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Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-thawed embryo transfer (FET): analysis of 4148 cycles reported to SART CORS

  • Assisted Reproduction Technologies
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Abstract

Purpose

To investigate whether live birth rates from euploid blastocyst frozen-thawed embryo transfer (FET) cycles are associated with infertility diagnosis or oocyte source.

Design

Retrospective analysis of FET cycles reported to SART CORS in 2014.

Methods

Data from fresh IVF cycles with preimplantation genetic testing for aneuploidy (PGT-A), linked to the first FET cycles, were collected from the 2014 SART CORS database for autologous and donor oocyte cycles. Inclusion criteria were patients undergoing FET with euploid embryos (n = 4148). Demographic data including age, BMI, prior fertility, and etiology of infertility were collected from the retrieval cycle and analyzed. Patients with uterine anomalies, preimplantation genetic testing-mutation (PGT-M) for genetic diseases, gender selection, HLA determination, or systemic and immunologic disorders were excluded. The primary outcome measure was live birth (LB) rate. Potential confounders such as age, prior fertility, and maximum baseline FSH values were analyzed with regression models as indicated.

Results

Though age, maximum baseline FSH, and infertility diagnosis were significantly different, LB was similar between patients undergoing autologous or donor oocyte FET cycles. Etiology of infertility was not significantly associated with LB in autologous cycles (p = 0.95). Potential confounders such as maternal age, prior fertility, and maximum baseline FSH were not associated with outcomes; however, maternal BMI was inversely related to LB in autologous cycles, with an odds ratio of 0.97 (95% CI: 0.96–0.98 (rho = − 0.08, p < 0.01)).

Conclusions

After controlling for confounding variables, a euploid embryo derived from a donor or autologous oocyte results in similar LB in women with different infertility diagnoses.

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Data availability

SART CORS database available with application to SART.

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Acknowledgments

SART wishes to thank all of its members for providing clinical information to the SART CORS database for use by patients and researchers. Without the efforts of our members, this research would not have been possible.

Author information

Author notes

  1. E. Buyuk

    Present address: Reproductive Medicine Associates of New York, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Authors and Affiliations

  1. OC Fertility Center, Newport Beach, CA, 92604, USA

    F. Meng

  2. Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY, USA

    M. Goldsammler, E. Buyuk & S. K. Jindal

  3. Montefiore’s Institute for Reproductive Medicine and Health, 141 S. Central Ave, Hartsdale, NY, 10530, USA

    M. Goldsammler & S. K. Jindal

  4. Redshift Technologies, New York, NY, USA

    E. Wantman

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Contributions

FM, SJ, EW, and EB contributed to the study conception and design. EW assisted with data acquisition and material preparation. FM, MG, EB, and SJ performed data analysis, interpretation, and writing of the manuscript. All authors edited and approved the final manuscript.

Corresponding author

Correspondence to M. Goldsammler.

Ethics declarations

This study was approved by the institutional review board of Albert Einstein College of Medicine.

Conflict of interest

FM, MG, EB, and SJ with nothing to disclose. EW employed by Redshift technologies, the data vendor for SART.

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F. Meng and M. Goldsammler share first authorship equally.

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Meng, F., Goldsammler, M., Wantman, E. et al. Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-thawed embryo transfer (FET): analysis of 4148 cycles reported to SART CORS. J Assist Reprod Genet 38, 185–192 (2021). https://doi.org/10.1007/s10815-020-01996-z

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  • DOI: https://doi.org/10.1007/s10815-020-01996-z

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