One new griseofulvin derivative, (+)-5-chlorogriseofulvin (1), together with two known analogues, griseofulvin (2) and dechlorogriseofulvin (3), was isolated from the marine-derived fungus Arthrinium sp. collected from the South China Sea. The structure of the new compound was elucidated on the basis of NMR spectroscopic data and on the basis of the CD experiments compared with those of 2 and 3. Compound 1 exhibited moderate lethality against the brine shrimp Artemia salina with an LC50 value of 25 μg/mL. All the compounds showed weak antibacterial activity against Dysentery bacillus and Micrococcus luteus with an MIC value of 100 μM.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. W. Blunt, B. R. Copp, R. A. Keyzers, M. H. G. Munro, and M. R. Prinsep, Nat. Prod. Rep., 32, 116 (2015).
K. L. Yang, M. Y. Wei, C. L. Shao, X. M. Fu, Z. Y. Guo, R. F. Xu, C. J. Zheng, Z. G. She, Y. C. Lin, and C. Y. Wang, J. Nat. Prod., 75, 935 (2012).
X. Y. Qin, K. L. Yang, C. Y. Wang, and C. L. Shao, Chem. Nat. Compd., 50, 571 (2014).
M. Y. Wei, G. Y. Chen, Y. Wang, X. L. Zhang, C. Y. Wang, and C. L. Shao, Chem. Nat. Compd., 47, 571 (2011).
M. Y. Wei, R. Y. Yang, C. L. Shao, C. Y. Wang, D. S. Deng, Z. G. She, and Y. C. Lin, Chem. Nat. Compd., 47, 322 (2011).
C. L. Shao, H. X. Wu, C. Y. Wang, Q. A. Liu, Y. Xu, M. Y. Wei, P. Y. Qian, Y. C. Gu, C. J. Zheng, Z. G. She, and Y. C. Lin, J. Nat. Prod., 74, 629 (2011).
M. Y. Wei, D. Li, C. L. Shao, D. S. Deng, and C. Y. Wang, Mar. Drugs, 11, 1050 (2013).
Y. Takeuchi, I. Watanabe, K. Misumi, M. Irie, Y. Hirose, K. Hirata, M. Yamato, and T. Harayama, Chem. Pharm. Bull., 45, 2011 (1997).
J. -H. Park, G. J. Choi, H. B. Lee, K. M. Kim, H. S. Jung, S.-W. Lee, K. S. Jang, K. Y. Cho, and J.-C. Kim, J. Microbiol. Biotechnol, 15, 112 (2005).
P. N. Solis, C. W. Wright, M. M. Anderson, M. P. Gupta, and J. D. Phillipson, Planta Med., 59, 250 (1993).
R. A. Fromtling, J. N. Galgiani, M. A. Pfaller, A. Espinel-Ingroff, K. F. Bartizal, M. S. Bartlett, B. A. Body, C. Frey, G. Hall, G. D. Roberts, F. B. Noltt, E. C. Odds, M. G. Rinaldi, A. M. Suger, and K. Villareal, Antimicrob. Agents Chemother., 37, 39 (1993).
Acknowledgment
We acknowledge funding from the Program of National Natural Science Foundation of China (Nos. 41176121; 41322037; 41130858).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2016, pp. 869–871.
Rights and permissions
About this article
Cite this article
Wei, MY., Xu, RF., Du, SY. et al. A New Griseofulvin Derivative from the Marine-Derived Arthrinium sp. Fungus and Its Biological Activity. Chem Nat Compd 52, 1011–1014 (2016). https://doi.org/10.1007/s10600-016-1849-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-016-1849-3