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Anti-inflammatory effect of Acacia visco extracts in animal models

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Abstract

The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A2-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities.

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Abbreviations

Phospholipase A2 :

PLA2

AvInL:

Acacia visco leaves infusion

AvInB:

Acacia visco bark infusion

AvMeL:

Acacia visco leaves methanolic extract

AvMeB:

Acacia visco bark methanolic extract

AvHeL:

Acacia visco leaves hexane extract

AvChL:

Acacia visco leaves chloroform extract

DPPH:

1,1-Diphenyl-2-picrylhydrazyl

IC50 :

Inhibitory concentration 50

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Acknowledgments

This work was supported by National University of San Luis, Science and Technique (CYT), Project No. 22/Q604. The authors thank Dr. Carlos E. Ardanaz for his assistance in the discussion of mass spectral data and valuable comments.

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Authors and Affiliations

  1. Laboratorio de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis, Argentina

    Ana María Pedernera, Teresita Guardia, Alejandra Ester Rotelli, Nadir Ernesto de la Rocha, Susana Garcia Aseff & Lilian Eugenia Pelzer

  2. Laboratorio de Bromatología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis, Argentina

    Carola Elisa Guardia Calderón

  3. INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis, Argentina

    José Roberto Saad & María Alejandra Lopez Verrilli

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  1. Ana María Pedernera
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  2. Teresita Guardia
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Correspondence to Teresita Guardia.

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Pedernera, A.M., Guardia, T., Guardia Calderón, C.E. et al. Anti-inflammatory effect of Acacia visco extracts in animal models. Inflammopharmacol 18, 253–260 (2010). https://doi.org/10.1007/s10787-009-0028-6

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