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Two New Anti-Tobacco Mosaic Virus Alkaloids from the Whole Plants of Thalictrum microgynum

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Chemistry of Natural Compounds Aims and scope

Two new (1 and 2), together with four known (3–6) alkaloids were isolated from the whole plants of Thalictrum microgynum. Compounds 1–6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results indicated that compounds 2–4 showed high anti-TMV activity with inhibition rates of 34.8, 42.1, and 35.2% at a concentration of 20 μM, respectively. These rates were higher than that of ningnanmycin, a positive control. Compounds 1, 5, and 6 also showed potential anti-TMV activity with inhibition rates of 26.7, 24.8, and 28.2%.

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Acknowledgment

This project was supported by the Foundation of Yunnan Tobacco Company (2021530000241003 and 2020530000241001), the National Natural Science Foundation of China (No. 21762050), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (grant to M.Z.), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Yunnan Academy of Tobacco Agricultural Sciences, Kunming, 650031, Yunnan, P. R. China

    Yu-Ping Wu, Zhong-Long Lin, Gao-Kun Zhao, Heng Yao, Guang-Hai Zhang, Wei Li & Guang-Hui Kong

  2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Yu-Ping Wu, Min Zhou, Guang-Yu Yang, Yin-Ke Li & Qiu-Fen Hu

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  1. Yu-Ping Wu
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  2. Zhong-Long Lin
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  3. Gao-Kun Zhao
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  4. Min Zhou
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  5. Heng Yao
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  6. Guang-Hai Zhang
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  7. Wei Li
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  10. Qiu-Fen Hu
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Corresponding authors

Correspondence to Qiu-Fen Hu or Guang-Hui Kong.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 593–596.

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Wu, YP., Lin, ZL., Zhao, GK. et al. Two New Anti-Tobacco Mosaic Virus Alkaloids from the Whole Plants of Thalictrum microgynum. Chem Nat Compd 58, 699–703 (2022). https://doi.org/10.1007/s10600-022-03771-1

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  • DOI: https://doi.org/10.1007/s10600-022-03771-1

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