Skip to main content

Advertisement

SpringerLink
Log in

Comparison of antibacterial properties of commercial bone cements and fillers with a zinc-based glass polyalkenoate cement

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Postoperative infection following invasive surgical procedures is a significant cause for concern, particularly in spinal reconstructive surgery. The objective of this study is to compare the antibacterial efficacy of a novel zinc-based glass polyalkenoate cement (Zn-GPC) based on 0.04SrO–0.12CaO–0.36ZnO–0.48SiO2 glass, to a number of commercially available bone cements and fillers including Simplex P + Tobramycin (STob), Spineplex (Spine) and Novabone Putty (NPut). The agar diffusion test was performed on each material against Escherichia coli, Staphlococcus epidermidis, Pseudomonas aeruginosa and Staphlococcus Aureus. STob was found to produce large inhibition zones in each of the bacteria tested and was statistically significantly higher than any other material. The experimental Zn-GPC (BTSC) was found to exhibit antibacterial properties in both E. coli and S. epidermidis. Neither Spine nor NPut showed any inhibitory effect in any of the bacteria tested. A study was also performed to determine the effect of antibiotic release from STob and Zn-GPC (BTob) containing the antibiotic tobramycin (Tob). Antibacterial efficacy was found to increase with respect to maturation with BTob, whereas STob was found to decrease significantly over the time period of 0–14 days. The final objective is to investigate any change in agar composition during the agar-diffusion test. Little change was observed for STob as antibiotic release cannot be determined using EDX. There was, however, an increase in Zn levels when analysing BTSC which suggests that Zn is playing a role in the antimicrobial nature of the Zn-GPC. No significant changes were observed for Spine or NPut.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Subbiahdoss G, Kuijer R, Grijpma DW, Van der Mei HC, Busscher HJ (2009) Acta Biomater 5:1399

    Article  PubMed  Google Scholar 

  2. Diefenbeck M, Muckley T, Hofmann GO (2006) Injury 37:S95

    Article  PubMed  Google Scholar 

  3. An YH, Friedman RJ (1997) J Microbiol Meth 30:141

    Article  Google Scholar 

  4. Dillow AK, Tirrell M (1998) Curr Opin Solid State Mater Sci 3:252

    Article  Google Scholar 

  5. Rafiq I, Gambhir AK, Wroblewski BM, Kay PR (2006) Int Orthop 30:532

    Article  PubMed  Google Scholar 

  6. Squire MW, Ludwig BJ, Thompson JR, Jagodzinski J, Hall D, Andes D (2008) J Arthroplasty 23(1):110

    Article  PubMed  Google Scholar 

  7. Zilberman M, Elsner JJ (2008) J Cont Rel 130:202

    Article  Google Scholar 

  8. Takahashi Y, Imazato S, Kaneshiro AV, Ebisu S, Frencken JE, Tay FR (2006) Dent Mater 22:647

    Article  PubMed  Google Scholar 

  9. Marczuk-Kolada G, Jakoniuk P, Mystkowska J, Luczaj-Cepowicz E, Waszkiel D, Dabrowski JR, Leszczynska K (2006) Postepy Hig Med Dosw 60:416

    Google Scholar 

  10. Seppa L, Forss H, Ogaard B (1993) J Dent Res 72(9):1310

    PubMed  Google Scholar 

  11. Hayacibara MF, Rosa OPS, Koo H, Torres SA, Costa B, Cury JA (2003) J Dent Res 82(4):267

    Article  PubMed  Google Scholar 

  12. Daugela P, Oziunas R, Zekonis G (2008) Stomatol, Baltic Dent Maxillofac J 10:16

    Google Scholar 

  13. Polizzi S, Pira E, Ferrara M, Bugiani M, Papaleo A, Albera R, Palmi S (2002) Neuro Toxicol 23:761

    Google Scholar 

  14. Reusche E, Pilz P, Oberascher G, Linder B, Egensperger R, Gloeckner K, Trinka E, Iglseder B (2001) Human Pathol 32(10):1136

    Article  Google Scholar 

  15. Firling CE, Hill TA, Severson AR (1999) Arch Toxicol 73:359

    Article  PubMed  Google Scholar 

  16. Sawai J (2003) J Microbiol Meth 54:177

    Article  Google Scholar 

  17. Sawai J, Shinobu S, Igarashi H, Hashimoto A, Kokugan T, Shimizu M, Kojima K (1998) J Ferm Bioeng 86(5):521

    Article  Google Scholar 

  18. Shashibhushan KK, Basappa N, Subba Reddy VV (2008) J Indian Soc Pedod Prev Dent 26(2):S56

    PubMed  Google Scholar 

  19. Yamaguchi M, Ma ZJ (2001) Cal Tissue Int 69:158

    Article  Google Scholar 

  20. Yamaguchi M, Ma ZJ (2001) J Bone Miner Metab 19:38

    Article  PubMed  Google Scholar 

  21. Singh B, Lim MR (2007) Oper Tech Orthop 17:199

    Article  Google Scholar 

  22. Mack D, Becker P, Chatterjee I, Dobinsky S, Knobloch JK-M, Peters G, Rohde H, Herrmann M (2004) Int J Med Microbiol 294:203

    Article  PubMed  Google Scholar 

  23. Papagelopoulos PJ, Mavrogenis AF, Giannitsioti E, Kikilas A, Kanellakpooulou K, Soucacos PN (2007) J Arthroplasty 22(3):457

    Article  PubMed  Google Scholar 

  24. Andonian S, Rabah DM, Aprikian AG (2002) Urology 60(4):698

    Article  PubMed  Google Scholar 

  25. Arciola CA, Campoccia D, Gamberini S, Donati ME, Pirini V, Visai L, Speziale P, Montanaro L (2005) Biomaterials 26:6530

    Article  PubMed  Google Scholar 

  26. Heyer CM, Al-Hardi A, Mueller K-M, Stachon A, Nicolas V (2008) Acad Radiol 15:901

    Article  PubMed  Google Scholar 

  27. van den Brand ICJB, Castelein RM (2001) J Arthroplasty 16(7):850

    PubMed  Google Scholar 

  28. Du J, Jasti B, Vasavada RC (1997) J Control Release 43:223

    Article  Google Scholar 

  29. Le Goffic F, Tangy F, Moreau B, Capmau M-L (1979) J Antibiot 32(12):1288

    PubMed  Google Scholar 

  30. Ratjen F, Doring G, Nikolaizik WH (2001) Lancet 358:983

    Article  PubMed  Google Scholar 

  31. Moriarty F, Elborn S, Tunney M (2005) J Microbiol Meth 61:171

    Article  Google Scholar 

  32. D’Arrigo M, Ginestra G, Mandalari G, Furneri PM, Bisignano G (2009) Phytomed. doi:10.1016/j.phymed.2009.07.08 (in press)

  33. Talan DA (2008) Ann Emerg Med 51(3):299

    Article  PubMed  Google Scholar 

  34. Harris LG, Richards RG (2006) Injury 37:S3

    Article  PubMed  Google Scholar 

  35. Rabaud C, Mauuary G (2001) Pathol Biol 49:812

    Article  PubMed  Google Scholar 

  36. Lode H (1998) Curr Ther Res 59(7):420

    Article  Google Scholar 

  37. Weijmer MC, Debets-Ossenkopp YJ, van de Vondervoort FJ, Ter Wee PM (2002) Neph Dial Trans 17:2189

    Article  Google Scholar 

  38. Weijmer MC, Van den Dorpel M, Van de Ven PJG, Ter Wee PM, Van Geelen JACA, Groeneveld JO, Van Jaarsveld BC, Koopmans MG, Le Poole CY, Schrander-van der Meer AM, Siegert CEH, Stas KJF (2004) J Am Soc Neph 16:2769

    Article  Google Scholar 

  39. Boyd D, Clarkin OM, Wren AW, Towler MR (2008) Acta Biomater 4:425

    Article  PubMed  Google Scholar 

  40. Wren AW, Boyd D, Thornton R, Cooney JC, Towler MR (2009) J Biomed Mat Res B: App Biomat 90-B(2):700

    Article  Google Scholar 

  41. Daugela P, Oziunas R, Zekonis G (2008) Stomatol, Baltic Dent Maxillofac J 10:16

    Google Scholar 

  42. Schneiders W, Reinstorf A, Pompe W, Grass R, Biewener A, Holch M, Zwipp H, Rammelt S (2007) Bone 40:1048

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA

    A. W. Wren & M. R. Towler

  2. Materials and Surface Science Institute, University of Limerick, Limerick, Ireland

    N. M. Cummins

Authors
  1. A. W. Wren
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. M. Cummins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. R. Towler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. W. Wren.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wren, A.W., Cummins, N.M. & Towler, M.R. Comparison of antibacterial properties of commercial bone cements and fillers with a zinc-based glass polyalkenoate cement. J Mater Sci 45, 5244–5251 (2010). https://doi.org/10.1007/s10853-010-4566-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-010-4566-5

Keywords

Search

Navigation