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Does premature luteinization or early surge of LH impair cycle outcome? Report of two successful outcomes

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Abstract

Purpose

To report two successful antagonist IVF cycles; one ending up with pregnancy despite premature luteinization (case 1, aged 35 years), and the other with the retrieval of high quality oocytes despite premature ovulation (case 2, aged 39 years).

Methods

Serum LH was 36 and 47 IU/L on cycle day 7 before antagonist administration, which was then brought to 6.94 and 3.92 IU/L by antagonist administration, and kept below these levels throughout the remaining stimulation in case 1 and 2 respectively. Serum progesterone was 1.42 and 5.5 ng/mL on the day of hCG respectively. Ten metaphase II (MII) oocytes were harvested wherein 3 grade A embryos were transferred in case 1, and seven good quality MII oocytes were retrieved wherein six embryos were cryopreserved in case 2.

Conclusions

More precise cut thresholds for both LH and progesterone are necessary for accurate prediction of the cycle outcomes.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, IVF Unit, Ankara University School of Medicine, Ankara University Center for Research on Human Reproduction (USAUM), Ankara, Turkey

    Murat Sönmezer, Cem Atabekoğlu, Sinan Özkavukçu & Batuhan Özmen

  2. Department of Obstetrics and Gynecology, Kırıkkale University School of Medicine, Kırıkkale, Turkey

    Aylin Pelin Cil

  3. Ankara Universitesi Tip Fakultesi Kadin Hast. Dog. AD, 06100 Cebeci, Ankara, Turkey

    Murat Sönmezer

Authors
  1. Murat Sönmezer
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  2. Aylin Pelin Cil
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  3. Cem Atabekoğlu
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  4. Sinan Özkavukçu
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  5. Batuhan Özmen
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Corresponding author

Correspondence to Murat Sönmezer.

Additional information

Capsule Management of premature luteinization in controlled hyperstimulation with GnRH antagonist, regarding the decision to cancel the cycle, is still controversial.

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Sönmezer, M., Pelin Cil, A., Atabekoğlu, C. et al. Does premature luteinization or early surge of LH impair cycle outcome? Report of two successful outcomes. J Assist Reprod Genet 26, 159–163 (2009). https://doi.org/10.1007/s10815-009-9299-5

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  • DOI: https://doi.org/10.1007/s10815-009-9299-5

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