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The relationship of tear osmolarity with tear meniscus curvature and contact angles in healthy subjects: anterior segment optical coherence tomography study

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Abstract

Purpose

To evaluate the relationship of tear osmolarity (TO) with tear meniscus curvature and contact angles by anterior segment optical coherence tomography (AS-OCT) in healthy subjects.

Methods

The right eyes of 64 consecutive healthy subjects were included in the study. The eyes were scanned by AS-OCT for the measurements of upper and lower tear menisci. The geometrical components of the upper and lower menisci, including height, depth, area, and radius of the menisci, cornea-meniscus angle (α-angle), meniscus-eyelid angle (β-angle), and curvature angle (θ-angle) were measured. TO was obtained by TearLab. All participants were administered Ocular Surface Disease Index questionnaires (OSDI), and tear film break-up time (TBUT), Schirmer I and II test measurements were also performed.

Results

There was no association of TO with height, depth, and area of both menisci while TO was negatively correlated to θ-angle and radius of the lower eyelid meniscus (r = − 0.41, P < 0.001 and r = − 0.40, P < 0.01, respectively). The θ-angle and the radius of the lower meniscus were also significantly associated with OSDI score, TBUT, Schirmer I and II (P < 0.01 for all). There was a statistically strong correlation between the θ-angle and the radius of the lower meniscus (r = 0.91, P < 0.001).

Conclusion

The curvature angle and radius of the lower meniscus are significantly associated with TO. The curvature angle of the lower meniscus is a useful non-contact measure that may provide information indirectly about the osmolarity and the quality of the tear.

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Authors and Affiliations

  1. Department of Ophthalmology, Ondokuz Mayıs University, 55139, Samsun, Turkey

    Volkan Yeter, Nurullah Koçak, Merve Kalyoncu, Ertuğrul Can & Nurşen Arıtürk

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  1. Volkan Yeter
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  2. Nurullah Koçak
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  3. Merve Kalyoncu
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  4. Ertuğrul Can
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  5. Nurşen Arıtürk
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Correspondence to Volkan Yeter.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 declaration of HELSINKI and its later amendments or comparable ethical standards.

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Yeter, V., Koçak, N., Kalyoncu, M. et al. The relationship of tear osmolarity with tear meniscus curvature and contact angles in healthy subjects: anterior segment optical coherence tomography study. Int Ophthalmol 42, 261–268 (2022). https://doi.org/10.1007/s10792-021-02022-6

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