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Environmentally benign one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives applying montmorillonite K10 as reusable catalyst

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Chemistry of Heterocyclic Compounds Aims and scope

Environmentally benign one-pot multicomponent synthesis of different 1,4-dihydropyridine derivatives using montmorillonite K10 has been achieved. The montmorillonite K10-catalyzed reaction of aromatic aldehyde, malononitrile, substituted aniline, and diethyl acetylenedicarboxylate in H2O–EtOH allows to obtain structurally diverse 1,4-dihydropyridines in high yields. Possibility to recover and reuse the acidic catalyst in up to five catalytic cycles has been demonstrated. Short reaction times, suppressed formation of side products, inexpensive and nontoxic solvent system, catalyst recovery, and simple workup procedure are the main advantages of the developed synthetic method.

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The author Guda Mallikarjuna Reddy is grateful to Brazilian Higher Education Personnel Training Coordination (CAPES: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) for the fellowship under the PNPD program.

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Authors and Affiliations

  1. Natural Product Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Telangana, 500007, India

    Vemulapati Hanuman Reddy & Avula Krishna Kumari

  2. Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, 517502, India

    Vemulapati Hanuman Reddy & Yellala Venkata Rami Reddy

  3. Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg, 620002, Russia

    Guda Mallikarjuna Reddy, Grigory V. Zyryanov, Nemallapudi Bakthavatchala Reddy & Aluru Rammohan

  4. Department of Chemistry, State University of Ponta Grossa, General Carlos Cavalcanti Ave., Ponta Grossa, Paraná, 4748 – CEP 84030-900, Brazil

    Guda Mallikarjuna Reddy & Jarem Raul Garcia

  5. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg, 620219, Russia

    Grigory V. Zyryanov

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  1. Vemulapati Hanuman Reddy
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  2. Avula Krishna Kumari
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  3. Guda Mallikarjuna Reddy
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  4. Yellala Venkata Rami Reddy
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  7. Nemallapudi Bakthavatchala Reddy
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Correspondence to Vemulapati Hanuman Reddy or Jarem Raul Garcia.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(1), 60–65

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Reddy, V.H., Kumari, A.K., Reddy, G.M. et al. Environmentally benign one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives applying montmorillonite K10 as reusable catalyst. Chem Heterocycl Comp 55, 60–65 (2019). https://doi.org/10.1007/s10593-019-02419-3

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