Skip to main content

Advertisement

Log in

A review on biodegradable polymeric materials for bone tissue engineering applications

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Biodegradable polymer scaffolds have played a significant role in wide range of tissue engineering application such as bone scaffolds since the last decade. The aim of this article is to provide the comprehensive overview of biocompatible and biodegradable polymer materials and composite materials with their advantages and drawbacks in the application of biomaterial scaffolds, furthermore the properties and degradation criteria of the biomaterials are discussed in this review.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Lin C-Y, Schek RM, Mistry AS, Shi X, Mikos AG, Krebsbach PH, Hollister SJ (2005) Tissue Eng 11(9–10):1589

    Article  PubMed  CAS  Google Scholar 

  2. Isenberg BC, Williams C, Tranquillo RT (2006) Circ Res 98:25

    Article  PubMed  CAS  Google Scholar 

  3. Kim BS, Putnam AJ, Kulik TJ, Mooney DJ (1998) Biotechnol Bioeng 57(1):46

    Article  PubMed  CAS  Google Scholar 

  4. Kalfas LH (2001) Neurosurg Focus 10(4)

  5. Dimar JR, Glassman SD (2007) Curr Opin Orthopaed 18(3):226

    Article  Google Scholar 

  6. Gravel M, Gross T, Vago R, Tabrizian M (2006) Biomaterials 27:1899

    Article  PubMed  CAS  Google Scholar 

  7. Cheung H-Y, Lau K-T, Lu T-P, Hui D (2007) Compos Part B 38:291

    Article  CAS  Google Scholar 

  8. Chapekar MS (2000) J Biomed Mater Res 53:617

    Article  PubMed  CAS  Google Scholar 

  9. Sambrook P (ed) (2001) The musculoskeletal system, Chap 5. Elsevier Health Sciences Publishers, pp 67–84. ISBN: 0443070156, 9780443070150

  10. Callaghan JJ (1997) J Bone Joint Surg (Am) 79:1416

    Google Scholar 

  11. Brekke JH, Toth JM (1999) J Biomed Mater Res 43(4):380

    Article  Google Scholar 

  12. Whang K, Thomas CH, Healy KE (1995) Polymer 36:837

    Article  CAS  Google Scholar 

  13. Oh S, Kang SG, Kim ES, Cho SH, Lee JH (2003) Biomaterials 24:4011

    Article  PubMed  CAS  Google Scholar 

  14. Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R (1993) J Biomed Mater Res 27:183

    Article  PubMed  CAS  Google Scholar 

  15. Mathieu LM, Mueller TL, Bourban P-E, Pioletti DP, Muller R, Manson J-AE (2006) Biomaterials 27:905

    Article  PubMed  CAS  Google Scholar 

  16. Shin KC, Kim BS, Kim JH, Park TG, Nam JD, Lee DS (2005) Polymer 46:3801

    Article  CAS  Google Scholar 

  17. Kim HD, Bae EH, Kwon IC, Pal RR, Nam JD, Lee DS (2004) Biomaterials 25:2319

    Article  PubMed  CAS  Google Scholar 

  18. Yoon JJ, Kim JH, Park TG (2003) Biomaterials 24:2323

    Article  PubMed  CAS  Google Scholar 

  19. Reignier J, Huneault MA (2006) Polymer 47:4703

    Article  CAS  Google Scholar 

  20. Seunarine K, Gadegaard N, Tormen M, Meredith DO, Riehle MO, Wilkinson CDW (2006) Nanomedicine 1(3):281

    Article  PubMed  CAS  Google Scholar 

  21. Ma PX (2003) In: Kroschwitz J (ed) Encyclopedia of polymer science and technology, 3rd edn. Wiley, NJ

    Google Scholar 

  22. Borden M, Attawia M, Khan Y, Laurencin CT (2002) Biomaterials 23(2):551

    Article  PubMed  CAS  Google Scholar 

  23. Chen G, Ushida T, Tateishi T (2002) Macromol Biosci 2:67

    Article  CAS  Google Scholar 

  24. Einhorn TA (2004) J Bone Joint Surg (Am) 86:1350

    Google Scholar 

  25. Hollinger JO, Schmitz JP (1997) Ann NY Acad Sci 831:427

    Article  PubMed  CAS  Google Scholar 

  26. Burg KJL, Porter S, Kellam JF (2000) Biomaterials 21:2347

    Article  PubMed  CAS  Google Scholar 

  27. Mauli Agrawal C, Athanasiou KA (1997) Biomed Mater Res Appl Biomater 38:105

    Article  Google Scholar 

  28. Bergsma JE, de Bruijn WC, Rozema FR, Bos RRM, Boering G (1995) Biomoterids 16:25

    Article  CAS  Google Scholar 

  29. Seal BL, Otero TC, Panitch A (2001) Mater Sci Eng 34(4–5):147

    Google Scholar 

  30. Duda A, Penczek S (2002) In: Steinbüchel A, Doi Y (eds) Biopolymers, vol 3b: Polyesters II – Properties and Chemical Synthesis, Chap 12. Wiley-VCH, Weinheim, pp 371–430

  31. Nair LS, Laurencin CT (2006) Adv Biochem Eng Biotechnol 102:47

    PubMed  CAS  Google Scholar 

  32. Shalaby SW, Johnson RA (1994) In: Shalaby SW (ed) Biomedical polymers: designed to degrade systems. Hanser, New York

    Google Scholar 

  33. Rhim J-W, Mohanty AK, Singh SP, Perry KW (2005) J Appl Polym Sci 101:3736

    Article  CAS  Google Scholar 

  34. Mauli Agrawal C, Ray RB (2001) J Biomed Mater Res 55:141

    Article  Google Scholar 

  35. Middleton JC, Tipton AJ (2000) Biomaterials 21:2335

    Article  PubMed  CAS  Google Scholar 

  36. Athanasiou KA, Niederauer GG, Mauli Agrawal C (1996) Biomoterids 17:93

    Article  CAS  Google Scholar 

  37. Miller RA, Brady JM, Cutright DE (1977) J Biomed Mater Res 11:711

    Article  PubMed  CAS  Google Scholar 

  38. Vert M, Li S, Garreau H, Mauduit J, Boustta M, Schwach G, Engel R, Coudane J (1997) Macromol Mater Eng 247:239

    CAS  Google Scholar 

  39. Peter SJ, Nolley J, Widmer M, Merwin JE, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG (1997) Tissue Eng 41(1):207

    Article  Google Scholar 

  40. Hedberg EL, Shih CK, Lemoine JL et al (2005) Biomaterials 26:3215

    Article  PubMed  CAS  Google Scholar 

  41. Domb AJ, Kost J, Wiseman DM (eds) (1998) Handbook of biodegradable polymers, Chap 5. CRC Press Publishers, pp 87–96. ISBN: 9057021536, 9789057021534

  42. Kai Z, Ying D, Guo-Qiang C (2003) Biochem Eng J 16:115

    Article  CAS  Google Scholar 

  43. Chen G-Q, Wu Q (2005) Biomaterials 26:6565

    Article  PubMed  CAS  Google Scholar 

  44. Holland SJ, Jolly AM, Yasin M, Tighe BJ (1987) Biomaterials 8:289

    Article  PubMed  CAS  Google Scholar 

  45. Young Y, Min B-M, Lee SJ, Lee TS, Park WH (2004) J Appl Polym Sci 95:193

    Google Scholar 

  46. Young Y, Lee SW et al (2005) Polym Degrad Stab 90:441

    Article  CAS  Google Scholar 

  47. Sarazin P, Roy X, Favis BD (2004) Biomaterials 25:5965

    Article  PubMed  CAS  Google Scholar 

  48. Kuo Y-C, Leou S-N (2006) Biotechnol Prog 22:1664

    PubMed  CAS  Google Scholar 

  49. Zhao K, Deng Y, Chen JC, Chen G-Q (2003) Biomaterials 24(6):1041

    Article  PubMed  CAS  Google Scholar 

  50. Yao D, Smith A, Nagarajan P et al (2005) J Biomed Mater 77b:287

    Google Scholar 

  51. Kweona HY, Yoo MK, Park K, Kim TH, Chul H, Lee HC (2003) Biomaterials 24:801

    Article  Google Scholar 

  52. Temenoff JS, Mikos AG (2000) Biomaterials 21:2405

    Article  PubMed  CAS  Google Scholar 

  53. Go¨pferich A, Tessmar J (2002) Adv Drug Deliv Rev 54:911

    Article  Google Scholar 

  54. Ibim SEM, Uhrich KE, Attawia M et al (1998) J Biomed Mater 43:374

    Article  CAS  Google Scholar 

  55. Kumara N, Langer RS, Domb AJ (2002) Adv Drug Deliv Rev 54:889

    Article  Google Scholar 

  56. Lakshmi S, Kattia DS, Laurencin CT (2003) Adv Drug Deliv Rev 55:467

    Article  PubMed  CAS  Google Scholar 

  57. Allcock HR (2006) Curr Opin Solid State Mater Sci 10:231

    Article  CAS  MathSciNet  Google Scholar 

  58. Li M, Mondrinos MJ, Chen X, Gandhi MR, Ko FK, Lelkes PI (2006) J Biomed Mater Res A 79(4):963

    PubMed  Google Scholar 

  59. Pouton CW, Akhtar S (1996) Adv Drug Deliv Rev 18:133

    Article  CAS  Google Scholar 

  60. Muggli DS, Burkoth AK, Anseth KS (1999) Biomed Mater 46:271

    Article  CAS  Google Scholar 

  61. Heller J, Barr J, Ng SY (2002) Adv Drug Deliv Rev 54:1015

    Article  PubMed  CAS  Google Scholar 

  62. Parsons JR (1998) In: Black J, Hastings G (eds) Handbook of biomaterials properties. Chapman & Hall, New York

    Google Scholar 

  63. Ibim SM, Ambrosio AA, Larrier D, Allcock HR, Laurencin CT (1996) J Control Release 40:31

    Article  CAS  Google Scholar 

  64. Laurencin CT, Norman ME, Elgendy HM, El-Amin SF, Allcock HR, Pucher SR, Ambrosio AA (1993) J Biomed Mater 27:963

    Article  CAS  Google Scholar 

  65. Conconi MT, Lora S, Menti AM, Carampin P, Parnigotto PP (2006) Tissue Eng 12:4

    Article  Google Scholar 

  66. Kang H-W, Tabata Y, Ikada Y (1999) Biomaterials 20:1339

    Article  PubMed  CAS  Google Scholar 

  67. Vin F, Teot L, Measume S (2002) J Wound Care 11(9):335

    PubMed  CAS  Google Scholar 

  68. Duan X, McLaughlin C, Griffith M, Sheardown H (2007) Biomaterials 28:78

    Article  PubMed  CAS  Google Scholar 

  69. Ruszczak Z (2003) Adv Drug Deliv Rev 55:1595

    Article  PubMed  CAS  Google Scholar 

  70. Green D, Walsh D, Mann S, Oreffo ROC (2002) Bone 30:PG810

    Article  Google Scholar 

  71. Barbosa MA, Granja PL, Barrias CC, Amaral IF (2005) ITBM-RBM 26:212

    Article  Google Scholar 

  72. Francis Suh J-K, Matthew HWT (2000) Biomaterials 21:2589

    Article  CAS  Google Scholar 

  73. Shi C, Zhu Y, Ran X et al (2006) J Surg Res 133:185

    Article  PubMed  CAS  Google Scholar 

  74. Maqueta V, Boccaccini AR et al (2004) Biomaterials 25:4185

    Article  CAS  Google Scholar 

  75. Wei G, Ma PX (2004) Biomaterials 25:4749

    Article  PubMed  CAS  Google Scholar 

  76. Ramakrishna S, Mayer J, Wintermantel E, Leong KW (2001) Compos Sci Technol 61:1189

    Article  CAS  Google Scholar 

  77. Cai Q, Yang J, Bei J, Wang S (2002) Biomaterials 23:4483

    Article  PubMed  CAS  Google Scholar 

  78. Ciardelli G, Chiono V, Vozzi G, Pracella M et al (2005) Biomacromolecules 6:1961

    Article  PubMed  CAS  Google Scholar 

  79. Broz ME, VanderHart DL, Washburn NR (2003) Biomaterials 24:4181

    Article  PubMed  CAS  Google Scholar 

  80. Kim JY, Cho D-W (2009) Microelectron Eng 86:1447

    Article  CAS  Google Scholar 

  81. Nukavarapu SP, Kumbar SG, Brown JL et al (2008) Biomacromolecules 9(7):1818

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Li Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sabir, M.I., Xu, X. & Li, L. A review on biodegradable polymeric materials for bone tissue engineering applications. J Mater Sci 44, 5713–5724 (2009). https://doi.org/10.1007/s10853-009-3770-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-009-3770-7

Keywords

Navigation