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Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3).

Method

Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group.

Results

All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (p < 0.001) suggesting a role for PAI-1 mutation in RM and IF.

Conclusions

The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.

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Acknowledgments

The authors are grateful to the women who kindly accepted to enter this study. We also appreciate the staff of Avicenna Infertility Clinic for their assistance in sample collection and performing the experiments.

Funding

This work was supported by a grant (89-05) from Avicenna Research Institute, Tehran, Iran.

Author information

Authors and Affiliations

  1. Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, P.O. Box.19615-1177, Tehran, Iran

    Farhad Khosravi, Saeed Zarei, Negah Ahmadvand, Mohammad-Reza Sadeghi & Mahmood Jeddi-Tehrani

  2. Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran

    Zahra Akbarzadeh-Pasha & Elham Savadi

  3. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    Amir-Hassan Zarnani

  4. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    Amir-Hassan Zarnani

  5. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    Mohammad-Reza Sadeghi

Authors
  1. Farhad Khosravi
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  2. Saeed Zarei
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  3. Negah Ahmadvand
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  4. Zahra Akbarzadeh-Pasha
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  5. Elham Savadi
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  6. Amir-Hassan Zarnani
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  7. Mohammad-Reza Sadeghi
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  8. Mahmood Jeddi-Tehrani
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Corresponding author

Correspondence to Mahmood Jeddi-Tehrani.

Additional information

Capsule The mutant (4G) allele of plasminogen activator inhibitor type 1 (PAI-1) is significantly increased in women with recurrent miscarriage (RM) and those with implantation failure (IF) compared to control women, suggesting a role for PAI-1 mutation in RM and IF.

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Khosravi, F., Zarei, S., Ahmadvand, N. et al. Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure. J Assist Reprod Genet 31, 121–124 (2014). https://doi.org/10.1007/s10815-013-0125-8

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  • DOI: https://doi.org/10.1007/s10815-013-0125-8

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