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Effects of injectable platelet-rich fibrin (i-PRF) on pterygium surgery with conjunctival autograft

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Abstract

Objectives

To investigate the effects of subconjunctival injectable platelet-rich fibrin (i-PRF) injection on healing and complication rates after pterygium surgery with conjunctival autograft.

Methods

This retrospective and comparative study evaluated 31 eyes that received i-PRF injections under the donor and graft conjunctiva following pterygium surgery, while 34 eyes did not receive i-PRF after the pterygium surgery. The patients’ follow-up period was for 12 months. Postoperative recurrence, epithelial healing time, postoperative pain score, graft edema, and sliding of the graft (need for re-suturation) data were evaluated.

Results

For the 12 months after surgery, one eye (3.2%) in the i-PRF group had developed corneal recurrence, and five eyes (14.7%) in the non-i-PRF group had developed recurrence. The mean corneal epithelial healing time was 2.96 ± 0.70 days in the i-PRF group and 3.58 ± 0.70 days in the non-i-PRF group (p = 0.001). The mean healing time of the donor conjunctiva epithelium was 3.84 ± 0.70 days in the i-PRF group, whereas it was 4.44 ± 0.74 days in the non-i-PRF group (p = 0.006). The mean postoperative pain score was 4.45 ± 1.52 in the i-PRF group and 5.08 ± 1.40 in the non-i-PRF group. In the non-i-PRF group, three cases (8.8%) required re-suturation, whereas, in the i-PRF group, no one required re-suturation.

Conclusions

Thanks to its platelets-derived growth factors, i-PRF can be a safe and effective adjuvant therapy for faster healing of conjunctival autograft and in the prevention of recurrence.

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Funding

Authors declare that they did not receive any financial support in this study.

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Authors and Affiliations

  1. Department of Ophtalmology, Diskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

    Alperen Bahar & Huri Sabur

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  1. Alperen Bahar
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  2. Huri Sabur
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Contributions

All authors contributed to the study’s conception and design. Material preparation, data collection, and analysis were performed by AB and HS. The first draft of the manuscript was written by AB, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Alperen Bahar.

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Bahar, A., Sabur, H. Effects of injectable platelet-rich fibrin (i-PRF) on pterygium surgery with conjunctival autograft. Int Ophthalmol 44, 65 (2024). https://doi.org/10.1007/s10792-024-02920-5

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