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Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity

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Chemistry of Natural Compounds Aims and scope

Two new coumarins, 6-hydroxymethyl-3-prenyl-7-methoxycoumarin (1) and 6-hydroxyethyl-3-prenyl-7- methoxycoumarin (2), together with three known coumarins (3–5), were isolated from the roots and stems of Yunyan-300, a variety of Nicotiana tabacum L. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillinresistant Staphylococcus aureus (anti-MRSA) activity and their antioxidant activity. The results revealed that compounds 1 and 2 showed good anti-MRSA inhibitions with IZD of 12.2 ± 1.8 and 11.8 ± 1.5 mm, respectively, and antioxidant activity with an IC50 value of 4.65 and 4.85 μg/mL, respectively.

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Acknowledgment

This project was supported financially by the Foundation of Yunnan Tobacco Industry Co. Ltd. (2019JC04 and 2018JC07), the Foundation of China Tobacco Company (No. 110201901016), the high-tech projects of Yunnan Province (2017ZE027), and the National Natural Science Foundation of China (No. 31860100).

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Li-Jun Zhu, Dian Luo, Na Lv, Qian Gao, Gan-Peng Li, Guang-Yu Yang, Ying Guan & Yan-Qing Ye

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Li-Jun Zhu, Dian Luo, Yin-ke Li, Qi-Li Mi, Jin Wang, Wei-Song Kong, Guang-Yu Yang, Qiu-Fen Hu, Ying Guan & Yan-Qing Ye

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  1. Li-Jun Zhu
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  2. Dian Luo
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  3. Na Lv
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  4. Yin-ke Li
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Correspondence to Ying Guan or Yan-Qing Ye.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2020, pp. 693–696.

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Zhu, LJ., Luo, D., Lv, N. et al. Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity. Chem Nat Compd 56, 806–810 (2020). https://doi.org/10.1007/s10600-020-03157-1

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  • DOI: https://doi.org/10.1007/s10600-020-03157-1

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