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Colitis and Pancreatitis in a Patient with Systemic Lupus Erythematosus: Due to Disease or to Drug?

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References

  1. Taylor DO, Ensley RD, Olsen SL, Dunn D, et al. Mycophenolate mofetil (RS-61443): preclinical, clinical, and three-year experience in heart transplantation. J Heart Lung Transplant. 1994;13:571–582.

    PubMed  CAS  Google Scholar 

  2. Gorospe EC. Chronic diarrhoea from mycophenolate mofetil-induced colitis. BMJ Case Rep. 2012;2012:bcr1220115344. https://doi.org/10.1136/bcr.122011.5344.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Goyal A, Salahuddin M, Govil Y. A unique case of mycophenolate induced colitis after 10 years of use. Case Rep Gastrointest Med. 2016;2016:3058407. https://doi.org/10.1155/2916/3058407.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Moroncini G, Benfaremo D, Mandolesi A, Gabrielli A. Mycophenolate mofetil-induced colitis in a patient with systemic sclerosis. BMJ Case Rep. 2018. https://doi.org/10.1136/bcr-2018-224829.

    Article  PubMed  Google Scholar 

  5. Dall’Era M. Mycophenolate mofetil in the treatment of systemic lupus erythematosus. Curr Opin Rheumatol. 2011;23:454–458.

    Article  PubMed  CAS  Google Scholar 

  6. Villarroel MC, Hidalgo M, Jimeno A. Mycophenolate mofetil: an update. Drugs Today. 2009;45:521–532.

    PubMed  CAS  Google Scholar 

  7. Moore RA, Derry S. Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis. Arthritis Res Ther. 2006;8:R182.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Allison AC, Eugui EM. Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection. Transplantation. 2005;80:S181–S190.

    Article  PubMed  CAS  Google Scholar 

  9. Wieland E, Shipkova M, Schellhaas U, Schutz E, et al. Induction of cytokine release by the acyl glucuronide of mycophenolic acid: a link to side effects? Clin Biochem. 2000;33:107–113.

    Article  PubMed  CAS  Google Scholar 

  10. Khoury N, Ammor M, Durrbach A, Kriaa F, et al. Diffuse colitis associated with mycophenolate mofetil treatment: apropos of 1 case. Nephrologie. 2000;21:437–439.

    PubMed  CAS  Google Scholar 

  11. Endo H, Kondo Y, Kawagoe K, Ohya TR, et al. Lupus enteritis detected by capsule endoscopy. Intern Med. 2007;46:1621–1622.

    Article  PubMed  Google Scholar 

  12. Lee CK, Ahn MS, Lee EY, Shin JH, et al. Acute abdominal pain in systemic lupus erythematosus: focus on lupus enteritis (gastrointestinal vasculitis). Ann Rheum Dis. 2002;61:547–550.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Lian TY, Edwards CJ, Chan SP, Chng HH. Reversible acute gastrointestinal syndrome associated with active systemic lupus erythematosus in patients admitted to hospital. Lupus. 2003;12:612–616.

    Article  PubMed  CAS  Google Scholar 

  14. Kwok SK, Seo SH, Ju JH, Park KS, et al. Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody. Lupus. 2007;16:803–809.

    Article  PubMed  CAS  Google Scholar 

  15. Cervera R, Espinosa G, Cordero A, Oltra MR, et al. Intestinal involvement secondary to the antiphospholipid syndrome (APS): clinical and immunologic characteristics of 97 patients: comparison of classic and catastrophic APS. Semin Arthritis Rheum. 2007;36:287–296.

    Article  PubMed  CAS  Google Scholar 

  16. Helliwell TR, Flook D, Whitworth J, Day DW. Arteritis and venulitis in systemic lupus erythematosus resulting in massive lower intestinal haemorrhage. Histopathology. 1985;9:1103–1113.

    Article  PubMed  CAS  Google Scholar 

  17. Calmet FH, Yarur AJ, Pukazhendhi G, Ahmad J. Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation. Ann Gastroenterol. 2015;28:366–373.

    PubMed  PubMed Central  Google Scholar 

  18. de Andrade LG, Rodrigues MA, Romeiro FG, Garcia PD, et al. Clinicopathologic features and outcome of mycophenolate-induced colitis in renal transplant recipients. Clin Transplant. 2014;28:1244–1248.

    Article  PubMed  CAS  Google Scholar 

  19. Selbst MK, Ahrens WA, Robert ME, Friedman A, et al. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol. 2009;22:737–743.

    Article  PubMed  CAS  Google Scholar 

  20. Liapis G, Boletis J, Skalioti C, Bamias G, et al. Histological spectrum of mycophenolate mofetil-related colitis: association with apoptosis. Histopathology. 2013;63:649–658.

    PubMed  Google Scholar 

  21. Bjarnason I. Enteric coating of mycophenolate sodium: a rational approach to limit topical gastrointestinal lesions and extend the therapeutic index of mycophenolate. Transpl Proc. 2001;33:3238–3240.

    Article  CAS  Google Scholar 

  22. Pescovitz MD, Conti D, Dunn J, Gonwa T, et al. Intravenous mycophenolate mofetil: safety, tolerability, and pharmacokinetics. Clin Transplant. 2000;14:179–188.

    Article  PubMed  CAS  Google Scholar 

  23. Perrin L, Giurgea I, Baudet-Bonneville V, Deschênes G, et al. Acute pancreatitis in paediatric systemic lupus erythematosus. Acta Paediatr. 2006;95:121–124.

    Article  PubMed  Google Scholar 

  24. Nesher G, Breuer GS, Temprano K, Moore TL, et al. Lupus-associated pancreatitis. Semin Arthritis Rheum. 2006;35:260–267. (review).

    Article  PubMed  Google Scholar 

  25. Cairoli E, Pérez G, Briva A, Cancela M, Alonso J. Fatal acute pancreatitis complicated by pancreatic pseudocysts in a patient with systemic lupus erythematosus. Rheumatol Int. 2010;30:675–678. https://doi.org/10.1007/s00296-009-0964-x. (Epub 2009 May 23).

    Article  PubMed  Google Scholar 

  26. Dooley MA, Cosio FG, Nachman PH, Falkenhain ME, et al. Mycophenolate mofetil therapy in lupus nephritis: clinical observations. J Am Soc Nephrol. 1999;10:833–839.

    PubMed  CAS  Google Scholar 

  27. Einollahi B, Dolatimehr F. Acute pancreatitis induced by mycophenolate mofetil in a kidney transplant patient. J Nephropharmacol. 2015;4:72–74.

    PubMed  PubMed Central  Google Scholar 

  28. Sodikoff JB, Keilin SA, Cai Q, Bharmal SJ, et al. Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis. World J Gastroenterol. 2012;18:2287–2290. https://doi.org/10.3748/wjg.v18.i18.2287.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico School of Medicine, MSC10-5550, Albuquerque, NM, 87131, USA

    Swathi Paleti, Anas Gremida & Denis McCarthy

  2. Department of Internal Medicine, University of Kansas School of Medicine, Kansas City, KS, USA

    Bharath Yarlagadda & Muhammad Aziz

  3. Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Joshua Hanson

Authors
  1. Swathi Paleti
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  2. Bharath Yarlagadda
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  3. Anas Gremida
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  4. Muhammad Aziz
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  5. Joshua Hanson
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  6. Denis McCarthy
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Correspondence to Swathi Paleti.

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Paleti, S., Yarlagadda, B., Gremida, A. et al. Colitis and Pancreatitis in a Patient with Systemic Lupus Erythematosus: Due to Disease or to Drug?. Dig Dis Sci 63, 2206–2209 (2018). https://doi.org/10.1007/s10620-018-5225-y

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