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Synthesis, Transformations, and Physicochemical Properties of 3-(4′-Methylphenyl)-8-Methylxanthine Derivatives

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Chemistry of Natural Compounds Aims and scope

A preparative method for producing of 3-(4′-methylphenyl)-8-methylxanthine, its 7-substituted derivatives, 3-(4′-methylphenyl)-8-methylxanthinyl-7-acetic acid, its ester, amide, hydrazide, ylidenehydrazides, and N-phenylhydrazinocarbothiamide was developed. The structure of the cyclization product of the last, 3-(4′-methylphenyl)-7-[2-(4″-phenyl-5″-thio-4″H-[1″,2″,4″]triazol-3″-yl)methyl]xanthine, was confirmed by elemental analysis and PMR spectroscopy.

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Authors and Affiliations

  1. Zaporozhe State Medical University, 69035, Ukraine, Zaporozhe, Prosp. Mayakovskogo, 26

    E. V. Aleksandrova, S. V. Levich, N. I. Romanenko, A. S. Shkoda & E. K. Mikhal′chenko

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  1. E. V. Aleksandrova
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  2. S. V. Levich
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  3. N. I. Romanenko
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  4. A. S. Shkoda
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  5. E. K. Mikhal′chenko
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Correspondence to E. V. Aleksandrova.

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Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2013, pp. 950–953.

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Aleksandrova, E.V., Levich, S.V., Romanenko, N.I. et al. Synthesis, Transformations, and Physicochemical Properties of 3-(4′-Methylphenyl)-8-Methylxanthine Derivatives. Chem Nat Compd 49, 1105–1109 (2014). https://doi.org/10.1007/s10600-014-0830-2

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  • DOI: https://doi.org/10.1007/s10600-014-0830-2

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