Abstract
The present paper discusses different processing technologies for fabrication of novel 45S5 Bioglass®-derived glass–ceramic scaffolds with tailored porosity gradient for potential application in bone tissue engineering. Different types of scaffolds with continuous or stepwise gradient of porosity were produced by the foam replication technique, using preformed polyurethane (PU) foams as sacrificial templates. After preforming the PU foams in metallic moulds, they were dipped in a 45S5 Bioglass®-based slurry and subsequently heat treated in a chamber furnace up to 1100 °C. During heating, the organic phase is burned out and the glass sinters and partially crystallises. By using this new approach, Bioglass®-derived glass-ceramic scaffolds with different shapes and porosity profiles were designed. Scanning electron microscopy (SEM) showed that all samples have highly interconnected porous structure, with specific porosity gradients. By modifying the shape and dimensions of the metallic mould, bioactive glass–ceramic scaffolds with complex shapes and different degrees of porosity gradient could be obtained.
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Martin I, Miot S, Barbero A, Jakob M, Wendt D (2007) J Biomech 40(4):750
Roether JA, Boccaccini AR, Hench LL, Maquet V, Gautier S, Jérôme R (2002) Biomaterials 23:3871
Karageorgiou V, Kaplan D (2005) Biomaterials 26(27):5474
Logeart-Avramoglou D, Anagnostou F, Bizios R et al (2005) J Cell Mol Med 9(1):72
Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biomaterials 27:3413
Pompe W, Worch H, Epple M et al (2003) Mater Sci Eng A362:40
Suresh S, Mortensen A (1998) Fundamentals of functionally graded materials: processing and thermomechanical behaviour of graded metals and metal-ceramic composites. The University Press, Cambridge
Harley BA et al (2006) Biomaterials 27:866
Ghosh S, Viana JC, Reis RL et al (2006) Key Eng Mater 309–311:1109
Sherwood JK, Riley SL, Palazzolo R et al (2002) Biomaterials 23:4739
Oliveira JM, Rodrigues MT, Silva SS et al (2006) Biomaterials 27:6123
Hench LL (1998) J Am Ceram Soc 81:1705
Chichoki FR, Trumble KP (1998) J Am Ceram Soc 81:1661
Chung TJ, Neubrand A, Roedel J (2002) Key Eng Mater 206–213:965
Chen QZ, Thompson ID, Boccaccini AR (2006) Biomaterials 27:2414
Acknowledgements
This work was funded with support of the EU Marie Curie fellowship scheme (Grant MEIF-CT-2005-024248).
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Bretcanu, O., Samaille, C. & Boccaccini, A.R. Simple methods to fabricate Bioglass®-derived glass–ceramic scaffolds exhibiting porosity gradient. J Mater Sci 43, 4127–4134 (2008). https://doi.org/10.1007/s10853-008-2536-y
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DOI: https://doi.org/10.1007/s10853-008-2536-y