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Is there an association between invasive lobular carcinoma of the breast and a family history of gastric cancer?

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Abstract

CDH1 gene mutations have been found to be associated with diffuse type gastric cancer and invasive lobular carcinoma (ILC) of the breast. To the best of our knowledge, this is the only study relating a family history of gastric cancer to ILC of the breast. We conducted a retrospective study comparing the family history of malignancies in patients with invasive ductal carcinoma (IDC) of the breast and ILC treated in our Medical Center. The comparison was evaluated in both types of breast cancer groups, dividing the patients into two age groups, <50 and ≥50 years. One thousand one hundred and sixty-seven patients with IDC and ILC entered the study. A family history of malignancies was reported in 21.6 % of patients with IDC as opposed to 37.8 % of patients with ILC (P < 0.001). A history of gastric cancer was reported in 7.2 % in the ILC group as compared to 2.3 % in the IDC group, P < 0.008. A family history of breast cancer was more common in the ILC group as opposed to the IDC group, 18 versus 8.1 % respectively, P = 0.002 and persisted in both age groups. We conclude that a family history of malignancies in first degree relatives is more common in patients with ILC than IDC and that there is a significant association between a family history of gastric cancer and ILC.

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Acknowledgments

The authors have no commercial associations, financial disclosures, or other conflicts of interest to report with regard to this article. There are no sources of support for the work in the form of grants, equipment, drugs, or any combination of these.

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Authors and Affiliations

  1. Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel

    Bar Chikman, Hasan Kais, Igor Jeroukhimov, Ariel Halevy & Ron Lavy

  2. Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel

    Tima Davidson

  3. The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Ari Leshno

  4. Institute of Pathology, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel

    Judith Sandbank

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  1. Bar Chikman
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Correspondence to Ariel Halevy.

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The authors declare that have no conflict of interest. There are no sources of support for the work in the form of grants, equipment, drugs, or any combination of these. This retrospective study was conducted with the authorization of our Institutional Review Board.

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Chikman, B., Davidson, T., Kais, H. et al. Is there an association between invasive lobular carcinoma of the breast and a family history of gastric cancer?. Familial Cancer 15, 41–47 (2016). https://doi.org/10.1007/s10689-015-9833-9

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