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Current views on anthracycline cardiotoxicity

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Abstract

Anthracyclines are well established and effective anticancer agents used to treat a variety of adult and pediatric cancers. Unfortunately, these drugs are also among the commonest chemotherapeutic agents that have been recognized to cause cardiotoxicity. In the last years, several experimental and clinical investigations provided new information and perspectives on anthracycline-related cardiotoxicity. In particular, molecular mechanisms of cardiotoxicity have been better elucidated, early diagnosis has improved through the use of advanced noninvasive cardiac imaging techniques, and emerging data indicate a genetic predisposition to develop anthracycline-related cardiotoxicity. In this article, we review established and new knowledge about anthracycline cardiotoxicity, with special focus on recent advances in cardiotoxicity diagnosis and genetic profiling.

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Authors and Affiliations

  1. Cardiology Unit, Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy

    Donato Mele, Marianna Nardozza, Michele Malagù & Roberto Ferrari

  2. Maria Cecilia Hospital, GVM Care and Research, E.S: Health Science Foundation, Cotignola, Italy

    Donato Mele, Marianna Nardozza, Michele Malagù & Roberto Ferrari

  3. Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy

    Paolo Spallarossa

  4. Oncology Unit, University Hospital of Ferrara, Ferrara, Italy

    Antonio Frassoldati

  5. Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy

    Carlo G. Tocchetti

  6. Department of Medical Sciences “Mario Aresu”, University of Cagliari, Cagliari, Italy

    Christian Cadeddu & Giuseppe Mercuro

  7. Department of Cardiology, Center of Excellence on Aging, “G. d’Annunzio” University, Chieti, Italy

    Rosalinda Madonna

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  1. Donato Mele
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  2. Marianna Nardozza
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  3. Paolo Spallarossa
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  5. Carlo G. Tocchetti
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  7. Rosalinda Madonna
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  8. Michele Malagù
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  9. Roberto Ferrari
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Correspondence to Donato Mele.

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On behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.

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Mele, D., Nardozza, M., Spallarossa, P. et al. Current views on anthracycline cardiotoxicity. Heart Fail Rev 21, 621–634 (2016). https://doi.org/10.1007/s10741-016-9564-5

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