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SERS Substrates for Ultrasensitive Detection of Malachite Green Using Silver Nanostars

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Journal of Applied Spectroscopy Aims and scope

Food additives, crucial for enhancing food quality, have raised concerns regarding their potential carcinogenicity, particularly in substances like malachite green (MG), previously removed from the United States Food and Drug Administration approved list due to identified cancer risks. This investigation delves into the nuanced domain of trace detection employing surface-enhanced Raman spectroscopy (SERS), leveraging the localized plasmon of silver nanoparticle substrates. The research involves a comprehensive comparison between solid- and liquid-based SERS substrates. It utilizes diverse morphologies of silver nanostars (AgNSs) for sensitively detecting MG, substances of considerable interest in the food industry despite their acknowledged carcinogenic properties. A comprehensive characterization of diverse AgNS shapes, including TEM analysis and UV-Vis spectra, reveals distinct plasmon resonance peaks influenced by morphology and the surrounding medium. Finite-difference time-domain (FDTD) simulations underscore the influence of core size and arm number on local electric fields, generating robust hot spots along the edges. The surrounding medium also significantly influenced electric field intensity. SERS examinations reveal liquid-based substrates outperforming their solid counterparts, achieving a remarkable limit of detection (LOD) of 37 aM for MG. These findings were extensively examined in light of their consistency with FDTD simulations and the noticeable variations in enhancement factors observed among different configurations of solid substrates. Simultaneously, the study explores the high reproducibility of liquid-based substrates and endeavors to improve the poor reproducibility of the Raman signal by modifying the surface of solid-based substrates.

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References

  1. N. M. Basti de, F. H. Pierre, and D. E. Corpet, Cancer Prev. Res., 4, 177–184 (2011).

  2. F. Belpoggi , M. Soffritti, E. Tibaldi, L. Falcioni, L. Bua, and F. Trabucco, Ann. New York Acad. Sci., 1076, 736–752 (2006).

    Article  ADS  Google Scholar 

  3. P. Pressman , R. Clemens, W. Hayes, and C. Reddy, Toxic. Res. Appl., 1, 1–22 (2017).

    Google Scholar 

  4. F. Gultekin , S. Yasar, N. Gurbuz, and B. M. Ceyhan, J. Nutr. Health Food Sci., 3, 1–6 (2015).

    Article  Google Scholar 

  5. Y.-L. Chu, D. Chimeddulam, L.-Y. Sheen, and K.-Y. Wu, Food Chem. Toxic., 62, 770–776 (2013).

    Article  Google Scholar 

  6. J. Jiang, Q . Shen, P. Xue, H. Qi, Y. Wu, Y. Teng, Y. Zhang, Y. Liu, X. Zhao, and X. Liu, Chem. Select., 5, 354–359 (2020).

    Google Scholar 

  7. M. Heleyel and S. Elhami, J. Sci. Food Agric., 99, 1919–1925 (2019).

    Article  Google Scholar 

  8. P. Kumar, R . Khosla, M. Soni, D. Deva, and S. K. Sharma, Sens. Actuators, B, 246, 477–486 (2017).

  9. T. T. K. Ch i, N. T. Le, B. T. T. Hien, D. Q. Trung, and N. Q. Liem, Commun. Phys., 26, 261–268 (2016).

  10. T. Y. Jeon , D. J. Kim, S.-G. Park, S.-H. Kim, and D.-H. Kim, Nano Convergence, 3, 1–20 (2016).

    Article  Google Scholar 

  11. R. Aroca, R. Alvarez-Puebla, N. Pieczonka, S. Sanchez-Cortez, and J. Garcia-Ramos, Adv. Colloid Interface Sci., 116, 45–61 (2005).

    Article  Google Scholar 

  12. J.-E. Park , Y. Jung, M. Kim, and J.-M. Nam, ACS Central Sci., 4, 1303–1314 (2018).

    Article  Google Scholar 

  13. P. A. Mosi er-Boss, Nanomaterials, 7, 142 (2017).

  14. X. Zou, H. Zhang, T. Chen, H. Li, C. Meng, Y. Xia, and J. Guo, Colloids Surf. A Physicochem. Eng. Asp., 567, 184–192 (2019).

    Article  Google Scholar 

  15. A. Verma a nd R. Soni, J. Phys. D: Appl. Phys., 54, Article ID 475107 (2021).

  16. H. Zhou, X . Li, L. Wang, Y. Liang, A. Jialading, Z. Wang, and J. Zhang, Rev. Anal. Chem., 40, 173–186 (2021).

    Article  Google Scholar 

  17. Y. Liu, Z. Lu, X. Lin, H. Zhu, W. Hasi, M. Zhang, X. Zhao, and X. Lou, RSC Adv., 6, 58387–58393 (2016).

    Article  ADS  Google Scholar 

  18. P. A. Merc adal, E. R. Encina, and E. A. Coronado, J. Phys. Chem. C, 123, 23577–23585 (2019).

  19. A. C. McGi nnis, B. S. Cummings, and M. G. Bartlett, Analyt. Chim. Acta, 799, 57–67 (2013).

  20. X. Xu, L. Zhao, Q. Xue, J. Fan, Q. Hu, C. Tang, H. Shi, B. Hu, and J. Tian, Anal. Chem., 91, 7973–7979 (2019).

    Article  Google Scholar 

  21. M.-T. Liu, L.-X. Chen, D.-N. Li, A.-J. Wang, Q.-L. Zhang, and J.-J. Feng, J. Colloid Interface Sci., 508, 551–558 (2017).

    Article  ADS  Google Scholar 

  22. B. Kann, H. L. Offerhaus, M. Windbergs, and C. Otto, Adv. Drug Delivery Rev., 89, 71–90 (2015).

    Article  Google Scholar 

  23. S. Schlück er, Angew. Chem., Int. Ed., 53, 4756–4795 (2014).

  24. M. P. Leter tre, P. Giraudeau, and P. De Tullio, Front. Mol. Biosci., 8, 698337 (2021).

  25. A. Garcia-L eis, J. V. Garcia-Ramos, and S. Sanchez-Cortes, J. Phys. Chem. C, 117, 7791–7795 (2013).

  26. K. M. Mayer and J. H. Hafner, Chem. Rev., 111, 3828–3857 (2011).

    Article  Google Scholar 

  27. S. Kaabipou r and S. Hemmati, Beilstein J. Nanotechnol., 12, 102–136 (2021).

  28. Y. Wang, P. H. Camargo, S. E. Skrabalak, H. Gu, and Y. Xia, Langmuir, 24, 12042–12046 (2008).

    Article  Google Scholar 

  29. D. Mulder, M. M. Phiri, and B. C. Vorster, Sens. Bio-Sens. Res., 25, Article ID 100296 (2019).

  30. P. Das, A. Kedia, P. S. Kumar, N. Large, and T. K. Chini, Nanotechnology, 24, 405704 (2013).

    Article  Google Scholar 

  31. W. Ma, H. Y ang, J. Hilton, Q. Lin, J. Liu, L. Huang, and J. Yao, Opt. Express, 18, 843–853 (2010).

  32. K.-Y. Ju, M. C. Fischer, and W. S. Warren, ACS Nano, 12, 12050–12061 (2018).

    Article  Google Scholar 

  33. C.-Y. Huang and C.-H. Chien, Appl. Sci., 9, 5237 (2019).

    Article  Google Scholar 

  34. D. Guzatov, S. Gaponenko, and H. Demir, Z. Phys. Chem., 232, 1431–1441 (2018).

    Google Scholar 

  35. H. de Puig, J. O. Tam, C.-W. Yen, L. Gehrke, and K. Hamad-Schifferli, J. Phys. Chem. C, 119, 17408–17415 (2015).

    Article  Google Scholar 

  36. M. Šubr, M. Petr, O. Kylián, J. Štěpánek, M. Veis, and M. Procházka, Sci. Rep., 7, 4293 (2017).

    Article  ADS  Google Scholar 

  37. E. C. Le Ru, E. B lackie, M. Meyer, and P. G. Etchegoin, J. Phys. Chem. C, 111, 13794–13803 (2007).

  38. O. Kulakovich, A. Matsukovich, and L. Trotsiuk, J. Nanophotonics, 16, Article ID 046002 (2022).

  39. A. Y. Mahmoud, C. J. Rusin, and M. T. McDermott, Analyst, 145, 1396–1407 (2020).

    Article  ADS  Google Scholar 

  40. L. Zhang, C. Guan, Y. Wang, and J. Liao, Nanoscale, 8, 5928–5937 (2016).

    Article  ADS  Google Scholar 

  41. M. Blanco‐Formoso, N . Pazos‐Perez, R. and A. Alvarez‐Puebla, J. Raman Spectrosc., 52, 554–562 (2021).

  42. G. L. Long and J. D. Win efordner, Anal. Chem., 55, 712A–724A (1983).

  43. B. Saute, R. Premasiri, L. Ziegler, and R. Narayanan, Analyst, 137, 5082–5087 (2012).

    Article  ADS  Google Scholar 

  44. J. Midelet, A. H. El‐Saghe er, T. Brown, A. G. Kanaras, and M. H. Werts, Part. Part. Syst. Charact., 34, Article ID 1700095 (2017).

  45. Q. Zhang, Y. Yuan, C. Wang, Z. Zhou, L. Li, S. Zhang, and J. Xu, J. Raman Spectrosc., 47, 395–401 (2016).

    Article  ADS  Google Scholar 

  46. O. Kulakovich, E. Shabunya-Klyachkovskaya, A. Matsukovich, L. Trotsiuk, and S. Gaponenko, J. Appl. Spectrosc., 83, 860–863 (2016).

    Article  ADS  Google Scholar 

  47. L. G. Olson, R. H. Uibel, and J. M. Harris, Appl. Spectrosc., 58, 1394–1400 (2004).

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. Physics Department, Faculty of Science, Ain Shams University, Cairo, Egypt

    H. M. Saleh, T. El-Brolossy, T. Sharaf & H. Talaat

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  1. H. M. Saleh
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  2. T. El-Brolossy
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  3. T. Sharaf
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  4. H. Talaat
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Corresponding author

Correspondence to T. Sharaf.

Additional information

Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 91, No. 6, p. 913, November–December, 2024.

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Saleh, H.M., El-Brolossy, T., Sharaf, T. et al. SERS Substrates for Ultrasensitive Detection of Malachite Green Using Silver Nanostars. J Appl Spectrosc 91, 1343–1352 (2025). https://doi.org/10.1007/s10812-025-01859-4

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  • DOI: https://doi.org/10.1007/s10812-025-01859-4

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