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Seaweeds with anti-herpes simplex virus type 1 activity

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Abstract

Many compounds derived from marine organisms have new and unusual structures with significant biological activities, and pharmacological properties, including antiviral activity, of seaweed natural products, have been discovered. The herpes simplex virus type 1 (HSV-1) infection is endemic worldwide and is one of the most prevalent infections in Brazil. Although several antiviral substances are available for the treatment of individuals infected with herpes simplex virus type 1, the development of resistant mutations of herpes viruses, the side effects associated with the drugs available, and the occurrence of severe cases of the disease have shown the importance of the search for new effective therapies against herpes. Hence, the aim of this review is to summarize and discuss the information on the extracts and isolated molecules from different seaweeds with anti-herpes simplex virus type 1 activity. Perspectives for choosing classes and orders of algae for future studies with this activity are discussed.

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Acknowledgments

The authors are grateful to CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for financial support and to ICNPP and VLT for Productivity Fellowships. The authors also thank the FAPERJ (Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro) for Cientista do Nosso Estado Fellowship. CSB thanks FAPERJ for the DSc fellowship.

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  1. Programa Pós-graduação em Ciências e Biotecnologia (PPBI), Universidade Federal Fluminense (UFF), Niterói, RJ, 24020-150, Brazil

    Caroline de Souza Barros

  2. Laboratório ALGAMAR, Departamento de Biologia Marinha, Instituto de Biologia (UFF), P.O. Box 100.644, Niterói, RJ, 24001-970, Brazil

    Valéria Laneuville Teixeira

  3. Laboratório de Virologia Molecular e Biotecnologia Marinha, Departamento de Biologia Celular e Molecular, Instituto de Biologia (UFF), Niterói, RJ, 24020-150, Brazil

    Caroline de Souza Barros & Izabel Christina N. P. Paixão

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  1. Caroline de Souza Barros
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Correspondence to Valéria Laneuville Teixeira or Izabel Christina N. P. Paixão.

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de Souza Barros, C., Teixeira, V.L. & Paixão, I.C.N.P. Seaweeds with anti-herpes simplex virus type 1 activity. J Appl Phycol 27, 1623–1637 (2015). https://doi.org/10.1007/s10811-014-0447-7

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