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Vogt-Koyanagi-Harada disease in a Native American population in Oklahoma

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Abstract

Purpose

To describe the presentation, features, and outcomes of patients with Vogt-Koyanagi-Harada disease (VKH) seen by uveitis specialists in Oklahoma.

Methods

Clinical data were collected for 26 patients (52 eyes) diagnosed with VKH and seen between 1992 and 2018. Main outcome measures included rates of visual loss, ocular complications, and remission.

Results

There were 11 Native American (NA) patients (11/26, 42.3%) and 15 non-Natives (n-NA). NA VKH patients were significantly more likely to present at a younger age (18.6 years) than n-NA VKH patients (30.1 years) (p = 0.023). NA patients were less likely to have meningismus (0.00 vs. 42.9%; 0.048) or systemic symptoms (50.0% vs. 93.3%; p = 0.023) than n-NA patients, but more likely to develop cataracts (100.0% vs. 66.7%; p = 0.003). There were similar rates of macular edema, epiretinal membrane, subretinal fibrosis, and recurrent uveitis between the two groups. Oral corticosteroid use was similar between both groups (72.7% vs. 86.7%; p = 0.61).

Conclusions

VKH may manifest with earlier disease course in NA patients than n-NA patients, particularly regarding ocular findings. However, NA patients were less likely to have systemic symptoms than n-NA patients.

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Funding

Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Texas Health Science Center, 5282 Medical Drive #610, San Antonio, TX, 78229, USA

    Ashvini K. Reddy

  2. Athena Eye Institute, San Antonio, TX, USA

    Ashvini K. Reddy

  3. Department of Ophthalmology, Oklahoma University Health Science Center, Oklahoma City, OK, USA

    Finny T. John

  4. Dean McGee Eye Institute, Oklahoma City, OK, USA

    Finny T. John

  5. Department of Surgery, Uniformed Services University of the Health Science, Bethesda, MD, USA

    Grant A. Justin

  6. Department of Ophthalmology, Brooke Army Medical Center, San Antonio, TX, USA

    Grant A. Justin

  7. Retina Center of Oklahoma, Oklahoma City, OK, USA

    Sami S. Dahr

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  1. Ashvini K. Reddy
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Corresponding author

Correspondence to Ashvini K. Reddy.

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The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., the US Army Medical Department, the US Army Office of the Surgeon General, the Department of the Air Force, the Department of the Army, Department of Defense, the Uniformed Services University of the Health Sciences or any other agency of the US Government. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government.

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Reddy, A.K., John, F.T., Justin, G.A. et al. Vogt-Koyanagi-Harada disease in a Native American population in Oklahoma. Int Ophthalmol 41, 915–922 (2021). https://doi.org/10.1007/s10792-020-01647-3

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  • DOI: https://doi.org/10.1007/s10792-020-01647-3

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Article history

  1. Latest

    Vogt-Koyanagi-Harada disease in a Native American population in Oklahoma
    • Ashvini K. Reddy
    • Finny T. John
    • Grant A. Justin
    • Sami S. Dahr
    Published:
    01 March 2021
    Received:
    04 August 2020
    Accepted:
    29 October 2020

    DOI: https://doi.org/10.1007/s10792-020-01647-3