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Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma’anshan birth cohort study

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Abstract

The aim of this study was to explore the impact of prenatal Al and Mg on placental oxidative stress and inflammatory mRNA expression. A total of 2519 pregnant women from the China Ma’anshan birth cohort participated in this study. Al and Mg levels were measured by inductively coupled plasma mass spectrometry (ICP-MS). Placental stress and inflammatory mRNA expression were assessed by RT-PCR. The median Al levels in the first and second trimesters of pregnancy and in cord blood were higher than the corresponding median Mg levels. Predictors of lower Al and Mg levels included Han ethnicity and high education according to a mixed linear model. Multiple linear regression analysis revealed that Al and Al/Mg levels had a positive association with inflammatory mRNA expression and placental oxidative stress in the second trimester of pregnancy. A negative association existed between Al and Al/Mg levels and inflammatory mRNA expression and placenta oxidative stress in the cord blood, with the exception of IL-1β expression. In conclusion, prenatal Al and Mg status was associated with placental oxidative stress and inflammatory mRNA expression. More preclinical studies are needed to confirm the relevant mechanism.

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Funding

This research was funded by National Natural Science Foundation of China (81330068, 81872630), China Postdoctoral Science Foundation funded project (2016M592041), and Postdoctoral Science Foundation funded project of Anhui Province (2016B114).

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Authors and Affiliations

  1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China

    Jian-Qing Wang, Ya-Bin Hu, Chun-Mei Liang, Xun Xia, Zhi-Juan Li, Hui Gao, Jie Sheng, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao & Fang-Biao Tao

  2. MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Jian-Qing Wang, Ya-Bin Hu, Chun-Mei Liang, Xun Xia, Zhi-Juan Li, Hui Gao, Jie Sheng, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao & Fang-Biao Tao

  3. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Jian-Qing Wang, Ya-Bin Hu, Chun-Mei Liang, Xun Xia, Zhi-Juan Li, Hui Gao, Jie Sheng, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao & Fang-Biao Tao

  4. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Jian-Qing Wang, Ya-Bin Hu, Chun-Mei Liang, Xun Xia, Zhi-Juan Li, Hui Gao, Jie Sheng, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao & Fang-Biao Tao

  5. The Fourth Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China

    Jian-Qing Wang & Yan Li

  6. Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China

    Xun Xia & Hui Gao

Authors
  1. Jian-Qing Wang
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  2. Ya-Bin Hu
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  3. Chun-Mei Liang
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  4. Xun Xia
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  5. Zhi-Juan Li
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  6. Hui Gao
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  7. Jie Sheng
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  8. Kun Huang
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  9. Su-Fang Wang
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  10. Yan Li
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  11. Peng Zhu
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  12. Jia-Hu Hao
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  13. Fang-Biao Tao
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Contributions

Conceptualization was contributed by J-QW and F-BT; methodology was contributed by C-ML; software was contributed by X-X; formal analysis was contributed by Y-BH, HG and YL; investigation was contributed by JS, KH, X-XC, L-JZ, Z-JL and S-FW; resources was contributed by X-X; data curation was contributed by L-JZ; writing—original draft preparation was contributed by J-QW; writing—review and editing was contributed by C-ML, PZ, J-HH; project administration was contributed by J-QW and C-ML; funding acquisition was contributed by J-QW and F-BT.

Corresponding author

Correspondence to Fang-Biao Tao.

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Wang, JQ., Hu, YB., Liang, CM. et al. Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma’anshan birth cohort study. Environ Geochem Health 42, 3887–3898 (2020). https://doi.org/10.1007/s10653-020-00619-x

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  • DOI: https://doi.org/10.1007/s10653-020-00619-x

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