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Thyroid hormones and cardiac remodeling

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Abstract

Thyroid hormones have many cardioprotective actions expressed mainly through the action of T3 on thyroid receptors α1 and β1. They are procontractile anti-apoptotic, anti-inflammatory, and anti-fibrotic, promote angiogenesis and regeneration, and have beneficial effects on microRNA profiles. They have proven to be anti-remodeling in numerous animal studies, mostly in rodents; a specific action on the border zone has been described. Studies in humans with DIPTA have been in conclusion. Remodeling can be defined as an increase of ≥20 % of the end-diastolic or end-systolic volume, together with a return to the fetal phenotype. An overview of animal and clinical studies is given.

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  1. Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27, Athens, Greece

    Dennis V. Cokkinos & Stavros Chryssanthopoulos

  2. Onassis Cardiac Surgery Center Athens, Athens, Greece

    Dennis V. Cokkinos

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  1. Dennis V. Cokkinos
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Cokkinos, D.V., Chryssanthopoulos, S. Thyroid hormones and cardiac remodeling. Heart Fail Rev 21, 365–372 (2016). https://doi.org/10.1007/s10741-016-9554-7

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