Skip to main content
SpringerLink
Log in

Ovulation and birth after administration of progesterone trigger—two case reports

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To determine whether using progesterone as a trigger of a gonadotropin surge will induce ovulation and a competent corpus luteum.

Methods

Patients were administered 5 or 10 mg of progesterone intramuscularly when the leading follicle reached preovulatory size.

Results

We demonstrate that progesterone injections result in classical ultrasonographic hallmarks of ovulation about 48 h later and the formation of a corpus luteum competent to support pregnancy.

Conclusion

Our results support further exploration of using progesterone to trigger a gonadotropin surge in assisted human reproduction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Leyendecker G, Wardlaw S, Nocke W. Experimental studies on the endocrine regulations during the periovulatory phase of the human menstrual cycle. The effects of exogenous 17 -oestradiol and progesterone on the release of pituitary luteinizing and follicle stimulating hormones. Acta Endocrinol (Copenh). 1972;71(1):160–78.

    CAS  PubMed  Google Scholar 

  2. Sharma B, Koysombat K, Comninos AN, Dhillo WS, Abbara A. Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment. Front Endocrinol (Lausanne). 2022;13:972137.

    Article  PubMed  Google Scholar 

  3. Wartosch L, Schindler K, Schuh M, et al. Origins and mechanisms leading to aneuploidy in human eggs. Prenat Diagn. 2021;41(5):620–30. https://doi.org/10.1002/pd.5927.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Dozortsev DI, Diamond MP. Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Fertil Steril. 2020;114(2):191–9. https://doi.org/10.1016/j.fertnstert.2020.06.016.

    Article  CAS  PubMed  Google Scholar 

  5. Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983;57(4):792–6.

    Article  CAS  PubMed  Google Scholar 

  6. Dozortsev D, Pellicer A, Diamond MP. Progesterone is a physiological trigger of ovulatory gonadotropins. Fertil Steril. 2020;113(5):923–4. https://doi.org/10.1016/j.fertnstert.2019.12.024.

    Article  PubMed  Google Scholar 

  7. Rothchild I. Interrelations between progesterone and the ovary, pituitary, and central nervous system in the control of ovulation and the regulation of progesterone secretion. Vitam Horm. 1965;23:210–327.

    CAS  PubMed  Google Scholar 

  8. Odell WD, Swerdloff RS. Progestogen-induced luteinizing and follicle-stimulating hormone surge in postmenopausal women: a simulated ovulatory peak. PNAS. 1968;61(2):529–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liu JH, Yen SS. Induction of midcycle gonadotropin surge by ovarian steroids in women: a critical evaluation. J Clin Endocrinol Metab. 1983;57(4):797–802.

    Article  CAS  PubMed  Google Scholar 

  10. Zalányi S. Progesterone and ovulation. Eur J Obstet Gynecol Reprod Biol. 2001;98(2):152–9.

    Article  PubMed  Google Scholar 

  11. Nillius SJ, Johansson ED. Plasma levels of progesterone after vaginal, rectal, or intramuscular administration of progesterone. Am J Obstet Gynecol. 1971;110(4):470–7.

    Article  CAS  PubMed  Google Scholar 

  12. Rijken-Zijlstra TM, Haadsma ML, Hammer C, Burgerhof JG, Pelinck MJ, Simons AH, van Echten-Arends J, Arts JG, Land JA, Groen H, Hoek A. Effectiveness of indomethacin to prevent ovulation in modified natural-cycle IVF: a randomized controlled trial. Reprod Biomed Online. 2013;27(3):297–304.

    Article  CAS  PubMed  Google Scholar 

  13. Hurst BS, Merriam KS, Elliot M, Matthews ML, Marshburn PB, Usadi RS, Hurst BS. A sustained elevated estradiol is not the trigger for the preovulatory luteinizing hormone surge. Women’s Health Gynecol. 2015;1:1–3.

    Google Scholar 

  14. Dozortsev DI, Pellicer A, Diamond MP. Premature progesterone rise as a trigger of polycystic ovarian syndrome. Fertil Steril. 2020;114(5):943–4. https://doi.org/10.1016/j.fertnstert.2020.07.007.

    Article  CAS  PubMed  Google Scholar 

  15. Dozortsev DI, Diamond MP. Two peas from the same pod: vanishing follicles and postmature oocytes. Fertil Steril. 2022;117(1):40–1. https://doi.org/10.1016/j.fertnstert.2021.09.027.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CITMER Medicina Reproductiva, Mexico City, Mexico

    Lina Villar, Israel Maldonado & Dmitri I. Dozortsev

  2. Advanced Fertility Center of Texas, Houston, TX, USA

    Beata Tralik, Michael Allon & Dmitri I. Dozortsev

  3. Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Michael P. Diamond

Authors
  1. Lina Villar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beata Tralik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael P. Diamond
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Allon
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Israel Maldonado
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dmitri I. Dozortsev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dmitri I. Dozortsev.

Ethics declarations

Conflict of interest

Dr. Diamond and Dr. Dozortsev have pending patent for progesterone repurposing for triggering ovulation.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Villar, L., Tralik, B., Diamond, M.P. et al. Ovulation and birth after administration of progesterone trigger—two case reports. J Assist Reprod Genet 40, 1037–1044 (2023). https://doi.org/10.1007/s10815-023-02750-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-023-02750-x

Keywords

Search

Navigation