Skip to main content
SpringerLink
Log in

A simple and sensitive electroanalytical determination of anxiolytic buspirone hydrochloride drug based on multiwalled carbon nanotubes modified electrode

  • Research Article
  • Published:
Journal of Applied Electrochemistry Aims and scope Submit manuscript

Abstract

In the present study, a simple and sensitive buspirone hydrochloride (BPH) sensor was developed based on multiwalled carbon nanotubes (MWCNT) modified electrode. The modified electrode was characterized using transmission electron microscopy and electrochemical impedance spectroscopy. The MWCNT modified electrode showed an enhanced oxidation peak current response toward BPH than unmodified electrode. The oxidation peak potential of BPH at modified electrode was 0.85, which was quite lower than that of bare electrode (0.88 V). The BPH was successfully determined at modified electrode using different electrochemical methods, such as cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometry. The good sensitivity and linear range response of BPH were obtained using amperometry when compared with other methods employed in this study (CV and DPV). The modified electrode displayed the electro-oxidation of BPH in the linear response from 0.5 to 99.5 μM with the sensitivity of 16.49 μA μM−1 cm−2. The limit of detection was calculated as 0.22 μM. In addition, the modified electrode exhibited a good repeatability and repeatability with acceptable stability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Dommisse CS, Vane CLD (1985) Buspirone: a new type of anxiolytic. Intell Clin Pharm 19:624–628

    CAS  Google Scholar 

  2. Parfitt K, Sweetman SC, Blake PS, Parsons AV, Martindale (1999) The Extra Pharmacopoeia. Pharmaceutical Press, London

    Google Scholar 

  3. Odontiadis J, Franklin M (1996) Simultaneous quantitation of buspirone and its major metabolite 1-(2-pyrimidinyl) piperazine in human plasma by high-performance liquid chromatography with coulometric detection. J Pharm Biomed Anal 14:347–351

    Article  CAS  Google Scholar 

  4. Gupta VK, Jain R, Radhapyari K, Jadon N, Agarwal S (2011) Voltammetric techniques for the assay of pharmaceuticals—a review. Anal Biochem 408:179–196

    Article  CAS  Google Scholar 

  5. Jain R, Rani S, Goyal RN (1981) Polarographic behaviour of some potential antidiabetic benzylsulphonylarylazopyrazoles. Electrochim Acta 26:1519–1523

    Article  CAS  Google Scholar 

  6. Riekes MK, Pereira RN, Rauber GS, Cuffini SL, Campos CEM, Silva MAS, Stulzer HK (2012) Polymorphism in nimodipine raw materials: development and validation of a quantitative method through differential scanning calorimetry. J Pharm Biomed Anal 70:188–193

    Article  CAS  Google Scholar 

  7. Sheikhzadeh M, Rohani S, Taffish M, Murad S (2007) Solubility analysis of buspirone hydrochloride polymorphs: measurements and prediction. Int J Pharm 338:55–63

    Article  CAS  Google Scholar 

  8. Gao W, Song J, Wu N (2005) Voltammetric behavior and square-wave voltammetric determination of trepibutone at a pencil graphite electrode. J Electroanal Chem 576:1–7

    Article  CAS  Google Scholar 

  9. Unnikrishnan B, Mani V, Chen SM (2012) Highly sensitive amperometric sensor for carbamazepine determination based on electrochemically reduced graphene oxide–single-walled carbon nanotube composite film. Sens Actuators 173:274–280

    Article  CAS  Google Scholar 

  10. Cheemalapati S, Palanisamy S, Chen SM (2012) Electrochemical determination of hydralazine hydrochloride by preanodised screen printed carbon electrode. Int J Electrochem Sci 7:11488–11496

    CAS  Google Scholar 

  11. Xi X, Ming L (2012) A voltammetric sensor based on electrochemically reduced graphene modified electrode for sensitive determination of midecamycin. Anal Methods 4:3013–3018

    Article  CAS  Google Scholar 

  12. Wang J (2005) Carbon-nanotube based electrochemical biosensors: a review. Electroanalysis 17:7–14

    Article  CAS  Google Scholar 

  13. Jacobs CB, Peairs MJ, Venton BJ (2010) Review: carbon nanotube based electrochemical sensors for biomolecules. Anal Chim Acta 662:105–127

    Article  CAS  Google Scholar 

  14. Zarei H, Ghourchian H, Eskandari K, Zeinali M (2012) Magnetic nanocomposite of anti-human IgG/COOH–multiwalled carbon nanotubes/Fe3O4 as a platform for electrochemical immunoassay. Anal Biochem 421:446–453

    Article  CAS  Google Scholar 

  15. Chng ELK, Pumera M (2011) Nanographitic impurities are responsible for electrocatalytic activity of carbon nanotubes towards oxidation of carbamazepine. Electrochem Commun 13(8):781–784

    Article  CAS  Google Scholar 

  16. Jacobs CB, Peairs MJ, Venton BJ (2010) Review: carbon nanotube based electrochemical sensors for biomolecules. Anal Chim Acta 662:105–127

    Article  CAS  Google Scholar 

  17. Zarei H, Ghourchian H, Eskandari K, Zeinali M (2012) Magnetic nanocomposite of anti-human IgG/COOH–multiwalled carbon nanotubes/Fe3O4 as a platform for electrochemical immunoassay. Anal Biochem 421:446–453

    Article  CAS  Google Scholar 

  18. Chng ELK, Pumera M (2011) Nanographitic impurities are responsible for electrocatalytic activity of carbon nanotubes towards oxidation of carbamazepine. Electrochem Commun 13:781–784

    Article  CAS  Google Scholar 

  19. Parandis D, Nazanin G, Akbar MMA, Mehdi RS, Parviz N, Faizan A, Reza GM (2012) Nanosilver-DNA hybrid modified electrode for electrochemical sensing of buspirone in biological samples and pharmaceutical preparation. Sensor Lett 10:814–819

    Article  Google Scholar 

  20. Chen SZ, Xu F, Zhang H, Zhang ZQ (1993) Voltammetric determination of buspirone. Talanta 40:1551–1555

    Article  CAS  Google Scholar 

  21. Amanlou M, Keivani S, Sadri B, Dadras OG, Souri E (2009) Simple extractive colorimetric determination of buspirone by acid-dye complexation method in solid dosage form. Research in Pharmaceutical Sciences 4:11–18

    CAS  Google Scholar 

  22. Foroutan SM, Zarghi A, Shafaati AR, Khoddam A (2004) Simple high-performance liquid chromatographic determination of buspirone in human plasma. IL FARMACO 59:739–742

    Article  CAS  Google Scholar 

  23. Sabry SM, Barary MH, Hay MHA, Belal TS (2004) Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs. J Pharm Biomed Anal 34:509–516

    Article  CAS  Google Scholar 

  24. Green R, Houghton R, Jacobs S (2004) Determination of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in human plasma by liquid chromatography tandem mass spectrometry. Chromatographia 59:S197–S201

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study was supported by the National Science Council and the Ministry of Education of Taiwan (Republic of China).

Author information

Authors and Affiliations

  1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan (ROC)

    Srikanth Cheemalapati, Selvakumar Palanisamy & Shen-Ming Chen

Authors
  1. Srikanth Cheemalapati
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Selvakumar Palanisamy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shen-Ming Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shen-Ming Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cheemalapati, S., Palanisamy, S. & Chen, SM. A simple and sensitive electroanalytical determination of anxiolytic buspirone hydrochloride drug based on multiwalled carbon nanotubes modified electrode. J Appl Electrochem 44, 317–323 (2014). https://doi.org/10.1007/s10800-013-0637-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10800-013-0637-z

Keywords

Search

Navigation