nanoparticle-decorated graphene on indium-tin-oxide for enzymeless hydrogen peroxide detection. Carbon 62:405–412

    Google Scholar 

  318. Tian J et al (2013) Ultrathin graphitic carbon nitride nanosheets: a low-cost, green, and highly efficient electrocatalyst toward the reduction of hydrogen peroxide and its glucose biosensing application. Nanoscale 5(19):8921–8924

    Google Scholar 

  319. Zhang Y et al (2014) Fabrication of 2D ordered mesoporous carbon nitride and its use as electrochemical sensing platform for H2O2, nitrobenzene, and NADH detection. Biosens Bioelectron 53:250–256

    Google Scholar 

  320. Li J et al (2014) A novel hydrogen peroxide biosensor based on hemoglobin-collagen-CNTs composite nanofibers. Colloids Surf B 118:77–82

    Google Scholar 

  321. Heli H, Pishahang J (2014) Cobalt oxide nanoparticles anchored to multiwalled carbon nanotubes: synthesis and application for enhanced electrocatalytic reaction and highly sensitive nonenzymatic detection of hydrogen peroxide. Electrochim Acta 123:518–526

    Google Scholar 

  322. Zhan B et al (2014) A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated three-dimensional graphene. Appl Phys Lett 104(24):243704

    Google Scholar 

  323. Husmann S, Nossol E, Zarbin AJG (2014) Carbon nanotube/Prussian blue paste electrodes: characterization and study of key parameters for application as sensors for determination of low concentration of hydrogen peroxide. Sens Actuators B Chem 192:782–790

    Google Scholar 

  324. Babu KJ, Nahm KS, Hwang YJ (2014) A facile one-pot green synthesis of reduced graphene oxide and its composites for non-enzymatic hydrogen peroxide sensor applications. RSC Adv 4(16):7944–7951

    Google Scholar 

  325. Butwong N et al (2014) A sensitive nonenzymatic hydrogen peroxide sensor using cadmium oxide nanoparticles/multiwall carbon nanotube modified glassy carbon electrode. J Electroanal Chem 717–718:41–46

    Google Scholar 

  326. Habibi B, Jahanbakhshi M (2014) A novel nonenzymatic hydrogen peroxide sensor based on the synthesized mesoporous carbon and silver nanoparticles nanohybrid. Sens Actuators B Chem 203:919–925

    Google Scholar 

  327. Zhu X et al (2014) Doping ionic liquid into Prussian blue-multiwalled carbon nanotubes modified screen-printed electrode to enhance the nonenzymatic H2O2 sensing performance. Sens Actuators B Chem 195:274–280

    Google Scholar 

  328. Jiang B-B et al (2014) A non-enzymatic hydrogen peroxide sensor based on a glassy carbon electrode modified with cuprous oxide and nitrogen-doped graphene in a nafion matrix. Microchim Acta 181(11–12):1463–1470

    Google Scholar 

  329. He S et al (2014) Non-enzymatic hydrogen peroxide electrochemical sensor based on a three-dimensional MnO2 nanosheets/carbon foam composite. RSC Adv 4(90):49315–49323

    Google Scholar 

  330. Wang H et al (2015) Well-dispersed cobalt phthalocyanine nanorods on graphene for the electrochemical detection of hydrogen peroxide and glucose sensing. Sens Actuators B Chem 216:298–306

    Google Scholar 

  331. Sahin OG (2015) Microwave-assisted synthesis of PtAu@C based bimetallic nanocatalysts for non-enzymatic H2O2 sensor. Electrochim Acta 180:873–878

    Google Scholar 

  332. Moozarm Nia P et al (2015) A novel non-enzymatic H2O2 sensor based on polypyrrole nanofibers–silver nanoparticles decorated reduced graphene oxide nano composites. Appl Surf Sci 332:648–656

    Google Scholar 

  333. Liu J et al (2015) Highly exposed Pt nanoparticles supported on porous graphene for electrochemical detection of hydrogen peroxide in living cells. Biosens Bioelectron 74:71–77

    Google Scholar 

  334. Sun Y et al (2015) Real-time electrochemical detection of hydrogen peroxide secretion in live cells by Pt nanoparticles decorated graphene–carbon nanotube hybrid paper electrode. Biosens Bioelectron 68:358–364

    Google Scholar 

  335. Lorestani F et al (2015) One-step hydrothermal green synthesis of silver nanoparticle-carbon nanotube reduced-graphene oxide composite and its application as hydrogen peroxide sensor. Sens Actuators B Chem 208:389–398

    Google Scholar 

  336. Li X-R et al (2015) Bimetallic Au@ Pt@ Au core–shell nanoparticles on graphene oxide nanosheets for high-performance H2O2 bi-directional sensing. J Mater Chem B 3(21):4355–4362

    Google Scholar 

  337. Yang Y et al (2015) Highly sensitive hydrogen peroxide sensor based on a glassy carbon electrode modified with platinum nanoparticles on carbon nanofiber heterostructures. Microchim Acta 182(13):2241–2249

    Google Scholar 

  338. Shi L et al (2015) Electrocatalytic sensing of hydrogen peroxide using a screen printed carbon electrode modified with nitrogen-doped graphene nanoribbons. Microchim Acta 182(15):2485–2493

    Google Scholar 

  339. Cui X et al (2015) Sensing hydrogen peroxide using a glassy carbon electrode modified with in situ electrodeposited platinum-gold bimetallic nanoclusters on a graphene surface. Microchim Acta 182(1–2):265–272

    Google Scholar 

  340. Dong S et al (2015) High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells. Anal Chim Acta 853:200–206

    Google Scholar 

  341. Zhang R, Chen W (2015) Fe3C-functionalized 3D nitrogen-doped carbon structures for electrochemical detection of hydrogen peroxide. Sci Bull 60(5):522–531

    Google Scholar 

  342. Ju J, Chen W (2015) In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. Anal Chem 87(3):1903–1910

    Google Scholar 

  343. Vilian ATE et al (2016) Immobilization of hemoglobin on functionalized multi-walled carbon nanotubes-poly-l-histidine-zinc oxide nanocomposites toward the detection of bromate and H2O2. Sens Actuators B Chem 224:607–617

    Google Scholar 

  344. Lou X et al (2016) Cost-effective three-dimensional graphene/Ag aerogel composite for high-performance sensing. Electrochim Acta 205:70–76

    Google Scholar 

  345. Frontera P et al (2016) Characterisation and H2O2 sensing properties of TiO2-CNTs/Pt electro-catalysts. Mater Chem Phys 170:129–137

    Google Scholar 

  346. Chen T-W, Palanisamy S, Chen S-M (2016) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with a composite consisting of chitosan-encapsulated graphite and platinum nanoparticles. Microchim Acta 183(11):2861–2869

    Google Scholar 

  347. Bai Z et al (2016) Non-enzymatic electrochemical biosensor based on Pt NPs/RGO-CS-Fc nano-hybrids for the detection of hydrogen peroxide in living cells. Biosens Bioelectron 82:185–194

    Google Scholar 

  348. Xu W et al (2016) Direct growth of MnOOH nanorod arrays on a carbon cloth for high-performance non-enzymatic hydrogen peroxide sensing. Anal Chim Acta 913:128–136

    Google Scholar 

  349. Noor AM et al (2016) A glassy carbon electrode modified with graphene oxide and silver nanoparticles for amperometric determination of hydrogen peroxide. Microchim Acta 183(2):911–916

    Google Scholar 

  350. Li C et al (2016) A novel nonenzymatic biosensor for evaluation of oxidative stress based on nanocomposites of graphene blended with CuI. Anal Chim Acta 933:66–74

    Google Scholar 

  351. Zhang C et al (2016) Electrochemical sensor based on graphene-supported tin oxide nanoclusters for nonenzymatic detection of hydrogen peroxide. Electrochim Acta 210:181–189

    Google Scholar 

  352. Amanulla B et al (2017) A non-enzymatic amperometric hydrogen peroxide sensor based on iron nanoparticles decorated reduced graphene oxide nanocomposite. J Colloid Interface Sci 487:370–377

    Google Scholar 

  353. Qin Z et al (2017) Core/shell microcapsules consisting of Fe3O4 microparticles coated with nitrogen-doped mesoporous carbon for voltammetric sensing of hydrogen peroxide. Microchim Acta 184(11):4513–4520

    Google Scholar 

  354. N’Diaye J et al (2017) Facile synthesis rhodium nanoparticles decorated single layer graphene as an enhancement hydrogen peroxide sensor. J Electroanal Chem 789:85–91

    Google Scholar 

  355. Zhao C, Zhang H, Zheng J (2017) A non-enzymatic electrochemical hydrogen peroxide sensor based on Ag decorated boehmite nanotubes/reduced graphene oxide nanocomposites. J Electroanal Chem 784:55–61

    Google Scholar 

  356. Yusoff N et al (2017) Ternary nanohybrid of reduced graphene oxide-nafion@silver nanoparticles for boosting the sensor performance in non-enzymatic amperometric detection of hydrogen peroxide. Biosens Bioelectron 87:1020–1028

    Google Scholar 

  357. Liu J-X, Ding S-N (2017) Non-enzymatic amperometric determination of cellular hydrogen peroxide using dendrimer-encapsulated Pt nanoclusters/carbon nanotubes hybrid composites modified glassy carbon electrode. Sens Actuators B Chem 251:200–207

    Google Scholar 

  358. Yuan Y et al (2017) Non-enzymatic amperometric hydrogen peroxide sensor using a glassy carbon electrode modified with gold nanoparticles deposited on CVD-grown graphene. Microchim Acta 184(12):4723–4729

    Google Scholar 

  359. Zhou D et al (2017) Fe3N-Co2N nanowires array: a non-noble-metal bifunctional catalyst electrode for high-performance glucose oxidation and H2O2 reduction toward non-enzymatic sensing applications. Chem Eur J 23(22):5214–5218

    Google Scholar 

  360. Liu W et al (2017) CuS/RGO hybrid by one-pot hydrothermal method for efficient electrochemical sensing of hydrogen peroxide. Chin Chem Lett 28(6):1306–1311

    Google Scholar 

  361. Ravindran Madhura T et al (2017) Nanosheet-like manganese ferrite grown on reduced graphene oxide for non-enzymatic electrochemical sensing of hydrogen peroxide. J Electroanal Chem 792:15–22

    Google Scholar 

  362. Hsu S-Y, Lee C-L (2017) Sonoelectrochemical exfoliation of highly oriented pyrolytic graphite for preparing defective few-layered graphene with promising activity for non-enzymatic H2O2 sensors. Microchim Acta 184(7):2489–2496

    Google Scholar 

  363. Mayuri P, Saravanan N, Senthil Kumar A (2017) A bioinspired copper 2,2-bipyridyl complex immobilized MWCNT modified electrode prepared by a new strategy for elegant electrocatalytic reduction and sensing of hydrogen peroxide. Electrochim Acta 240:522–533

    Google Scholar 

  364. Zhao S et al (2017) Photoelectrochemical determination of hydrogen peroxide using a gold electrode modified with fluorescent gold nanoclusters and graphene oxide. Microchim Acta 184(3):677–686

    Google Scholar 

  365. Cheng C et al (2017) 3D network and 2D paper of reduced graphene oxide/Cu2O composite for electrochemical sensing of hydrogen peroxide. Anal Chem 90(3):1983–1991

    Google Scholar 

  366. Guler M et al (2018) Electrochemical sensing of hydrogen peroxide using Pd@Ag bimetallic nanoparticles decorated functionalized reduced graphene oxide. Electrochim Acta 263:118–126

    Google Scholar 

  367. Yin D et al (2018) A novel enzyme-free glucose and H2O2 sensor based on 3D graphene aerogels decorated with Ni3N nanoparticles. Anal Chim Acta 1038:11–20

    Google Scholar 

  368. Zhang C et al (2018) Small naked Pt nanoparticles confined in mesoporous shell of hollow carbon spheres for high-performance nonenzymatic sensing of H2O2 and glucose. ACS Omega 3(1):96–105

    Google Scholar 

  369. Zhou J et al (2018) Layered assembly of NiMn-layered double hydroxide on graphene oxide for enhanced non-enzymatic sugars and hydrogen peroxide detection. Sens Actuators B Chem 260:408–417

    Google Scholar 

  370. Hassan M et al (2018) Sensitive nonenzymatic detection of hydrogen peroxide at nitrogen-doped graphene supported-CoFe nanoparticles. Talanta 188:339–348

    Google Scholar 

  371. Zhou Y et al (2018) Oriented growth of cross-linked metal-organic framework film on graphene surface for non-enzymatic electrochemical sensor of hydrogen peroxide in disinfectant. Talanta 188:282–287

    Google Scholar 

  372. Lu B et al (2018) Cost-effective three dimensional Ag/polymer dyes/graphene-carbon spheres hybrids for high performance nonenzymatic sensor and its application in living cell H2O2 detection. Bioelectrochemistry 123:103–111

    Google Scholar 

  373. Xu Q et al (2018) Dual nanoenzyme modified microelectrode based on carbon fiber coated with AuPd alloy nanoparticles decorated graphene quantum dots assembly for electrochemical detection in clinic cancer samples. Biosens Bioelectron 107:153–162

    Google Scholar 

  374. Gautam V, Singh KP, Yadav VL (2018) Polyaniline/multiwall carbon nanotubes/starch nanocomposite material and hemoglobin modified carbon paste electrode for hydrogen peroxide and glucose biosensing. Int J Biol Macromol 111:1124–1132

    Google Scholar 

  375. Chou T-C et al (2018) Pt-MWCNT modified carbon electrode strip for rapid and quantitative detection of H2O2 in food. J Food Drug Anal 26(2):662–669

    Google Scholar 

  376. Li J et al (2018) Facile synthesis of Ag@Cu2O heterogeneous nanocrystals decorated N-doped reduced graphene oxide with enhanced electrocatalytic activity for ultrasensitive detection of H2O2. Sens Actuators B Chem 260:529–540

    Google Scholar 

  377. Hou B et al (2018) Preparation of pristine graphene in ethanol assisted by organic salts for nonenzymatic detection of hydrogen peroxide. J Colloid Interface Sci 510:103–110

    Google Scholar 

  378. Liu Z-T et al (2018) A sonoelectrochemical preparation of graphene nanosheets with graphene quantum dots for their use as a hydrogen peroxide sensor. Electrochim Acta 261:530–536

    Google Scholar 

  379. Dai H et al (2018) High-performance electrochemical biosensor for nonenzymatic H2O2 sensing based on Au@C-Co3O4 heterostructures. Biosens Bioelectron 118:36–43

    Google Scholar 

  380. Li H et al (2018) Pt-Pd bimetallic nanocoral modified carbon fiber microelectrode as a sensitive hydrogen peroxide sensor for cellular detection. Sens Actuators B Chem 260:174–182

    Google Scholar 

  381. Liu J et al (2018) Preparation of a nanocomposite material consisting of cuprous oxide, polyaniline and reduced graphene oxide, and its application to the electrochemical determination of hydrogen peroxide. Microchim Acta 185(3):172

    Google Scholar 

  382. Dhara K et al (2018) Fabrication of highly sensitive nonenzymatic electrochemical H2O2 sensor based on Pt nanoparticles anchored reduced graphene oxide. J Nanosci Nanotechnol 18(6):4380–4386

    Google Scholar 

  383. Liu Y et al (2018) Highly sensitive platinum nanoparticles-embedded porous graphene sensor for monitoring ROS from living cells upon oxidative stress. Sens Actuators B Chem 263:543–549

    Google Scholar 

  384. Ning L et al (2018) A highly sensitive nonenzymatic H2O2 sensor based on platinum, ZnFe2O4 functionalized reduced graphene oxide. J Alloys Compd 738:317–322

    Google Scholar 

  385. Fu L et al (2018) A glassy carbon electrode modified with N-doped carbon dots for improved detection of hydrogen peroxide and paracetamol. Microchim Acta 185(2):87

    Google Scholar 

  386. Fu Y et al (2018) Graphene blended with SnO2 and Pd-Pt nanocages for sensitive non-enzymatic electrochemical detection of H2O2 released from living cells. Anal Chim Acta 1014:10–18

    Google Scholar 

  387. Wang M et al (2018) Fabrication of a novel ZnO–CoO/rGO nanocomposite for nonenzymatic detection of glucose and hydrogen peroxide. Ceram Int 44(5):5250–5256

    Google Scholar 

  388. Wu X et al (2018) One-step construction of hierarchical Ni(OH)2/RGO/Cu2O on Cu foil for ultra-sensitive non-enzymatic glucose and hydrogen peroxide detection. Sens Actuators B Chem 274:163–171

    Google Scholar 

  389. Kubendhiran S et al (2018) Electrochemical co-preparation of cobalt sulfide/reduced graphene oxide composite for electrocatalytic activity and determination of H2O2 in biological samples. J Colloid Interface Sci 509:153–162

    Google Scholar 

  390. Lin Y et al (2015) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite made from carbon nanotubes and molybdenum disulfide. Microchim Acta 182(9–10):1803–1809

    Google Scholar 

  391. Mani V et al (2016) MoS2 flowers grown on graphene/carbon nanotubes: a versatile substrate for electrochemical determination of hydrogen peroxide. Int J Electrochem Sci 11:2954–2961

    Google Scholar 

  392. Zhu L et al (2016) PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells. Biosens Bioelectron 80:601–606

    Google Scholar 

  393. Lin X, Ni Y, Kokot S (2016) Electrochemical and bio-sensing platform based on a novel 3D Cu nano-flowers/layered MoS2 composite. Biosens Bioelectron 79:685–692

    Google Scholar 

  394. Li X, Du X (2017) Molybdenum disulfide nanosheets supported Au–Pd bimetallic nanoparticles for non-enzymatic electrochemical sensing of hydrogen peroxide and glucose. Sens Actuators B Chem 239:536–543

    Google Scholar 

  395. Zhou J et al (2017) One-step electrodeposition of Au–Pt bimetallic nanoparticles on MoS2 nanoflowers for hydrogen peroxide enzyme-free electrochemical sensor. Electrochim Acta 250:152–158

    Google Scholar 

  396. Cheng Z et al (2017) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with the layered MoS2-reduced graphene oxide and Prussian Blue. Microchim Acta 184(12):4587–4595

    Google Scholar 

  397. Wang J et al (2017) Enzymeless voltammetric hydrogen peroxide sensor based on the use of PEDOT doped with Prussian Blue nanoparticles. Microchim Acta 184(2):483–489

    Google Scholar 

  398. Xue Y et al (2018) Hierarchical oxygen-implanted MoS2 nanoparticle decorated graphene for the non-enzymatic electrochemical sensing of hydrogen peroxide in alkaline media. Talanta 176:397–405

    Google Scholar 

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Acknowledgements

Keerthy Dhara expresses her sincere thanks to the Department of Science and Technology (DST), India for the financial assistance under the SERB-NPDF scheme (Sanction No: PDF/2016/002383).

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  1. Laboratory for Integrative Multiscale Engineering Materials and Systems, Department of Aerospace Engineering, Indian Institute of Sciences, Bangalore, 560012, India

    Keerthy Dhara & Debiprosad Roy Mahapatra

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Dhara, K., Mahapatra, D.R. Recent advances in electrochemical nonenzymatic hydrogen peroxide sensors based on nanomaterials: a review. J Mater Sci 54, 12319–12357 (2019). https://doi.org/10.1007/s10853-019-03750-y

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