Skip to main content
Log in

Electrospinning synthesis and characterization of PLA-PEG-MNPs composite fibrous membranes

  • Published:
Hyperfine Interactions Aims and scope Submit manuscript

Abstract

An electrospinning technique was used to fabricate PLA, PLA-PEG and PLA-PEG-MNPs composite fibrous membranes. The morphology of electrospun composite membranes were characterized by scanning electron microscope. To test the potential availability of MNPs in PLA-PEG composite membranes, TG, Raman, Mössbauer, VSM and ICP-OES analysis were used. The PLA-PEG composite fibrous membranes showed the presence of MNPs, hence offers the possibility for magnetically triggered on-demand drug delivery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zeng, J., et al.: Biodegradable electrospun fibers for drug delivery. J. Control. Release 92(3), 227–231 (2003)

    Article  Google Scholar 

  2. Edelman, E.R., Langer, R.: Optimization of release from magnetically controlled polymeric drug release devices. Biomaterials 14(8), 621–626 (1993)

    Article  Google Scholar 

  3. Andrä, W., Nowak, H.: Magnetism in Medicine. Wiley-VCH Verlag GmbH & Co KGaA, Weinheim (2007)

    Google Scholar 

  4. Yellen, B.B., et al.: Targeted drug delivery to magnetic implants for therapeutic applications. J. Magn. Magn. Mater. 293(1), 647–654 (2005)

    Article  ADS  Google Scholar 

  5. Iannone, A., et al.: Blood clearance of dextran magnetite particles determined by a noninvasive in vivo ESR method. Magn. Reson. Med. 22(2), 435–442 (1991)

    Article  Google Scholar 

  6. Hilger, I., Frühauf, K., Andrä, W., Hiergeist, R., Hergt, R., Kaiser, W.A.: Heating potential of iron oxides for therapeutic purposes in interventional radiology. Acad. Radiol. 9(2), 198–202 (2002)

    Article  Google Scholar 

  7. Thévenot, J., Oliveira, H., Sandre, O., Lecommandoux, S.: Magnetic responsive polymer composite materials. Chem. Soc. Rev. 42(17), 7099 (2013)

    Article  Google Scholar 

  8. Fernandez-Pacheco, R., et al.: Magnetic nanoparticles for local drug delivery using magnetic implants. J. Magn. Magn. Mater. 311(1 Spec. Iss.), 318–322 (2007)

    Article  ADS  Google Scholar 

  9. Landfester, K., Ram rez, L.P.: Encapsulated magnetite particles for biomedical application. J. Phys. Condens. Matter 15(15), S1345–S1361 (2003)

    Article  Google Scholar 

  10. Lasprilla, A.J.R., Martinez, G.A.R., Lunelli, B.H., Jardini, A.L., Filho, R.M.: Poly-lactic acid synthesis for application in biomedical devices—a review. Biotechnol. Adv. 30(1), 321–328 (2012)

    Article  Google Scholar 

  11. Chaiwong, C., Rachtanapun, P., Wongchaiya, P., Auras, R., Boonyawan, D.: Effect of plasma treatment on hydrophobicity and barrier property of polylactic acid. Surf. Coatings Technol. 204(18–19), 2933–2939 (2010)

    Article  Google Scholar 

  12. Sheth, M., Kumar, R.A., Dave, V., Gross, A.R., McCarthy, P.S.: Biodegradable polymer blends of poly (lactic acid) and poly (ethylene glycol). J. Appl. Polym. Sci. 66, 1495–1505 (1996)

    Article  Google Scholar 

  13. Ferreira, R.V., et al.: Synthesis and characterization of silica-coated nanoparticles of magnetite. Hyperfine Interact. 195(1), 265–274 (2009)

    ADS  Google Scholar 

  14. Kumar, M., Unruh, D., Sindelar, R., Renz, F.: Preparation of magnetic polylactic acid fiber mats by electrospinning. Nano Hybrids Compos. 14, 39–47 (2017)

    Article  Google Scholar 

  15. Bognitzki, M., et al.: Nanostructured fibers via electrospinning. Adv. Mater. 13, 70–72 (2001)

    Article  Google Scholar 

  16. Toncheva, A., et al.: Antibacterial PLA/PEG electrospun fibers: comparative study between grafting and blending PEG. Eur. Polym. J. 75, 223–233 (2016)

    Article  Google Scholar 

  17. Kumar, M., et al.: Mixture of PLA-PEG and biotinylated albumin enables immobilization of avidins on electrospun fibers. J. Biomed. Mater. Res. - Part A 105A, 356–362 (2017)

    Article  Google Scholar 

  18. Kister, G., Cassanas, G., Vert, M., Pauvert, B., Tébol, A.: Vibrational analysis of poly(L-lactic acid). J. RAMAN Spectrosc. 26, 307–311 (1995)

    Article  ADS  Google Scholar 

  19. Kister, G., Cassanas, G., Vert, M.: Effects of morphology, conformation and configuration on the IR and Raman spectra of various poly(lactic acid)s. Polymer (Guildf). 39(2), 267–273 (1998)

    Article  Google Scholar 

  20. Meyer, T., et al.: Electrospun complexes—functionalised nanofibres. Hyperfine Interact. 237(1), 1–11 (2016)

    Article  ADS  MathSciNet  Google Scholar 

  21. Pan, W., Han, R., Chi, X., Liu, Q., Wang, J.: Ferromagnetic Fe3O4 nanofibers: electrospinning synthesis and characterization. J. Alloys Compd. 577(3), 192–194 (2013)

    Article  Google Scholar 

  22. Mahmed, N., Heczko, O., Lancok, A., Hannula, S.P.: The magnetic and oxidation behavior of bare and silica-coated iron oxide nanoparticles synthesized by reverse co-precipitation of ferrous ion (Fe 2+ ) in ambient atmosphere. J. Magn. Magn. Mater. 353, 15–22 (2014)

    Article  ADS  Google Scholar 

  23. Cullity, B.D., Graham, C.D.: Introduction to Magnetic Materials. Wiley, New York (2009)

    Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge Hannover School for Nanotechnology, Germany for their financial supports. We would like to thank M.Sc. Fabian Zimmermann, Institut für Analytical Chemistry, LUH, Hannover for access and assistance to Raman and ICP-OES analysis and Dr.-Ing. Marc Christopher Wurz, Institut für Mikroproduktionstechnik, LUH, Hannover for VSM.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Renz.

Additional information

This article is part of the Topical Collection on Proceedings of the 3rd Mediterranean Conference on the Applications of the Mössbauer Effect (MECAME 2017), Jerusalem, Israel, 5–7 June 2017

Edited by Mira Ristic, Stjepko Krehula, Israel Nowik and Israel Felner

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, M., Klimke, S., Preiss, A. et al. Electrospinning synthesis and characterization of PLA-PEG-MNPs composite fibrous membranes. Hyperfine Interact 238, 66 (2017). https://doi.org/10.1007/s10751-017-1435-5

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s10751-017-1435-5

Keywords

Navigation