Skip to main content
SpringerLink
Log in

First spin-labeled cytisine derivatives

  • Published:
Chemistry of Natural Compounds Aims and scope

Spin-labeled cytisine derivatives containing stable pyrrolidine and piperidine nitroxyl radicals were synthesized by acylation and alkylation of the secondary amine. Toxicological studies showed that introduction of the nitroxyl group decreased significantly the general toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Z. D. Raikov, E. T. Raikova, and A. T. Atanasov, Med. Hypotheses, 57, 302 (2001); J. Russel, N. Okayama, J. S. Alexander, D. N. Granger, and C. J. Hsia, Free Radical Biol. Med., 25, 153 (1998); P. Seminara, F. Franchi, N. Konovalova, C. Pioli, R. Rossetti, L. Tubani, G. Doria, and F. R. Fanelli, Acta Haematol., 105, 77 (2001); J. Skolimowski, A. Kochman, L. Cebicka, and D. Metodiewa, Bioorg. Med. Chem., 11, 3529 (2003).

  2. P. Tutka and W. Zatonski, Pharmacol. Rep., 58, 777 (2006).

    PubMed  CAS  Google Scholar 

  3. A. P. Kozikowski, S. K. Chellappan, Y. Xiao, K. M. Bajjuri, H. Yuan, K. J. Kellar, and P. A. Petukhov, Chem. Med. Chem., 2, 1157 (2007).

    PubMed  CAS  Google Scholar 

  4. E. G. Perez, C. Mendez-Galvez, and B. K. Cassels, Nat. Prod. Rep., 29, 555 (2012).

    Article  PubMed  CAS  Google Scholar 

  5. M. S. Frasinyuk, V. I. Vinogradova, S. P. Bondarenko, and V. P. Khilya, Chem. Nat. Compd., 43, 590 (2007).

    Article  CAS  Google Scholar 

  6. S. P. Bondarenko, M. S. Frasinyuk, V. I. Vinogradova, and V. P. Khilya, Chem. Nat. Compd., 46, 771 (2010).

    Article  CAS  Google Scholar 

  7. S. P. Bondarenko, M. S. Frasinyuk, V. I. Vinogradova, and V. P. Khilya, Chem. Nat. Compd., 47, 604 (2011).

    Article  CAS  Google Scholar 

  8. V. A. Saprykina, V. I. Vinogradova, R. F. Ambartsumova, T. F. Ibragimov, and Kh. M. Sakhidoyatov, Chem. Nat. Compd., 42, 470 (2006).

    Article  CAS  Google Scholar 

  9. A. K. Przybyl and M. Kubicki, J. Mol. Struct., 985, 157 (2011).

    Article  CAS  Google Scholar 

  10. I. V. Kulakov, D. M. Turdybekov, Z. M. Zhambekov, O. A. Nurkenov, B. T. Ibragimov, S. A. Talipov, and K. M. Turdybekov, Khim. Prir. Soedin., 572 (2009).

  11. L. B. Volodarskii, I. A. Grigorev, S. A. Dikanov, V. A. Reznikov, and G. I. Shchukin, Imidazoline Nitroxyl Radicals [in Russian], Nauka, Novosibirsk, Sib. Br., 1988, 216 pp.

  12. M. Niks and M. Otto, J. Immunol. Methods, 130, 149 (1990).

    Article  PubMed  CAS  Google Scholar 

  13. L. Berliner (ed.), Spin Labeling/ 1., Academic Press, New York, 1976.

    Google Scholar 

  14. S. Ogawa and H. M. McConnel, Proc. Natl. Acad. Sci. USA, 58, 19 (1967).

    Article  PubMed  CAS  Google Scholar 

  15. H. O. Hankovszky, K. Hideg, and J. Tigyi, Acta Chim. Acad. Sci. Hung., 98, 339 (1978).

    CAS  Google Scholar 

Download references

Acknowledgment

The work was supported financially by RFBR Grant No. 12-03-00718a and the Moscow Administration Program (Contract No. 16-12-Gen-M). Spectral characteristics and XSA data of the synthesized compounds were obtained at the Chemical Service, CCH, SB, RAS.

Author information

Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Prosp. Akad. Lavrent’eva, 9, Russia

    Yu. F. Polienko, Yu. V. Gatilov & I. A. Grigor′ev

  2. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, Uzbekistan

    V. I. Vinogradova, Sh. Sh. Sagdullaev & N. D. Abdullaev

Authors
  1. Yu. F. Polienko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. I. Vinogradova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sh. Sh. Sagdullaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. D. Abdullaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. V. Gatilov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. A. Grigor′ev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. F. Polienko.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2013, pp. 264–267.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Polienko, Y.F., Vinogradova, V.I., Sagdullaev, S.S. et al. First spin-labeled cytisine derivatives. Chem Nat Compd 49, 311–315 (2013). https://doi.org/10.1007/s10600-013-0588-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-013-0588-y

Keywords

Search

Navigation