Skip to main content
Log in

Seaweed biotechnology in Brazil: six decades of studies on natural products and their antibiotic and other biological activities

  • IV Latin American Congress of Algae Biotechnology (CLABA) and IV Redealgas Workshop
  • Published:
Journal of Applied Phycology Aims and scope Submit manuscript

Abstract

The Brazilian seaweed assemblage currently comprises 770 taxa, distributed along 7,367 km of coastline with highly diverse ecological conditions, suggesting a high biotechnological potential for these species. Studies on seaweed biotechnology in Brazil began in 1948 and have produced extensive published information that is presently scattered in many sources. This manuscript presents an overview of biotechnology studies on seaweeds that were carried out in Brazil, from the earliest through 2012, with the purpose of directing new studies in this field. The studies analyzed were retrieved from the curricula of Brazilian seaweed researchers, centralized in the public database Currículo Lattes, supported by the Brazilian National Council of Technological and Scientific Development (CNPq). Scientific papers dealing with biological activities of natural extracts from native and some non-native seaweeds were selected. The survey was complemented by a search for older references cited in the first group. Together, the studies extend over 64 years, totaling 364 scientific papers investigating the potential of 160 seaweed taxa, including tests for 6 antibiotic activities, 11 categories of other biological activities, and a wide range of natural products. In general, the studies focused on antiinflammatory, antinociceptive, and antiviral activities, and some characterized the effects of molecules, including sulfated polysaccharides, lectins, and terpenes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abreu TM, Silva LMCM, Vanderlei ESO, de Melo CM, Pereira VR, Barros Benevides NM (2012) Cytokine production induced by Solieria filiformis, Pterocladiella capilaceae and Caulerpa cupressoides marine algae lectins in Balb/c mice splenocytes. Protein Pept Lett 19:975–981

    Google Scholar 

  • Ainouz IL, Sampaio AH (1991) Screening of Brazilian marine algae for hemagglutinins. Bot Mar 34:211–214

    CAS  Google Scholar 

  • Ainouz IL, Sampaio AH, Benevides NMB, Freitas ALP, Costa FHF, Cavalho MR, Pinheiro-Joventino F (1992) Agglutination of enzyme treated erythrocytes by Brazilian marine algal extracts. Bot Mar 35:475–479

    CAS  Google Scholar 

  • Ainouz IL, Sampaio AH, Freitas ALP, Benevides NMB, Mapurunga S (1995) Comparative study on hemagglutinin from the red algae Bryothamnion seaforthii and Bryothamnion triquetrum. Rev Bras Fisiol Veg 7:15–19

    CAS  Google Scholar 

  • Alencar DB, Pires-Cavalcante KMS, Sousa MB, Viana FA, Saker-Sampoio S (2011) Aminas biogênicas em macroalgas marinhas do Estado do Ceará, Brasil. Rev Ciênc Agron 42:349–353

    Google Scholar 

  • Alves MGCF, Dore CMPG, Castro AJG, do Nasciemto MS, Cruz AKM, Soriano EM, Benevides MNB, Leite EL (2012) Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis. J Appl Phycol 24:1217–1227

    CAS  Google Scholar 

  • Amorim RNS, Rodrigues JAG, Holanda ML, Mourão P, Benevides N (2011) Anticoagulant properties of a crude sulfated polysaccharide from the red marine alga Halymenia floresia (Clemente) C. Agardh. Acta Sci Biol Sci 33:255–261

    CAS  Google Scholar 

  • Amorim RNS, Rodrigues JAG, Holanda ML, Quinderé ASLG, de Paula RCM, Melo VMM, Benevides NMB (2012) Antimicrobial effect of a crude sulfated polysaccharide from the red seaweed Gracilaria ornata. Braz Arch Biol Technol 55:171–181

    CAS  Google Scholar 

  • Andrade L, Amado-Filho GM (2004) Ultrastructure of acidic polysaccharides from the cell walls of brown algae. J Struct Biol 145:216–225

    PubMed  CAS  Google Scholar 

  • Andrade Moura L, Bianco EM, Pereira RC, Teixeira VL, Fuly AL (2011) Anticoagulation and antiplatelet effects of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis. J Thromb Thrombolysis 31:235–240

    PubMed  CAS  Google Scholar 

  • Antunes BL, Fleury BG, Fujii MT, Teixeira VL (2008) Sesquiterpenes of the Brazilian marine red alga Laurencia filiformis (Rhodophyta, Ceramiales). Nat Prod Commun 3:1653–1654

    CAS  Google Scholar 

  • Appelhans YS, Lenz M, Medeiros HE, de Gama BAP, Pereira RC, Wahl M (2010) Stressed, but not defenseless: no obvious influence of irradiation levels on antifeeding and antifouling defences of tropical macroalgae. Mar Biol 157:1151–1159

    Google Scholar 

  • Araújo GS, Torres VM, Marreiro FM, Lavor AMC, Farias WRL (2009) Cultivo de micro e macroalgas marinhas em condições controladas e extração de polissacarídeos sulfatados. Arq Ciênc Mar 42:1–7

    Google Scholar 

  • Araújo IWF, Vanderlei ESO, Rodrigues JAG, Coura CO, Quinderé ALG, Fontes BP, de Queiroz INL, Jorge RJB, Bezerra MM, Rodrigues e Silva AA, Chaves HV, Monteiro HSA, de Paula RCM, Benevides NMB (2011) Effects of a sulfated polysaccharide isolated from the red seaweed Solieria filiformis on models of nociception and inflammation. Carbohydr Polym 86:1207–1215

    Google Scholar 

  • Araújo IWF, Rodrigues JAG, Vanderlei ESO, de Paula GA, Lima TB, Benevides NMB (2012) Iota-carrageenans from Solieria filiformis (Rhodophyta) and their effects in the inflammation and coagulation. Acta Sci Technol 34:127–135

    Google Scholar 

  • Ascêncio SD, Orsato A, França RA, Duarte ER, Noseda MD (2006) Complete 1H and 13C NMR assignment of digeneaside, a low-molecular-mass carbohydrate produced by red seaweeds. Carbohydr Res 341:677–682

    PubMed  Google Scholar 

  • Assreuy AMS, Gomes DM, da Silva MSJ, Torres VM, Siquera RC, Pires Ade F, Criddle CN, de Alencar NM, Cavada BS, Sampaio AH, Farias WR (2008) Biological effects of a sulfated-polysaccharide isolated from the marine red algae Champia feldmannii. Biol Pharm Bull 31:691–695

    PubMed  CAS  Google Scholar 

  • Azevedo TCG, Bezerra MEB, Santos MGL, Souza LA, Marques CT, Benevides NMB, Leite EL (2009) Heparinoids algal and their anticoagulant, hemorrhagic activities and platelet aggregation. Biomed Pharmacother 63:477–483

    PubMed  Google Scholar 

  • Barbosa JP, Teixeira VL, Villaça R, Pereira RC, Abrantes JL, Frugulhetti ICPP (2003) A dolabellane diterpene from the Brazilian brown alga Dictyota pfaffii Schnetter. Biochem Syst Ecol 31:1451–1453

    CAS  Google Scholar 

  • Barroso FEC, Rodrigues JAG, Torres VM, Sampaio AH, Farias WRL (2007) Efeito do polissacarídeo sulfatado extraído da alga marinha vermelha Botryocladia occidentalis nas pós-larvas do camarão Litopenaeus vannamei. Rev Ciênc Agron 38:58–63

    Google Scholar 

  • Benevides NMB, Holanda ML, Melo FR, Sampaio AH, Freitas ALP (1998) Purification and partial characterization of the lectin from the red marine alga Enantiocladia duperreyi. Bot Mar 41:521–525

    CAS  Google Scholar 

  • Benevides NMB, Oliveira SRM, Holanda ML, Melo FR, Freitas ALP, Sampaio AH (1999) Seasonal variations in hemagglutinating activity and chemical composition of two red marine algae Gracilaria domingensis and Gelidium pusillum. Rev Bras Fisiol Veg 11:91–95

    CAS  Google Scholar 

  • Bianco EM, Rogers R, Teixeira VL, Pereira RC (2009) Antifoulant diterpenes produced by the brown seaweed Canistrocarpus cervicornis. J Appl Phycol 21:341–346

    CAS  Google Scholar 

  • Bicudo CEM, Menezes M (2010) As algas do Brazil. In: Forzza RC (ed) Catálogo de plantas e fungos do Brasil. Vol. 1. Andrea Jakobsson Estúdio. Instituto de Pesquisas Jardim Botânico do Rio de Janeiro, Rio de Janeiro, pp 49–60

    Google Scholar 

  • Bitencourt FS, Figueiredo JG, Mota MRL, Bezerra CR, Silvestre P, Vale M, Nascimento K, Sampaio A, Nagano C, Saker-Sampaio S, Farias WL, Cavada B, Assreuy AS, Alencar NN (2008) Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn Schmiedebergs Arch Pharmacol 377:139–148

    CAS  Google Scholar 

  • Camara RBG, Costa LS, Fidelis GP, Nobre LTDB, Dantas-Santos N, Cordeiro SL, Costa MSSP, Alves LG, Rocha HAO (2011) Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities. Mar Drugs 9:124–138

    PubMed  CAS  PubMed Central  Google Scholar 

  • Câmara-Neto C, Chaves-Câmara I (2012) Universidade de Palha – A saga das algas marinhas do litoral do Rio Grande do Norte. Fundação José Augusto, Natal

  • Cardoso MA, Noseda MD, Fujii MT, Zibetti RG, Duarte ME (2007) Sulfated xylomannans isolated from red seaweeds Chondrophycus papillosus and C. flagelliferus (Ceramiales) from Brazil. Carbohydr Res 342:2766–2775

    PubMed  CAS  Google Scholar 

  • Cardoso M, Xavier C, Bezerra M, Paiva A, Carvalho MF, Benevides NM, Rocha FA, Leite EL (2010) Assessment of zymosan-induced leukocyte influx in a rat model using sulfated polysaccharides. Planta Med 76:113–119

    PubMed  CAS  Google Scholar 

  • Cardozo KHM, Marques LG, Carvalho MV, Carignan MO, Pinto E, Marinho-Soriano E, Colepicolo P (2011) Analyses of photoprotective compounds in red algae from the Brazilian coast. Rev Bras Farmacogn 21:202–208

    CAS  Google Scholar 

  • Carvalho LR, Fujii MT, Roque NF, Lago JHG (2006) Aldingenin derivatives from the red alga Laurencia aldingensis. Phytochemistry 67:1331–1335

    PubMed  Google Scholar 

  • Cassano V, Paula JC, Fujii MT, Gama BAP, Teixeira VL (2008) Sesquiterpenes from the introduced red seaweed Laurencia caduciramulosa (Rhodomelaceae, Ceramiales). Biochem Syst Ecol 36:223–226

    CAS  Google Scholar 

  • Cassolato J, Noseda M, Pujol C, Pellizzari FM, Damonte E, Duarte ME (2008) Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma. Carbohydr Res 343:3085–3095

    PubMed  CAS  Google Scholar 

  • Cavalcante-Silva LHA, Barbosa Brito da Matta C, de Araújo MV, Barbosa-Filho JM, Pereira de Lira D, de Oliveira Santos BV, de Miranda GEC, Alexandre-Moreira MS (2012) Antinociceptive and anti-inflammatory activities of crude methanolic extract of red alga Bryothamnion triquetrum. Mar Drugs 10:1977–1992

    PubMed  PubMed Central  Google Scholar 

  • Cavalcanti DN, Gomes MAV, Pinto AC, Rezende CM, Pereira RC, Teixeira VL (2008) Effects of storage and solvent type in a lipophylic chemical profile of the seaweed Dictyota menstrualis. Braz J Oceanogr 56:51–57

    Google Scholar 

  • Cirne-Santos CC, Teixeira VL, Castello-Branco L, Frugulhetti IC, Bou-Habib DC (2006) Inhibition of HIV-1 replication in human primary cells by triol, a diterpene isolated from the marine alga Dictyota pfaffii. Planta Med 72:295–299

    PubMed  CAS  Google Scholar 

  • Cosson J, Yoneshigue-Valentin Y, Deslandes E, Coat G, Floch J (1995) Résultats préliminaires sur la composition en alginates de Laminaria abyssalis des côtes brésiliennes. Act Bot Gall 142:137–140

    CAS  Google Scholar 

  • Costa FHF, Sampaio AH, Neves SA, Rocha MLA, Benevides NMB, Freitas ALP (1999) Purification and characterisation of a lectin from the red marine alga Amansia multifida. Physiol Mol Biol Plants 5:53–61

    Google Scholar 

  • Costa LS, Fidelis GP, Cordeiro SL, Oliveira RM, Sabry DA, Câmara RBG, Nobre LTDB, Costa MSSP, Almeida-Lima J, Farias EHC, Leite EL, Rocha HAO (2010) Biological activities of sulfated polysaccharides from tropical seaweeds. Biomed Pharmacother 64:21–28

    PubMed  CAS  Google Scholar 

  • Costa LS, Fidelis GP, Telles CB, Dantas-Santos N, Camara RB, Cordeiro SL, Pereira-Costa MS, Almeida-Lima J, Melo-Silveira RF, Oliveira RM et al (2011) Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula. Mar Drugs 9:952–966

    PubMed  CAS  PubMed Central  Google Scholar 

  • Costa MSSP, Costa LS, Cordeiro SL, Almeida-Lima J, Dantas-Santos N, Magalhães KD, Sabry DA, Albuquerque IRL, Pereira MR, Leite EL, Rocha HAO (2012) Evaluating the possible anticoagulant and antioxidant effects of sulfated polysaccharides from tropical seaweed Caulerpa cupressoides var. flabellata. J Appl Phycol 24:1159–1167

    CAS  Google Scholar 

  • Coura CO, de Araújo IWF, Vanderlei ESO, Rodrigues JAG, Quinderé ALG, Fontes BP, de Queiroz INL, de Menezes DB, Bezerra MM, e Silva AAR, Chaves HV, Jorge RJB, Evangelista JSAM, Benevides NMB (2012) Antinociceptive and anti-inflammatory activities of sulfated polysaccharides from the red seaweed Gracilaria cornea. Basic Clin Pharmacol Toxicol 110:335–341

    PubMed  CAS  Google Scholar 

  • Davyt D, Fernandez R, Suescun L, Mombrú AW, Saldaña J, Domínguez L, Coll J, Fujita MT, Manta E et al (2001) New sesquiterpene derivatives from the red alga Laurencia scoparia. Isolation, structure determination, and anthelmintic activity. J Nat Prod 64:1552–1555

    PubMed  CAS  Google Scholar 

  • de Paula JC, Pedrini AG, Pinheiro MD, Pereira RC, Teixeira VL (2001) Chemical similarity between the brown algae Dictyota cervicornis and Dictyota pardalis (Dictyotales, Phaeophyta). Biochem Syst Ecol 29:425–427

    Google Scholar 

  • de Paula JC, Cassano V, Yoneshigue-Valentin Y, Teixeira VL (2007) Diterpenes from the Brazilian brown alga Dictyota crispata (Dictyotaceae, Phaeophyta). Nat Prod Commun 2:135–137

    Google Scholar 

  • de Paula JC, Bueno LB, Cavalcanti DN, Yoneshigue-Valentin Y, Teixeira VL (2008) Diterpenes from the brown alga Dictyota crenulata. Molecules 13:1253–1262

    Google Scholar 

  • de Paula JC, Cavalcanti DN, Yoneshigue-Valentin Y, Teixeira VL (2012) Diterpenes from marine brown alga Dictyota guineensis (Dictyotaceae, Phaeophyceae). Rev Bras Farmacogn 22:736–740

    Google Scholar 

  • Dietrich CP, Farias GGM, Leite EL, Silva LF, Nader HB (1995) A new approach for the characterization of polysaccharides from algae: presence of four main acidic polysaccharides in the three species of the class Phaeophyceae. Plant Sci 108:143–153

    CAS  Google Scholar 

  • Domingos TFS, Ortiz-Ramírez FA, Villaça RC, Cavalcanti DN, Sanchez EF, Teixeira VL, Fuly AL (2012) Inhibitory effect of a Brazilian marine brown alga Spatoglossum schroederi on biological activities of Lachesis muta snake venom. Rev Bras Farmacogn 22:741–747

    CAS  Google Scholar 

  • Duarte M (2002) The structure of a galactan sulfate from the red seaweed Bostrychia montagnei. Carbohydr Res 337:1137–1144

    PubMed  CAS  Google Scholar 

  • Duarte MER, Gorin PAJ, Duarte JH (1991) Homogeneous guluronic and mannuronic acid blocks in the alginate of the brown seaweed Laminaria brasiliensis. Phytochemistry 30:1707–1708

    CAS  Google Scholar 

  • Duarte MER, Cardoso MA, Noseda MD, Cerezo AS (2001a) Structural studies on fucoidans from brown seaweed Sargassum stenophyllum. Carbohydr Res 333:281–293

    PubMed  CAS  Google Scholar 

  • Duarte MER, Noseda DG, Noseda MD, Tulio S, Pujol CA, Damonte EB (2001b) Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro. Phytomedicine 8:53–58

    PubMed  CAS  Google Scholar 

  • Duarte MER, Cauduro JP, Noseda DG, Noseda MD, Gonçalves AG, Pujol CA, Damonte EB, Cerezo AS (2004) The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity: relation between structure and antiviral activity. Carbohydr Res 339:335–347

    PubMed  CAS  Google Scholar 

  • Durairatnam M (1987) Studies of the yield of agar, gel strength and quality of agar of Gracilaria edulis (Gmel.) Silva from Brazil. Hydrobiologia 151/152:509–512

  • Faria PCS, Noseda MD, Freitas RA, Sierakowski MR, Duarte MER (2006a) Effects of iota-carrageenan on the rheological properties of starches. Carbohydr Polym 65:49–57

    Google Scholar 

  • Faria PCS, Talarico LB, Noseda MD, Guimarães SMPB, Damonte EB, Duarte MER (2006b) Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydr Polym 63:459–465

    Google Scholar 

  • Farias WRL, Valente AP, Pereira MS, Mourão PAS (2000) Structure and anticoagulant activity of sulfated galactans: isolation of a unique sulfated galactan from the red algae Botryocladia occidentalis and comparison of its anticoagulant action with that of sulfated galactans from invertebrates. J Biol Chem 275:29299–29307

    PubMed  CAS  Google Scholar 

  • Farias WRL, Lima PCWC, Rodrigues NVFC, Siqueira RC, Amorim RM, Pereira MG, Assreuy AM (2011) A novel antinociceptive sulphated polysaccharide of the brown marine alga Spatoglossum schroederi. Nat Prod Commun 6:863–866

    PubMed  CAS  Google Scholar 

  • Felício R, Albuquerque S, Young MCM, Yokoya NS, Debonsi HM (2010) Trypanocidal, leishmanicidal and antifungal potential from marine red alga Bostrychia tenella J. Agardh (Rhodomelaceae, Ceramiales). J Pharm Biomed Anal 52:763–769

    PubMed  Google Scholar 

  • Ferreira LG, Noseda MD, Gonçalves AG, Ducatti DRB, Fujii MT, Duarte MER (2012a) Chemical structure of the complex pyruvylated and sulfated agaran from the red seaweed Palisada flagellifera (Ceramiales, Rhodophyta). Carbohydr Res 347:83–94

    PubMed  CAS  Google Scholar 

  • Ferreira LS, Turatti ICC, Lopes NP, Guaratini T, Colepicolo P, Oliveira Filho EC, Garla RC (2012b) Apolar compounds in seaweeds from Fernando de Noronha Archipelago (northeastern coast of Brazil). Int J Anal Chem 2012:431954

    PubMed Central  Google Scholar 

  • Ferreira LS, Oliveira Filho EC, Ulbrich MNC et al (2012c) Concentration of inorganic elements content in benthic seaweeds of Fernando de Noronha archipelago by synchrotron radiation total reflection x-ray fluorescence analysis (srtxrf). Int J Anal Chem 2012:407274

    PubMed Central  Google Scholar 

  • Figueiredo JG, Bitencourt FS, Cunha TM, Luz PB, Nascimento KS, Mota MR, Sampaio AH, Cavada BS, Cunha FQ, Alencar NM (2010) Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: involvement of nitric oxide. Pharmacol Biochem Behav 96:371–377

    PubMed  CAS  Google Scholar 

  • Fleury BG, Kelecom A, Pereira RC, Teixeira VL (1994a) Polyphenols, terpenes and sterols in Brazilian Dictyotales and Fucales (Phaeophyta). Bot Mar 37:457–462

    CAS  Google Scholar 

  • Fleury BG, Pereira MVG, Silva JRP, Kaisin M, Teixeira VL, Kelecom A (1994b) Sterols from Brazilian marine brown algae. Phytochemistry 37:1447–1449

    CAS  Google Scholar 

  • Freitas ALP, Sampaio AH, Ainouz IL, Benevides NMB, Mapurunga S (1995) Comparative study on hemagglutinins from the red algae Bryothamnion seaforthii and Bryothamnion triquetrum. Rev Bras Fisiol Veg 7:15–19

    Google Scholar 

  • Freitas ALP, Teixeira DIA, Costa FHF, Farias WRL, Lobato ASC, Sampaio AH, Benevides NMB (1997) A new survey of Brazilian marine algae for agglutinins. J Appl Phycol 9:495–501

    CAS  Google Scholar 

  • Freitas OSP, Oliceira AS, de-Paula JC, Pereira RC, Cavalcanti DN, Teixeira VL (2007) Chemical variation in the diterpenes from the Brazilian brown alga Dictyota mertensii (Dictyotaceae, Phaeophyta). Nat Prod Commun 2:13–15

    CAS  Google Scholar 

  • Garrido V, Teixeira GAPB, Teixeira VL, Ocampo P, Ferreira WJ, Cavalcanti DN, Campos SMN, Pedruzzi MMB, Olaya P, dos Santos CCC, Giongo V, Paixão ICP (2011) Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice. Rev Bras Farmacogn 21:209–215

    CAS  Google Scholar 

  • Gonçalves AG, Ducatti DRB, Grindley TB, Duarte MER, Noseda MD (2010) ESI-MS differential fragmentation of positional isomers of sulfated oligosaccharides derived from carrageenans and agarans. J Am Soc Mass Spectrom 21:1404–1416

    PubMed  Google Scholar 

  • Gressler V, Fujii MT, Pinto E, Colepicolo P (2012) Characterization of volatile composition of Laurencia dendroidea by gas chromatography–mass spectrometry. Rev Bras Farmacogn 22:805–813

    CAS  Google Scholar 

  • Guarantini T, Lopes NP, Marinho-Soriano E, Lopes NP, Pinto E, Colepicolo P (2012) Antioxidant activity and chemical composition of the non-polar fraction of Gracilaria domingensis (Kützing) Sonder ex Dickie and Gracilaria birdiae (Plastino & Oliveira). Rev Bras Farmacogn 22:724–729

    Google Scholar 

  • Guimarães M, Viana AG, Duarte MER, Ascêncio SD, Plastino EM, Noseda MD (2007) Low-molecular-mass carbohydrates and soluble polysaccharides of green and red morphs of Gracilaria domingensis (Gracilariales, Rhodophyta). Bot Mar 50:314–317

    Google Scholar 

  • Hazin FHV, Wor C, Oliveira JEL, Hamilton S, Travassos P, Geber F (2008) Results obtained by the mooring of a current meter on the continental shelf of Rio Grande do Norte State, Brazil. Arq Ciênc Mar 41:30–35

    Google Scholar 

  • Holanda ML, Melo VMM, Silva LMCM, Amorim RCN, Pereira MG, Benevides NMB (2005) Differential activity of a lectin from Solieria filiformis against human pathogenic bacteria. Braz J Med Biol Res 38:1769–1773

    PubMed  CAS  Google Scholar 

  • Horta PA (2000) Macroalgas do infralitoral do sul e sudeste brasileiro. Thesis, University of São Paulo

  • Humm HJ, Williams LG (1948) A study of agar from two Brazilian seaweeds. Am J Bot 35:287–292

    CAS  Google Scholar 

  • IBGE (2013) Mão na roda » posição e extensão. IBGE- Instituto Brasileiro de Geografia e Estatística. http://teen.ibge.gov.br/mao-na-roda/posicao-e-extensao. Accessed 14 Dec 2013

  • Kirchhoff VWJH, Echer E, Leme NP, Silva AA (2000) A variação sazonal da radiação ultravioleta solar biologicamente ativa. Rev Bras Geofís 18:63–74

    Google Scholar 

  • Leite EL, Medeiros MGL, Rocha HAO, Farias GGM, da Silva LF, Chavante SF, de Abreu LD, Dietrich CP, Nader HB (1998) Structure and pharmacological activities of a sulfated xylofucanglucuronan from the algae Spatoglossum scroederi. Plant Sci 14:215–228

    Google Scholar 

  • Leite EL, Araujo PM, Oliveira GB (2004) Sulfated fucan as support for antibiotic immobilization. Braz J Med Biol Res 37(3):301–305

    PubMed  Google Scholar 

  • Leite YFMM, Silva LMCM, Amorim RCN, Freire EA, de Melo Jorge DM, Grangeiro TB, Benevides NMB, Marques YFM, Silva LMCM, Amorim RCN et al (2005) Purification of a lectin from the marine alga Gracilaria ornata and its effect on the development of the cowpea weevil Callosobruchus maculatus (Coleoptera: Bruchidae). Biochim Biophys Acta 1724:137–145

    PubMed  CAS  Google Scholar 

  • Lhullier C, Horta PA, Falkenberg M (2006) Avaliação de extratos de macroalgas bênticas do litoral catarinense utilizando o teste de letalidade para Artemia salina. Rev Bras Farmacogn 16:158–163

    Google Scholar 

  • Lhullier C, Falkenberg M, Ioannou E, Quesada A, Papazafiri P, Horta PA, Schenkel EP, Vagias C, Roussis V (2010) Cytotoxic halogenated metabolites from the Brazilian red alga. J Nat Prod 73:27–32

    PubMed  CAS  Google Scholar 

  • Lima HC, Costa FHF, Sampaio AH, Neves AS, Benevides NMB, Teixeira DIA, Rogers DJ, Freitas ALP (1998) Induction and inhibition of human lymphocyte transformation by the lectin from the red marine alga Amansia multifida. J Appl Phycol 10:153–162

    CAS  Google Scholar 

  • Lima MEP, Carneiro ME, Nascimento AE et al (2005) Purification of a lectin from the marine red alga Gracilaria cornea and its effects on the Cattle Tick Boophilus microplus (Acari: Ixodidae). J Agric Food Chem 53:6414–6419

    PubMed  CAS  Google Scholar 

  • Lima-Filho JVM, Carvalho AFFU, Sissi MF, Melo VMM (2002) Antibacterial activity of extracts of six macroalgae from the northeastern Brazilian coast. Braz J Microbiol 33:311–313

    Google Scholar 

  • Lins KOAL, Bezerra DP, Alves APNN, Alencar NMN, Lima MW, Torres VM, Farias WRL, Pessoa C, de Moraes MO, Costa-Lotufo LV (2009) Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer). J Appl Toxicol 29:20–26

    PubMed  CAS  Google Scholar 

  • Lourenço SO, Barbarino E, Paula JC, Pereira LOS, Marquez UML (2002) Amino acid composition, protein content and calculation of nitrogen-to-protein conversion factor for 19 tropical seaweeds. Phycol Res 50:233–241

    Google Scholar 

  • Macchiavello J, Saito R, Garófalo G, Oliveira-Filho EC (1999) A comparative analysis of agarans from commercial species of Gracilaria (Gracilariales, Rhodophyta) from Brazil. Hydrobiologia 399:105–108

    Google Scholar 

  • Machado FS, Pacienza-Lima W, Rossi-Bergmann B, Gestinari LMS, Fujii MT, de Paula JC, Costa SS, Lopes NP, Kaiser CR, Soares AR (2011) Antileishmanial sesquiterpenes from the Brazilian red alga Laurencia dendroidea. Planta Med 77:733–735

    CAS  Google Scholar 

  • Maciel JS, Chaves LS, Souza BWS, Teixeira DIA, Freitas ALP, Feitosa JPA, de Paula RCM (2008) Structural characterization of cold extracted fraction of soluble sulfated polysaccharide of red seaweed Gracilaria birdiae. Carbohydr Polym 71:559–565

    CAS  Google Scholar 

  • Magalhães KD, Costa LS, Fidelis GP, Oliveira RM, Nobre LT, Dantas-Santos N, Camara RB, Albuquerque IR, Cordeiro SL, Sabry DA, Costa MS, Alves LG, Rocha HA (2011) Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula. Int J Mol Sci 12:3352–3365

    PubMed  PubMed Central  Google Scholar 

  • Mandelli MQ (1964) Sobre a composição química de algumas espécies de algas marinhas brasileiras. Ciênc Cult 16:281–284

    CAS  Google Scholar 

  • Marinho-Soriano E, Bourret E (2004) Polysaccharides from the red seaweed Gracilaria dura (Gracilariales, Rhodophyta). Biores Technol 96:379–382

    Google Scholar 

  • Marinho-Soriano E, Silva TSF, Moreira WSC (2001) Seasonal variation in the biomass and agar yield from Gracilaria cervicornis and Hydropuntia cornea from Brazil. Biores Technol 77:115–120

    CAS  Google Scholar 

  • Marques CT, Azevedo TCG, Nascimento MS, Medeiros VP, Alves LG, Benevides NMB, Rocha HAO, Leite EL (2012) Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect. Rev Bras Farmacogn 23:115–122

    Google Scholar 

  • Martins CDL, Ramlov F, Nocchi Carneiro NP, Gestinari LM, dos Santos BF, Bento LM, Lhullier C, Gouvea L, Bastos E, Horta PA, Soares AR (2012a) Antioxidant properties and total phenolic contents of some tropical seaweeds of the Brazilian coast. J Appl Phycol 25:1179–1187

    Google Scholar 

  • Martins AP, Yokoya NS, Colepicolo P (2012b) Comparison of extraction and transesterification methods on the determination of the fatty acid contents of three Brazilian seaweed species. Rev Bras Farmacogn 22:854–860

    CAS  Google Scholar 

  • Matta CBB, De Souza ÉT, De Queiroz AC, De Lira DP, De Araújo MV, Cavalcante-Silva LHA, De Miranda GEC, De Araújo-Júnior JX, Barbosa-Filho JM, De Oliveira Santos BV, Alexandre-Moreira MS (2011) Antinociceptive and anti-inflammatory activity from algae of the genus Caulerpa. Mar Drugs 9:307–318

    PubMed  PubMed Central  Google Scholar 

  • Mattos BB, Romanos MTV, Souza LM, Sassaki G, Barreto-Bergter E (2011) Glycolipids from macroalgae: potential biomolecules for marine biotechnology? Rev Bras Farmacogn 21:244–247

    CAS  Google Scholar 

  • Medeiros HE, Gama BAP, Gallerani G (2007) Antifouling activity of seaweed extracts from Guarujá, São Paulo, Brazil. Braz J Oceanogr 55:257–264

    Google Scholar 

  • Medeiros VP, Queiroz KCS, Cardoso ML, Monteiro GRG, Oliveira FW, Chavante SF, Guimaraes LA, Rocha HAO, Leite EL et al (2008) Sulfated galactofucan from Lobophora variegata: anticoagulant and anti-inflammatory properties. Biochemistry 73:1018–1024

    PubMed  CAS  Google Scholar 

  • Melo MRS, Feitosa JPA, Freitas ALP, Paula RCM (2002) Isolation and characterization of soluble sulfated polysaccharide from Gracilaria cornea red seaweed. Carbohydr Polym 49:491–498

    CAS  Google Scholar 

  • Melo KRT, Lima JA, Santos ND, Camara RBG, Rocha HAO (2012) Caracterização e atividade anticoagulante de polissacarídeos sulfatados extraídos da alga marrom Dictyopteris justii. Holos 1:29–40

    Google Scholar 

  • Moura LA, Sanchez EF, Bianco ÉM, Pereira RC, Teixeira VL, Fuly AL et al (2011) Antiophidian properties of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis. Biomed Prev Nutr 1:61–66

    Google Scholar 

  • Nagano CS, Debray H, Nascimento KS, Pinto VPT, Cavada BS, Saker-Sampaio S, Farias WRL, Sampaio AH, Calvete JJ (2005) HCA and HML isolated from the red marine algae Hypnea cervicornis and Hypnea musciformis define a novel lectin family. Prot Sci 14:2167–2176

    CAS  Google Scholar 

  • Nascimento KS, Nagano CS, Nunes EV, Rodrigues RF, Goersch GV, Cavada BS, Calvete JJ, Saker-Sampaio S, Farias WRL, Sampaio AH (2006) Isolation and characterization of a new agglutinin from the red marine alga Hypnea cervicornis J. Agardh. Biochem Cell Biol 84:49–54

    PubMed  CAS  Google Scholar 

  • Nascimento-Neto LG, Carneiro RF, da Silva SR, da Silva BR, Arruda FVS, Carneiro VA, do Nascimento KS, Saker-Sampaio S, da Silva VA, Porto AL, Cavada BS, Sampaio AH, Teixeira EH, Nagano CS et al (2012) Characterization of isoforms of the lectin isolated from the red algae Bryothamnion seaforthii and its pro-healing effect. Mar Drugs 10:1936–1954

    PubMed  PubMed Central  Google Scholar 

  • Noseda MD, Tulio S, Duarte MER (1999) Polysaccharides from the red seaweed Bostrychia montagnei: chemical characterization. J Appl Phycol 11:35–40

    CAS  Google Scholar 

  • Noseda AMD, Viana AG, Duarte MER, Cerezo AS (2000) Alkali modification of carrageenans. Part IV. Porphyrans as model compounds. Carbohydr Polym 42:301–305

    CAS  Google Scholar 

  • Oliveira SEM, Nascimento AE, Lima MEP, Marques YFM, Benevides NMB (2002) Purification and characterization of a lectin from the red marine alga Pterocladia capillacea Santel & Hommers. Rev Bras Bot 25:397–403

    CAS  Google Scholar 

  • Oliveira SCB, Fonseca FV, Antunes E, Camargo EA, Morganti RP, Aparício R, Toyama DO, Beriam LOS, Nunes EV, Cavada BS, Nagano CS, Sampaio AH, Nascimento KS, Toyama MH (2008) Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga. BMC Biochem 9:16

    PubMed  PubMed Central  Google Scholar 

  • Oliveira ALL, Silva DB, Turatti ICC, Yokoya NS, Debonsi HM (2009) Volatile constituents of Brazilian Bostrychia species (Rhodomelaceae) from mangrove and rocky shore. Biochem Syst Ecol 37:761–765

    Google Scholar 

  • Oliveira ALL, Bentran D, Lopes NP, Yokoya NS, Debonsi HM (2012) Chemical constituents from red algae Bostrychia radicans (Rhodomelaceae): new amides and phenolic compounds. Quím Nova 35:2186–2188

    Google Scholar 

  • Oliveira-Filho EC, Saito RM (1990) Chemical screening of Brazilian marine algae producing carrageenans. Hydrobiologia 204:585–588

    Google Scholar 

  • Oliveira-Filho EC, Saito RM, Santos NJ, Garófalo GM (1996) Temporal and spatial variation of agar from a population of Pterocladia capillacea (Gelidiales, Rhodophyta) from Brazil. Hydrobiologia 326/327:501–504

    Google Scholar 

  • Paiva AAO, Castro AJG, Nascimento MS, Will LS, Santos ND, Araújo RM, Rocha FA, Leite EL (2011) Antioxidant and anti-inflammatory effect of polysaccharides from Lobophora variegata on zymosan-induced arthritis in rats. Int Immunopharmacol 11:1241–1250

    PubMed  CAS  Google Scholar 

  • Pereira M, Benevides N, Melo M, Valente A, Melo F, Mourão P (2005) Structure and anticoagulant activity of a sulfated galactan from the red alga, Gelidium crinale. Is there a specific structural requirement for the anticoagulant action? Carbohydr Res 340:2015–2023

    PubMed  CAS  Google Scholar 

  • Pinto VPT, Debray H, Danuta DUS, Teixeira EH, Oliveira TM, Carneiro VA, Teixeira AH, Filho GC, Nagano CS, Nascimento KS et al (2009) Lectins from the red marine algal species Bryothamnion seaforthii and Bryothamnion triquetrum as tools to differentiate human colon carcinoma cells. Adv Pharmacol Sci 2009:862162

    PubMed  PubMed Central  Google Scholar 

  • Pinto AMV, Leite JPG, Ferreira WJ, Cavalcanti DN, Villaça RC, Giongo V, Teixeira VL, Paixão ICNP (2012) Marine natural seaweed products as potential antiviral drugs against bovine viral diarrhea virus. Rev Bras Farmacogn 22:813–817

    CAS  Google Scholar 

  • Plouguerné E, Cesconetto C, Cruz CP, Pereira RC, da Gama BAP (2012) Within-thallus variation in polyphenolic content and antifouling activity in Sargassum vulgare. J Appl Phycol 24:1629–1635

    Google Scholar 

  • Provost C, Escoffier C, Maamaatuaiahutapu K, Kartavtserf A, Garjon V (1999) Subtropical mode waters in the South Atlantic Ocean. J Geophys Res 104:21,033–21,049

    Google Scholar 

  • Queiroz KCS, Assis CF, Medeiros VP, Rocha HA, Aoyama H, Ferreira CV, Leite EL (2006) Cytotoxicity effect of algal polysaccharides on HL60 cells. Biochemistry 71:1312–1315

    PubMed  CAS  Google Scholar 

  • Queiroz KCS, Medeiros VP, Queiroz SL, Abreu LR, Rocha HA, Ferreira CV, Jucá MB, Aoyama H, Leite EL (2008) Inhibition of reverse transcriptase activity of HIV by polysaccharides of brown algae. Biomed Pharmacol 62:303–307

    CAS  Google Scholar 

  • Recalde MP, Noseda MD, Pujol CA, Carlucci MJ, Matulewicz MC (2008) Sulfated mannans from the red seaweed Nemalion helminthoides of the South Atlantic. Phytochemistry 70:1062–1068

    Google Scholar 

  • Reis RP, Loureiro RR, Mesquita FS (2011) Does salinity affect growth and carrageenan yield of Kappaphycus alvarezii (Gigartinales/Rhodophyta)? Aquacult Res 42:1231–1234

    Google Scholar 

  • Rocha HAO, Moraes FA, Trindade ES, Franco CR, Torquato RJ, Veiga SS, Valente AP, Mourão PA, Nader HB, Dietrich CP (2005) Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi: an ideal antithrombotic agent? J Biol Chem 280:41278–41288

    PubMed  CAS  Google Scholar 

  • Rocha FD, Soares AR, Houghton PJ, Pereira RC, Kaplan MA, Teixeira VL (2007) Potential cytotoxic activity from some Brazilian seaweeds on human melanoma cells. Phytother Res 21:170–175

    PubMed  Google Scholar 

  • Rocha OP, de Felício R, Rodrigues AHB, Ambrósio DL, Cicarelli RM, Albuquerque S, Young MC, Yokoya NS, Debonsi HM (2011) Chemical profile and biological potential of non-polar fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta). Molecules 16:7105–7114

    PubMed  CAS  Google Scholar 

  • Rodrigues JAG, Bezerra-Neto JTB, Pontes GC, Farias WRL (2009) Análise de metodologias na precipitação de polissacarídeos sulfatados extraídos da alga marinha verde Caulerpa racemosa (Forsskal) J. Agardh. Rev Bras Eng Pesca 4:32–43

    Google Scholar 

  • Rodrigues JAG, Vanderlei ESO, Quinderé ALG et al (2010) Avaliação do potencial anticoagulante de polissacarídeos sulfatados de macroalgas marinhas. Rev Bras Eng Pesca 5:56–69

    Google Scholar 

  • Rodrigues JAG, Vanderlei ESO, de Silva LMCM, Araújo IWF, de Queiroz INL, de Paula GA, Abreu TM, Ribeiro NA, Bezerra MM, Chaves HV, Lima V, Jorge RJB, Monteiro HSA, Leite EL, Benevides NMB (2012) Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the marine green alga Caulerpa cupressoides. Pharmacol Rep 64:282–292

    PubMed  CAS  Google Scholar 

  • Romanos MTV, Andrada-Serpa MJ, Mourão PAS, Yoneshighe-Valentin Y, Costa SS, Pereira MS, Miranda MMFS, Gonçalves JLS, Wigg MD (2002) A sulphated fucan from the Laminaria abyssalis marine algae inhibits the human T-cell lymphotropic virus type 1 (HTLV-1)- induced syncytium formation in hela cells. Antiviral Chem Chemother 13:219–221

    Google Scholar 

  • Sampaio AH, Rogers DJ, Barwell CJ (1996) Characterization of a new lectin from the green marine alga Ulva laetevirens. Lect Biol Biochem Clin Biochem 11:96–100

    Google Scholar 

  • Sampaio AH, Rogers DJ, Barwell CJ (1998a) A galactose-specific lectin from the red marine alga Ptilota filicina. Phytochemistry 48:765–769

    PubMed  CAS  Google Scholar 

  • Sampaio AH, Rogers DJ, Barwell CJ (1998b) Isolation and characterization of the lectin from the green marine alga Ulva lactuca Linnaeus. Bot Mar 41:427–433

    CAS  Google Scholar 

  • Sampaio AH, Rogers DJ, Barwell CJ, Saker-Sampaio S, Costa FHF, Ramos MV (1998c) A new isolation procedure and further characterization of the lectin from the red marine alga Ptilota serrata. J Appl Phycol 10:539–546

    CAS  Google Scholar 

  • Sampaio AH, Rogers DJ, Barwell CJ, Saker-Sampaio S, Nascimento KS, Nagano CS, Farias WRL (2002) New affinity procedure for the isolation and further characterization of the blood group B specific lectin from the red marine alga Ptilota plumosa. J Appl Phycol 14:489–495

    CAS  Google Scholar 

  • Santos MGM, Lagrota MHC, Miranda MMFS, Yoneshigue-Valentin Y, Wigg MD (1999) A screening for the antiviral effect of Brazilian marine alga extracts against acyclovir-resistant herpes simplex virus type 1. Bot Mar 42:227–230

    Google Scholar 

  • Santos CCC, Souza TML, Teixeira VL, Fontes CFL, Rebello MA, Branco LC, Abreu CM, Tanuri A, Frugulhetti ICPP, Bou-Habib DC (2008) The dolabellane diterpene Dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme. Antiviral Res 77:64–71

    Google Scholar 

  • Santos AO, Britta E, Bianco EM, Ueda-Nakamura T, Filho BP, Pereira RC, Nakamura CV (2011) 4-acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent. Mar Drugs 9:2369–2383

    PubMed  PubMed Central  Google Scholar 

  • Silva TMA, Alves LG, Queiroz KCS, Santos MGL, Marques CT, Chavante SF, Rocha HAO, Leite EL (2005) Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora. Braz J Med Biol Res 38:523–533

    PubMed  CAS  Google Scholar 

  • Silva LMCM, Lima V, Holanda ML, Pinheiro PG, Rodrigues JA, Lima ME, Benevides NM (2010) Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea. Biol Pharm Bull 33:830–835

    PubMed  CAS  Google Scholar 

  • Siqueira RCL, Silva MSJ, de Alencar DB, Pires Ade F, de Alencar NM, Prereira MG, Cavada BS, Sampaio AH, Farias WR, Assreuy AM (2011) In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata. Pharm Biol 49:167–174

    PubMed  CAS  Google Scholar 

  • Soares AR, Teixeira VL, Pereira RC, Villaça RC (2003) Variation on diterpene production by the Brazilian alga Stypopodium zonale (Dictyotales, Phaeophyta). Biochem Syst Ecol 31:1347–1350

    CAS  Google Scholar 

  • Soares AR, da Gama BAP, da Cunha AP, Teixeira VL, Pereira RC (2008) Induction of attachment of the mussel Perna perna by natural products from the brown alga Stypopodium zonale. Mar Biotechnol 10:158–165

    PubMed  CAS  Google Scholar 

  • Soares AR, Robaina M, Mendes GS, Silva TSL, Gestinari LMS, Pamplona OS, Yoneshigue-Valentin Y, Kaiser CR, Romanos MTV (2012a) Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus. Rev Bras Farmacogn 22:714–723

    CAS  Google Scholar 

  • Soares DC, Calegari-Silva TC, Lopes UG, Teixeira VL, Paixão ICNP, Cirne-Santos C, Bou-Habib DC, Saraiva EM (2012b) Dolabelladienetriol, a compound from Dictyota pfaffii algae, inhibits the infection by Leishmania amazonensis. PLoS Negl Trop Dis 6:e1787

    PubMed  CAS  PubMed Central  Google Scholar 

  • Sousa MB, Pires KMS, Alencar DB, Sampaio AH, Saker-Sampaio S (2008) Alfa- e beta-caroteno e alfa-tocoferol em algas marinhas in natura. Ciênc Technol Aliment 28:953–958

    Google Scholar 

  • Souza LAR, Azevedo TCG, Silva FRF, Cardoso ML et al (2007a) Caracterização química e ação farmacológica de polissacarídeos sulfatados extraídos da alga Amansia multifidea. Infarma 19:3–7

    Google Scholar 

  • Souza MCR, Marques CT, Dore CMPG, Silva FRF, Rocha HAO, Leite EL (2007b) Antioxidant activities of sulfated polysaccharides from brown and red seaweeds. J Appl Phycol 19:153–160

    Google Scholar 

  • Souza ET, Queiroz AC, Miranda GEC, Lorenzo VP, da Silva EF, Freire-Dias TLM, Cupertino-Silva YK, Melo GMA, Santos BVO, Chaves MCO, Alexandre-Moreira MS (2009) Antinociceptive activities of crude methanolic extract and phases, n-butanolic, chloroformic and ethyl acetate from Caulerpa racemosa (Caulerpaceae). Rev Bras Farmacogn 19:115–120

    Google Scholar 

  • Souza LAR, Dore CMPG, Castro AJG, Moura MFV, Benevides NMB, Leite EL (2012) Galactans from the red seaweed Amansia multifida and their effects on inflammation, angiogenesis, coagulation and cell viability. Biomed Prev Nutr 1:1–5

    Google Scholar 

  • Stein EM, Andreguetti DX, Rocha CS, Fujii MT, Baptista MS, Colepicolo P, Indig GL (2011a) Search for cytotoxic agents in multiple Laurencia complex seaweed species (Ceramiales, Rhodophyta) harvested from the Atlantic Ocean with emphasis on the Brazilian State of Espírito Santo. Rev Bras Farmacogn 21:239–243

    CAS  Google Scholar 

  • Stein EM, Colepicolo P, Afonso FAK, Fujii MT (2011b) Screening for antifungal activities of extracts of the Brazilian seaweed genus Laurencia (Ceramiales, Rhodophyta). Rev Bras Farmacogn 21:290–295

    Google Scholar 

  • Stevan FR, Oliveira MBM, Bucchi DF, Noseda MD, Iacomini M, Duarte ME (2001) Cytotoxic effect against HeLa cells of the seaweed polysaccharides. J Submicrosc Cytol Pathol 33:477–484

    PubMed  CAS  Google Scholar 

  • Stramma L, England M (1999) On the water masses and circulation of the South Atlantic Ocean. J Geophys Res 104:20,863–20,883

    Google Scholar 

  • Talarico LB, Pujol CA, Zibetti RGM, Faria PC, Noseda MD, Duarte ME, Damonte EP (2005) The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell. Antiviral Res 66:103–110

    PubMed  CAS  Google Scholar 

  • Talarico LB, Duarte MER, Zibetti RGM, Noseda MD, Damonte EB (2007) An algal-derived DL-galactan hybrid is an efficient preventing agent for in vitro dengue virus infection. Planta Med 73:1464–1468

    PubMed  CAS  Google Scholar 

  • Teixeira EH, Napimoga MH, Carneiro VA, De Oliveira TM, Nascimento KS, Nagano CS, Souza JB, Havt A, Pinto VPT, Gonçalves RB, Farias WRL, Saker-Sampaio S, Sampaio AH, Cavada BS (2007) In vitro inhibition of oral streptococci binding to the acquired pellicle by algal lectins. J Appl Microbiol 103:1001–1006

    PubMed  CAS  Google Scholar 

  • Teixeira VL, Santos CCC, Souza TML, Fontes CFL, Rebello MA, Branco LC, Abreu CM, Tanuri A, Frugulhetti ICPP, Bouhabib DC (2008) The dolabellane diterpene dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcripte. Antiviral Res 77:64–71

    Google Scholar 

  • Torres MR, Sousa APA, Silva-Filho EAT, Melo DF, Feitosa JPA, de Paula RCM, Lima MGS (2007) Extraction and physicochemical characterization of Sargassum vulgare alginate from Brazil. Carbohydr Res 342:2067–2074

    PubMed  CAS  Google Scholar 

  • Toyama MH, Toyama DO, Torres VM, Pontes GC, Farias WR, Melo FR, Oliveira SC, Fagundes FH, Diz Filho EB, Cavada BS (2010) Effects of low molecular weight sulfated galactan fragments from Botryocladia occidentalis on the pharmacological and enzymatic activity of Spla2 from Crotalus durissus cascavella. Protein J 29:567–571

    PubMed  CAS  Google Scholar 

  • Valentin JL (1984) Analyse des paramètres hydrobiologiques dans la remontée de Cabo Frio (Brésil). Mar Biol 82:259–276

    Google Scholar 

  • Vallim MA, Barbosa JE, Cavalcanti DN, De-Paula JC, da Silva VAGG, Teixeira VL, Paixão ICNP (2010) In vitro antiviral activity of diterpenes isolated from the Brazilian brown alga Canistrocarpus cervicornis. J Med Plant Res 4:2379–2382

    CAS  Google Scholar 

  • Vanderlei ESO, Araújo IWF, Quinderé ALG, Fontes BP, Eloy YRG, Rodrigues JAG, Silva AAR, Chaves HV, Jorge RJB, Menezes DB, Evangelista JSAM, Bezerra MM, Benevides NMB (2011) The involvement of the HO-1 pathway in the anti-inflammatory action of a sulfated polysaccharide isolated from the red seaweed Gracilaria birdiae. Inflamm Res 60:1121–1130

    CAS  Google Scholar 

  • Vasconcelos MA, Ferreira WJ, Pereira RC, Cavalcanti DN, Teixeira VL (2010) Chemical constituents from the red alga Plocamium brasiliense (Greville) M. Howe and W.R. Taylor. Biochem Syst Ecol 38:119–121

    CAS  Google Scholar 

  • Viana GSB, Freitas ALP, Lima MML, Vieira LAP, Andrade MCH, Benevides NMB (2002) Antinociceptive activity of sulfated carbohydrates from the red algae Bryothamnion seaforthii (Turner) Kütz. and B. triquetrum (S.G. Gmel.) M. Howe. Braz J Med Biol Res 35:713–722

    PubMed  CAS  Google Scholar 

  • Viana AG, Yokoya NS, Noseda MD, Gonçalves AG, Duarte MER, Matulewicz MC, Cerezo AS (2011) β-D-(1 → 4), β-D-(1 → 3) ‘mixed linkage’ xylans from red seaweeds of the order Nemaliales and Palmariales. Carbohydr Res 346:1023–1028

    PubMed  CAS  Google Scholar 

  • Vieira FP, Caland-Noronha MC (1971) Atividade antibiótica de algumas algas marinhas do estado do Ceará. Arq Cienc Mar 11:91–93

    Google Scholar 

  • Vieira LAP, Freitas ALP, Feitosa JPA, Viana GSB (2004) The alga Bryothamnion seaforthii contains carbohydrates with antinociceptive activity. Braz J Med Biol Res 37:1071–1079

    PubMed  CAS  Google Scholar 

  • Yoneshigue-Valentin Y, Gestinari LMS, Fernandes DRP (2006) Macroalgas. In: Lavrado HP, Ignacio BL (eds) Biodiversidade bentônica da região central da Zona Econômica Exclusiva Brasileira (Série Livros n. 18). Museu Nacional, Rio de Janeiro, pp 67–105

    Google Scholar 

  • Zibetti RGM, Duarte MER, Noseda MD, Colodi FG, Ducatti DRB, Ferreira LG, Cardoso MA, Cerezo AS (2009) Galactans from Cryptonemia species. Part II: studies on the system of galactans of Cryptonemia seminervis (Halymeniales) and on the structure of major fractions. Carbohydr Res 344:2364–2374

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Dr. Janet W. Reid and Dr. Eduardo G.P. Fox for their critical review of this manuscript. Financial support was provided by a postdoctoral grant from the Brazilian National Council of Technological and Scientific Development, CNPq (150216/2013-0–DRPF; 560420/2010-2–VPO); and the Carlos Chagas Filho Research Support Foundation, FAPERJ (PVE: E-26/102.757/2011-YYV).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniela Rezende Peçanha Fernandes.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Online Resource 1

(XLSX 121 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fernandes, D.R.P., de Oliveira, V.P. & Yoneshigue Valentin, Y. Seaweed biotechnology in Brazil: six decades of studies on natural products and their antibiotic and other biological activities. J Appl Phycol 26, 1923–1937 (2014). https://doi.org/10.1007/s10811-014-0287-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10811-014-0287-5

Keywords

Navigation