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Long-term PERG monitoring of untreated and treated glaucoma suspects

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Abstract

Purpose

To investigate long-term structural and functional progression of untreated and treated glaucoma suspects (UGS and TGS).

Methods

Retrospective analysis of serial steady-state pattern electroretinogram (PERG), mean retinal nerve fiber layer thickness (RNFLT), and standard automated perimetry mean deviation (SAP-MD) in UGS (N = 20) and TGS (N = 18). Outcome measures were the rates of change (linear regression slopes) of PERG amplitude, PERG phase, mean RNFLT, and SAP-MD over 9.8 ± 1.3 years (15.6 ± 4.2 visits).

Results

The number of patients with significant (P < 0.05) progression slopes for PERG amplitude, PERG phase, RNFLT, and SAP-MD was, respectively, UGS: 5, 0, 4, 2; TGS: 8, 2, 6, 5. In UGS, outcome measures were not correlated with each other. In TGS, both PERG amplitude and RNFLT were significantly (P < 0.05) correlated with SAP-MD (R ≥ 0.58), while PERG amplitude and RNFLT were not correlated with each other (R = 0.43, P = 0.064). The rate of change of SAP-MD was predicted (P < 0.05) by a linear combination of RNFLT slope and PERG amplitude slope.

Conclusions

Results substantiate and extend previous results showing that steady-state PERG amplitude progressively decreased over time in a proportion of glaucoma suspects, with relatively steeper slope in TGS compared to UGS. RNFLT progression also had a steeper slope in TGS compared to UGS; however, progressions of PERG amplitude and RNFLT were not significantly correlated. Both PERG progression and RNFLT progression independently contribute to prediction of visual field progression.

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Acknowledgements

This work was supported by NIH-NEI RO1 EY014957, NIH center Grant P30-EY014801, and by unrestricted Grant to Bascom Palmer Eye Institute from Research to Prevent Blindness, Inc.

Funding

This study was funded by NIH-NEI RO1 EY014957, NIH center Grant P30-EY014801, and unrestricted grant to Bascom Palmer Eye Institute from Research to Prevent Blindness, Inc.

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Authors and Affiliations

  1. Mc Knight Vision Research Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave., Room 101, Miami, FL, 33136, USA

    Phillip S. Gordon, Maja Kostic, Pedro F. Monsalve, Giacinto Triolo, Luri Golubev, Gabriel Luna, Lori M. Ventura, William J. Feuer & Vittorio Porciatti

Authors
  1. Phillip S. Gordon
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  2. Maja Kostic
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  3. Pedro F. Monsalve
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  4. Giacinto Triolo
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  5. Luri Golubev
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  6. Gabriel Luna
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  7. Lori M. Ventura
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  8. William J. Feuer
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  9. Vittorio Porciatti
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Corresponding author

Correspondence to Vittorio Porciatti.

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The authors declare that there is no conflict of interest regarding the publication of this article. The authors alone are responsible for the content and writing of the paper.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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All individuals involved in the study were informed of the purpose of the study, and their informed consent was obtained. This study followed the tenets of the Declaration of Helsinki and was approved by the ethics committee of the institutional First Affiliated Hospital of Chongqing Medical University.

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Gordon, P.S., Kostic, M., Monsalve, P.F. et al. Long-term PERG monitoring of untreated and treated glaucoma suspects. Doc Ophthalmol 141, 149–156 (2020). https://doi.org/10.1007/s10633-020-09760-5

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  • DOI: https://doi.org/10.1007/s10633-020-09760-5

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