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Implantable photonic crystal for reflection-based optical sensing of biodegradation

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Abstract

Biodegradable inverse opal (IoPPC) was synthesized from a multifunctional carboxylic acid and polyols by colloidal crystal templating. The IoPPC was prepared by infiltration of the monomer solution into interparticle voids of silica colloidal crystal template, polycondensation of the infiltrated film, and removal of the template. The synthesized IoPPC was characterized by infrared absorption, X-ray diffraction measurements, differential scanning calorimetry, and thermogravimetry/mass spectrometry analysis. In order to clarify the effect of biodegradation on the inverse opal structure and the optical reflection property, the IoPPC was implanted in subcutaneous tissue of the lower back of three mice (ICR, 10 weeks, female). After the 2 weeks implantation, fragmented samples were harvested from the implant location and investigated by scanning electron microscope observations and optical reflection measurements. It was found that the reflection peak for the harvested samples decayed from that for the sample without implantation. Such a spectral change is considered to be attributed to the deterioration of the regularity of the inverse opal structures through biodegradation. The finding of this study will serve in the development of reflection-based sensing in various biomedical applications.

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Notes

  1. The refractive index of silica colloids was estimated to be 1.29 from Eq. 3 with a λ max value of 597 nm (Fig. 7b). Such a small refractive index as compared with the value of crystalline silicon dioxide (1.45) is derived from the mesoporous structure of the silica colloids.

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Acknowledgements

The authors thank H. Kitagawa of Kyushu University for XRD measurements and TG/MS analyses. We also acknowledge R. Moriyama of Kinki University for technical instruction in the animal experiments. This work was partly supported by a grant-in-aid for Scientific Research (No. 18500369) from the Ministry of Education, Culture, Sports, Science and Technology, and by the Circle for the Promotion of Science and Engineering.

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Authors and Affiliations

  1. School of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502, Japan

    Musashi Fujishima, Syoei Sakata, Takuya Iwasaki & Kumao Uchida

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  1. Musashi Fujishima
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  2. Syoei Sakata
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  3. Takuya Iwasaki
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  4. Kumao Uchida
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Corresponding author

Correspondence to Musashi Fujishima.

Additional information

The in vivo degradation experiment was approved by the committee on animal experiments of School of Science and Engineering, Kinki University.

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Fujishima, M., Sakata, S., Iwasaki, T. et al. Implantable photonic crystal for reflection-based optical sensing of biodegradation. J Mater Sci 43, 1890–1896 (2008). https://doi.org/10.1007/s10853-007-2419-7

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  • DOI: https://doi.org/10.1007/s10853-007-2419-7

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