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Non-invasive Glucose Measurements Using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR)

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Abstract

Wavelength-modulated differential laser photothermal radiometry (WM-DPTR) is introduced for potential development of clinically viable non-invasive glucose biosensors. WM-DPTR features unprecedented glucose-specificity and sensitivity by combining laser excitation by two out-of-phase modulated beams at wavelengths near the peak and the baseline of a prominent and isolated mid-IR glucose absorption band. Measurements on water–glucose phantoms (0 to 300 mg/dl glucose concentration) demonstrate high sensitivity to meet wide clinical detection requirements ranging from hypoglycemia to hyperglycemia. The measurement results have been validated by simulations based on fully developed WM-DPTR theory. For sensitive and accurate glucose measurements, the key is the selection and tight control of the intensity ratio and the phase shift of the two laser beams.

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Authors and Affiliations

  1. Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, 5 King’s College Road, Toronto, ON, M5S 3G8, Canada

    X. Guo & A. Mandelis

  2. Mount Sinai Hospital, Samuel Lunenfeld Research Institute, University of Toronto, 60 Murray Street, Toronto, ON, M5T 3L9, Canada

    B. Zinman

Authors
  1. X. Guo
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  2. A. Mandelis
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  3. B. Zinman
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Correspondence to X. Guo.

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Guo, X., Mandelis, A. & Zinman, B. Non-invasive Glucose Measurements Using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR). Int J Thermophys 33, 1814–1821 (2012). https://doi.org/10.1007/s10765-012-1276-z

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  • DOI: https://doi.org/10.1007/s10765-012-1276-z

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