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BRCA, infertility, and fertility preservation: a review for counseling

  • Fertility Preservation
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Abstract

BRCA mutations as a triggering factor in breast cancer have been reported to result in fertility problems and oocyte aging in young patients with cancer diagnosis. These patients are concerned about fertility problems and family planning before undergoing treatment modalities that may result in infertility. In this review, we conducted analysis of the literature on the association between BRCA mutations and infertility, possible fertility preservation options, and their safety and tried to gather results from different disciplines and points of view on the matter. Our aim is to provide a general summary of recent studies to provide further insight on the matter for counseling BRCA mutation carriers on fertility preservation methods and their implications.

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Abbreviations

BRCA:

BReast CAncer gene

DNA:

Deoxyribonucleic acid

DSB:

Double-strand break

MRE:

Meiotic recombination 11 homolog A

RAD50/51:

Radiation50/51

NSB1:

Nijmegen breakage syndrome 1

ATM:

Ataxia telangiectasia mutated

ATR:

Ataxia telangiectasia and Rad3 related

ɣH2AX:

H2A histone family member X

MDC1:

Mediator of DNA damage checkpoint 1

CHK2:

Checkpoint kinase 2

53BP1:

Tumor suppressor p53-binding protein 1

DMC1:

DNA meiotic recombinase 1

AMH:

Anti-Müllerian hormone

HR:

Homologous recombination

NHEJ:

Non-homologous end joining

ART:

Assisted reproductive techniques

FP:

Fertility preservation

IVF:

In vitro fertilization

PGD:

Pre-implantation genetic diagnosis

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Authors and Affiliations

  1. Department of Medical Genetics, Başkent University Hospital, Ankara, Turkey

    Ege Baltacı & Feride İffet Şahin

  2. Department of Gynecology and Obstetrics, Nezip Fazıl City Hospital, Kahramanmaraş, Turkey

    Ferah Kazancı

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  1. Ege Baltacı
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Baltacı, E., Kazancı, F. & Şahin, F.İ. BRCA, infertility, and fertility preservation: a review for counseling. J Assist Reprod Genet 40, 465–472 (2023). https://doi.org/10.1007/s10815-023-02725-y

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