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The hemodynamic pattern of the syndrome of delayed orthostatic hypotension

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Purpose

We investigated the hemodynamic mechanisms underlying the syndrome of delayed orthostatic hypotension (OH) and the hemodynamic effect of the treatment with leg compression bandages.

Methods

Non-invasive monitoring of systolic blood pressure (SBP), heart rate (HR), cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) was performed during tilt testing in patients affected by delayed OH compared to age- and sex-matched controls. Thirteen patients (68 ± 14 years) and nine controls (68 ± 8 years) were studied.

Results

Immediately after tilt-up, SBP progressively decreased in patients but not in controls. Symptoms developed at 100 ± 7 mmHg. At the end of the test, SBP was significantly lower in patients than in controls. TPR progressively decreased in patients but not in controls. SV and CO did not change significantly. HR increased progressively in the patients until the end of the test and remained unchanged in controls. Active treatment with compression bandages avoided the decrease in SBP and TPR, while CO showed minimal variation.

Conclusion

In patients affected by delayed OH, the progressive decrease of SBP is associated with progressive decrease of TPR, while CO and SV show little variation; the compensatory increase in HR is insufficient to compensate for the decline in blood pressure.

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Acknowledgments

Cristian Podoleanu, Emilian Carasca, and Carmen Ginghina were supported by the National University Research Council of Romania (grant CNCSIS 1125/2007).

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Authors and Affiliations

  1. Cardiology Department, 4th Medical Clinic, University of Medicine and Pharmacy Targu Mures, Str. Gh. Marinescu 1, 540099, Targu Mures, Romania

    Cristian Podoleanu & Emilian Carasca

  2. Arrhythmologic Centre, Cardiology Department, Ospedali del Tigullio, Lavagna (GE), 16033, Italy

    Roberto Maggi, Daniele Oddone, Alberto Solano, Paolo Donateo, Francesco Croci & Michele Brignole

  3. CC Iliescu Heart Institute, University of Medicine and Pharmacy Bucharest, Sos. Fundeni nr. 258, sector 2, Bucharest, Romania

    Carmen Ginghina

  4. Str. Ulciorului nr. 1, 540099, Targu Mures, Romania

    Cristian Podoleanu

Authors
  1. Cristian Podoleanu
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  2. Roberto Maggi
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  3. Daniele Oddone
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  4. Alberto Solano
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  5. Paolo Donateo
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  6. Francesco Croci
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  7. Emilian Carasca
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  8. Carmen Ginghina
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  9. Michele Brignole
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Corresponding author

Correspondence to Cristian Podoleanu.

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Podoleanu, C., Maggi, R., Oddone, D. et al. The hemodynamic pattern of the syndrome of delayed orthostatic hypotension. J Interv Card Electrophysiol 26, 143–149 (2009). https://doi.org/10.1007/s10840-009-9429-0

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  • DOI: https://doi.org/10.1007/s10840-009-9429-0

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