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Effect of brimonidine tartrate 0.2% ophthalmic solution on visual quality after implantable collamer lens implantation with a central hole

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Abstract

Purpose

To investigate the effect of brimonidine tartrate 0.2% on visual quality after implantable collamer lens with a central hole (ICL V4c).

Methods

This study comprised 59 consecutive patients implanted with an ICL V4c. Brimonidine was administered randomly into one eye of the patients with symptomatic glare or halos 1 week postoperatively and the contralateral eye with artificial tears as the control group. Visual quality (measured by a optical quality analysis system), pupil size and refraction under scotopic light conditions were measured before and 0.5, 1.5, 3 and 6 h after administration of brimonidine. A symptom questionnaire was also evaluated.

Results

The visual quality improved and reached its maximum value, and the scotopic pupil size reached its minimum value 1.5 h after brimonidine administration, with a statistically significant difference seen from 0.5 to 3 h compared to baseline. No changes in refraction were seen after brimonidine. The questionnaire showed that symptoms of glare or halos could be eliminated after brimonidine in 58% of patients, be alleviated in 37% of patients and be unchanged in 5% of patient. However, 10% of patients experienced conjunctival congestion and some patients experienced reduced drug efficacy 1 month after treatment.

Conclusion

Brimonidine can be used to improve night visual quality in early postoperative period after ICL V4c implantation. It helps patients to quickly adapt to the glare or halos.

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Funding

This work was supported by the Shanghai Shenkang Hospital Development Center (Grant No. SHDC12016207) and the Shanghai Science and Technology Commission (Grant No. 19140900700).

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Authors and Affiliations

  1. Department of Ophthalmology, Eye and ENT Hospital of Fudan University, No. 19 BaoQing Road, Shanghai, 200031, People’s Republic of China

    Xun Chen, Xiaoying Wang, Yishan Qian, Huamao Miao & Xingtao Zhou

  2. Myopia Key Laboratory of the Health Ministry, No. 19 BaoQing Road, Shanghai, 200031, People’s Republic of China

    Xun Chen, Xiaoying Wang, Yishan Qian, Huamao Miao & Xingtao Zhou

  3. Research Center of Ophthalmology and Optometry, Shanghai, People’s Republic of China

    Xun Chen, Xiaoying Wang, Yishan Qian, Huamao Miao & Xingtao Zhou

  4. School of Medicine, The University of Sydney, Camperdown, NSW, Australia

    Rajeev Krishnan Naidu

Authors
  1. Xun Chen
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  2. Xiaoying Wang
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  3. Rajeev Krishnan Naidu
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  4. Yishan Qian
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  5. Huamao Miao
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Corresponding author

Correspondence to Xiaoying Wang.

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No author has a financial or proprietary interest in any material or method.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Chen, X., Wang, X., Naidu, R.K. et al. Effect of brimonidine tartrate 0.2% ophthalmic solution on visual quality after implantable collamer lens implantation with a central hole. Int Ophthalmol 41, 293–301 (2021). https://doi.org/10.1007/s10792-020-01581-4

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  • DOI: https://doi.org/10.1007/s10792-020-01581-4

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