Abstract
Aqueous-solution complexes of β-cyclodextrin (β-CD) with metoprolol tartrate (MET) have been analysed with 1H NMR and UV–vis spectroscopy. With 1H NMR a [1:1] stoichiometry could be established for the β-CD-MET complex while its stability constant was determined with UV–vis spectroscopy. Powder diffraction data of a polycrystalline sample of the β-CD-MET complex show that a novel product has been formed, likely to be a β-CD-MET [1:1] inclusion complex. Also Hyperchem MM+ molecular-dynamics results suggest an inclusion complex and from 1H NMR data it is inferred that probably the MET is docked in the CD with the formers methoxyethyl-benzene moiety in front.
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Acknowledgments
The authors acknowledge the ESRF (Grenoble, France) for the opportunity to perform the synchrotron diffraction experiments and Dr. H. Emerich for his help at beamline BM01B (Swiss-Norwegian CRG). They also thank Dr. M.M. Pop, Dr. V. Brodski and Dr. D.J.A. De Ridder for their assistance in collecting the data. One of the authors (Borodi) is indebted to the Netherlands Foundation for Scientific research (NWO) for financial support (NB 71-135) to carry out part of the research in Amsterdam. The spectroscopic investigations and molecular modelling were supported by the CEEX no7/2005 VIASAN project. Thanks are due also to Dr. L. Copolovici from the Faculty of Chemistry, “Babes-Bolyai” University for his assistance in the determination of the association constant from the optical spectra.
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Mihaela Toma is Socrates/Erasmus student at UNED Madrid
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Dragan, F., Bratu, I., Borodi, G. et al. Spectroscopic investigation of β-cyclodextrin -metoprolol tartrate inclusion complexes. J Incl Phenom Macrocycl Chem 59, 125–130 (2007). https://doi.org/10.1007/s10847-007-9304-5
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DOI: https://doi.org/10.1007/s10847-007-9304-5